FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105416140> ?p ?o ?g. }

• W2105416140 endingPage "556" @default.
• W2105416140 startingPage "549" @default.
• W2105416140 abstract "The neurodegenerative disorder Andermann syndrome is caused by mutations of the K-Cl cotransporter KCC3. Mice with a targeted disruption of the corresponding gene, Slc12a6 , reproduce neurodegeneration of the peripheral and central nervous system (CNS) and display arterial hypertension. Kcc3 is expressed in numerous tissues, including the CNS and vascular smooth muscle cells. As the intracellular chloride concentration may influence myogenic tone and hence blood pressure, we measured the chloride concentration in vascular smooth muscle cells. It was indeed increased in superficial brain arteries and saphenous arteries of Kcc3 −/− mice. Isolated saphenous arteries and their third-order branches, however, reacted indistinguishably to changes in intravascular pressure, stimulation of α 1 -adrenoreceptors, exogenous nitric oxide, or blockade of calcium-activated chloride channels. Likewise, the responses to α 1 -adrenergic stimulation or exogenous nitric oxide in vivo were identical in both genotypes. These results argue against a major vascular-intrinsic component of arterial hypertension in Kcc3 −/− mice. In contrast, either α 1 -adrenergic blockade or inhibition of ganglionic transmission abolished the difference in arterial blood pressure between both genotypes. This demonstrates a neurogenic component in the maintenance of this phenotype, which is further supported by an increase of urinary norepinephrine and epinephrine excretion in Kcc3 −/− mice. Our data indicate that local control of myogenic tone does not require KCC3 and that hypertension in Kcc3 −/− mice depends on an elevated sympathetic tone." @default.
• W2105416140 created "2016-06-24" @default.
• W2105416140 creator A5002685729 @default.
• W2105416140 creator A5004432141 @default.
• W2105416140 creator A5009733924 @default.
• W2105416140 creator A5016899192 @default.
• W2105416140 creator A5020175571 @default.
• W2105416140 creator A5026195595 @default.
• W2105416140 creator A5030332945 @default.
• W2105416140 creator A5050550373 @default.
• W2105416140 creator A5051373487 @default.
• W2105416140 creator A5057172409 @default.
• W2105416140 creator A5066164614 @default.
• W2105416140 creator A5068830578 @default.
• W2105416140 date "2006-03-03" @default.
• W2105416140 modified "2023-09-25" @default.
• W2105416140 title "Neurogenic Mechanisms Contribute to Hypertension in Mice With Disruption of the K-Cl Cotransporter KCC3" @default.
• W2105416140 cites W1588629441 @default.
• W2105416140 cites W1894088205 @default.
• W2105416140 cites W1905908978 @default.
• W2105416140 cites W1967180560 @default.
• W2105416140 cites W1967546787 @default.
• W2105416140 cites W2061595855 @default.
• W2105416140 cites W2061852731 @default.
• W2105416140 cites W2075976227 @default.
• W2105416140 cites W2079674540 @default.
• W2105416140 cites W2129176777 @default.
• W2105416140 cites W2129343903 @default.
• W2105416140 cites W2130493951 @default.
• W2105416140 cites W2133316521 @default.
• W2105416140 cites W2136405204 @default.
• W2105416140 cites W2137163623 @default.
• W2105416140 cites W2139722622 @default.
• W2105416140 cites W2145502354 @default.
• W2105416140 cites W2149132899 @default.
• W2105416140 cites W2151206192 @default.
• W2105416140 cites W2160342349 @default.
• W2105416140 cites W2275546552 @default.
• W2105416140 cites W2319124197 @default.
• W2105416140 cites W2320891205 @default.
• W2105416140 cites W2397568802 @default.
• W2105416140 cites W54549707 @default.
• W2105416140 doi "https://doi.org/10.1161/01.res.0000204449.83861.22" @default.
• W2105416140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16424367" @default.
• W2105416140 hasPublicationYear "2006" @default.
• W2105416140 type Work @default.
• W2105416140 sameAs 2105416140 @default.
• W2105416140 citedByCount "50" @default.
• W2105416140 countsByYear W21054161402012 @default.
• W2105416140 countsByYear W21054161402013 @default.
• W2105416140 countsByYear W21054161402014 @default.
• W2105416140 countsByYear W21054161402015 @default.
• W2105416140 countsByYear W21054161402016 @default.
• W2105416140 countsByYear W21054161402017 @default.
• W2105416140 countsByYear W21054161402018 @default.
• W2105416140 countsByYear W21054161402019 @default.
• W2105416140 countsByYear W21054161402020 @default.
• W2105416140 countsByYear W21054161402021 @default.
• W2105416140 countsByYear W21054161402022 @default.
• W2105416140 countsByYear W21054161402023 @default.
• W2105416140 crossrefType "journal-article" @default.
• W2105416140 hasAuthorship W2105416140A5002685729 @default.
• W2105416140 hasAuthorship W2105416140A5004432141 @default.
• W2105416140 hasAuthorship W2105416140A5009733924 @default.
• W2105416140 hasAuthorship W2105416140A5016899192 @default.
• W2105416140 hasAuthorship W2105416140A5020175571 @default.
• W2105416140 hasAuthorship W2105416140A5026195595 @default.
• W2105416140 hasAuthorship W2105416140A5030332945 @default.
• W2105416140 hasAuthorship W2105416140A5050550373 @default.
• W2105416140 hasAuthorship W2105416140A5051373487 @default.
• W2105416140 hasAuthorship W2105416140A5057172409 @default.
• W2105416140 hasAuthorship W2105416140A5066164614 @default.
• W2105416140 hasAuthorship W2105416140A5068830578 @default.
• W2105416140 hasBestOaLocation W21054161401 @default.
• W2105416140 hasConcept C126322002 @default.
• W2105416140 hasConcept C134018914 @default.
• W2105416140 hasConcept C178790620 @default.
• W2105416140 hasConcept C185592680 @default.
• W2105416140 hasConcept C188053792 @default.
• W2105416140 hasConcept C24998067 @default.
• W2105416140 hasConcept C2776533406 @default.
• W2105416140 hasConcept C2778514916 @default.
• W2105416140 hasConcept C2779395532 @default.
• W2105416140 hasConcept C2992686903 @default.
• W2105416140 hasConcept C513476851 @default.
• W2105416140 hasConcept C519581460 @default.
• W2105416140 hasConcept C537181965 @default.
• W2105416140 hasConcept C71924100 @default.
• W2105416140 hasConcept C84393581 @default.
• W2105416140 hasConcept C86803240 @default.
• W2105416140 hasConceptScore W2105416140C126322002 @default.
• W2105416140 hasConceptScore W2105416140C134018914 @default.
• W2105416140 hasConceptScore W2105416140C178790620 @default.
• W2105416140 hasConceptScore W2105416140C185592680 @default.
• W2105416140 hasConceptScore W2105416140C188053792 @default.
• W2105416140 hasConceptScore W2105416140C24998067 @default.
• W2105416140 hasConceptScore W2105416140C2776533406 @default.
• W2105416140 hasConceptScore W2105416140C2778514916 @default.

• next