FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105403778> ?p ?o ?g. }

• W2105403778 endingPage "1820" @default.
• W2105403778 startingPage "1813" @default.
• W2105403778 abstract "No vaccine is currently available for visceral leishmaniasis (VL) caused by Leishmania donovani. This study addresses whether a live attenuated centrin gene-deleted L. donovani (LdCen1(-/-)) parasite can persist and be both safe and protective in animals. LdCen1(-/-) has a defect in amastigote replication both in vitro and ex vivo in human macrophages. Safety was shown by the lack of parasites in spleen and liver in susceptible BALB/c mice, immune compromised SCID mice, and human VL model hamsters 10 wk after infection. Mice immunized with LdCen1(-/-) showed early clearance of virulent parasite challenge not seen in mice immunized with heat killed parasites. Upon virulent challenge, the immunized mice displayed in the CD4(+) T cell population a significant increase of single and multiple cytokine (IFN-gamma, IL-2, and TNF) producing cells and IFN-gamma/IL10 ratio. Immunized mice also showed increased IgG2a immunoglobulins and NO production in macrophages. These features indicated a protective Th1-type immune response. The Th1 response correlated with a significantly reduced parasite burden in the spleen and no parasites in the liver compared with naive mice 10 wk post challenge. Protection was observed, when challenged even after 16 wk post immunization, signifying a sustained immunity. Protection by immunization with attenuated parasites was also seen in hamsters. Immunization with LdCen1(-/-) also cross-protected mice against infection with L. braziliensis that causes mucocutaneous leishmaniasis. Results indicate that LdCen1(-/-) can be a safe and effective vaccine candidate against VL as well as mucocutaneous leishmaniasis causing parasites." @default.
• W2105403778 created "2016-06-24" @default.
• W2105403778 creator A5000479943 @default.
• W2105403778 creator A5029794318 @default.
• W2105403778 creator A5034801475 @default.
• W2105403778 creator A5060893561 @default.
• W2105403778 creator A5075629727 @default.
• W2105403778 creator A5084452838 @default.
• W2105403778 date "2009-08-01" @default.
• W2105403778 modified "2023-09-30" @default.
• W2105403778 title "Intracellular Replication-Deficient <i>Leishmania donovani</i> Induces Long Lasting Protective Immunity against Visceral Leishmaniasis" @default.
• W2105403778 cites W1605898561 @default.
• W2105403778 cites W1607721371 @default.
• W2105403778 cites W1788285188 @default.
• W2105403778 cites W1851218522 @default.
• W2105403778 cites W1874018940 @default.
• W2105403778 cites W1968292510 @default.
• W2105403778 cites W1968708450 @default.
• W2105403778 cites W1974781378 @default.
• W2105403778 cites W1989935348 @default.
• W2105403778 cites W2018623169 @default.
• W2105403778 cites W2026286437 @default.
• W2105403778 cites W2028929360 @default.
• W2105403778 cites W2058767682 @default.
• W2105403778 cites W2060098125 @default.
• W2105403778 cites W2063680573 @default.
• W2105403778 cites W2063680727 @default.
• W2105403778 cites W2066738380 @default.
• W2105403778 cites W2067648924 @default.
• W2105403778 cites W2073179858 @default.
• W2105403778 cites W2074216759 @default.
• W2105403778 cites W2087111540 @default.
• W2105403778 cites W2099973325 @default.
• W2105403778 cites W2108658278 @default.
• W2105403778 cites W2109098886 @default.
• W2105403778 cites W2111621095 @default.
• W2105403778 cites W2112560211 @default.
• W2105403778 cites W2113632542 @default.
• W2105403778 cites W2123874690 @default.
• W2105403778 cites W2131431262 @default.
• W2105403778 cites W2132956923 @default.
• W2105403778 cites W2139412010 @default.
• W2105403778 cites W2139914457 @default.
• W2105403778 cites W2140056038 @default.
• W2105403778 cites W2147898139 @default.
• W2105403778 cites W2151440062 @default.
• W2105403778 cites W2151737163 @default.
• W2105403778 cites W2156862710 @default.
• W2105403778 cites W2158496239 @default.
• W2105403778 cites W2160927866 @default.
• W2105403778 cites W2164272292 @default.
• W2105403778 cites W2168797800 @default.
• W2105403778 doi "https://doi.org/10.4049/jimmunol.0900276" @default.
• W2105403778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19592661" @default.
• W2105403778 hasPublicationYear "2009" @default.
• W2105403778 type Work @default.
• W2105403778 sameAs 2105403778 @default.
• W2105403778 citedByCount "148" @default.
• W2105403778 countsByYear W21054037782012 @default.
• W2105403778 countsByYear W21054037782013 @default.
• W2105403778 countsByYear W21054037782014 @default.
• W2105403778 countsByYear W21054037782015 @default.
• W2105403778 countsByYear W21054037782016 @default.
• W2105403778 countsByYear W21054037782017 @default.
• W2105403778 countsByYear W21054037782018 @default.
• W2105403778 countsByYear W21054037782019 @default.
• W2105403778 countsByYear W21054037782020 @default.
• W2105403778 countsByYear W21054037782021 @default.
• W2105403778 countsByYear W21054037782022 @default.
• W2105403778 countsByYear W21054037782023 @default.
• W2105403778 crossrefType "journal-article" @default.
• W2105403778 hasAuthorship W2105403778A5000479943 @default.
• W2105403778 hasAuthorship W2105403778A5029794318 @default.
• W2105403778 hasAuthorship W2105403778A5034801475 @default.
• W2105403778 hasAuthorship W2105403778A5060893561 @default.
• W2105403778 hasAuthorship W2105403778A5075629727 @default.
• W2105403778 hasAuthorship W2105403778A5084452838 @default.
• W2105403778 hasBestOaLocation W21054037781 @default.
• W2105403778 hasConcept C136764020 @default.
• W2105403778 hasConcept C159047783 @default.
• W2105403778 hasConcept C203014093 @default.
• W2105403778 hasConcept C2776555147 @default.
• W2105403778 hasConcept C2778689377 @default.
• W2105403778 hasConcept C2779341262 @default.
• W2105403778 hasConcept C2780801004 @default.
• W2105403778 hasConcept C2780931953 @default.
• W2105403778 hasConcept C2781092759 @default.
• W2105403778 hasConcept C2781333301 @default.
• W2105403778 hasConcept C2908647359 @default.
• W2105403778 hasConcept C41008148 @default.
• W2105403778 hasConcept C71924100 @default.
• W2105403778 hasConcept C71928629 @default.
• W2105403778 hasConcept C86803240 @default.
• W2105403778 hasConcept C8891405 @default.
• W2105403778 hasConcept C98319499 @default.
• W2105403778 hasConcept C99454951 @default.
• W2105403778 hasConceptScore W2105403778C136764020 @default.
• W2105403778 hasConceptScore W2105403778C159047783 @default.

• next