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• W2105404306 abstract "Estrogens affect a diversity of peripheral and central physiological endpoints. Traditionally, estrogens were thought to be peripherally derived transcription regulators (i.e. slow acting). More recently, we have learned that estrogens are also synthesized in neuronal cell bodies and synaptic terminals and have potent membrane effects, which modulate brain function. However, the mechanisms that control local steroid concentrations in a temporal and spatial resolution compatible with their acute actions are poorly understood. Here, using differential centrifugation followed by enzymatic assay, we provide evidence that estrogen synthesis within synaptosomes can be modulated more dramatically by phosphorylating conditions, relative to microsomes. This is the first demonstration of a rapid mechanism that may alter steroid concentrations within the synapse and may represent a potential mechanism for the acute control of neurophysiology and behavior." @default.
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• W2105404306 date "2012-06-01" @default.
• W2105404306 modified "2023-10-18" @default.
• W2105404306 title "Acute and Specific Modulation of Presynaptic Aromatization in the Vertebrate Brain" @default.
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• W2105404306 doi "https://doi.org/10.1210/en.2011-2159" @default.
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