FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105421950> ?p ?o ?g. }

• W2105421950 abstract "Abstract Background Gaucher disease (GD) type I is the most common type of GD. Its main clinical manifestations are hepatosplenomegaly as well as bone and hematological abnormalities. The objective of the present study was to perform a literature review on the growth and metabolism of GD type I patients. Methods We searched Pubmed and Scielo.br databases with predetermined study limits: case series (n≥5), clinical trials, systematic reviews, and meta-analyses, and enzyme replacement therapy (ERT) with alglucerase or imiglucerase. The outcomes of interest were the following: growth and development, weight, height, malnutrition, overweight, obesity, basal metabolism, hypermetabolism, insulin resistance, and diabetes. A total of 175 articles were found, of which 28 met the inclusion criteria; these articles were grouped into three central themes: 1) growth of children and adolescents before and after ERT; 2) metabolic changes that remained during ERT; and 3) changes in metabolic status resulting from the treatment. Results and discussion The articles included in the present literature review are very heterogeneous, which hinders the analysis of data. They indicated that GD patients usually show low weight and height before ERT, which are improved with treatment in children and adolescents. Studies evaluating the energy metabolism by indirect calorimetry have indicated that the disease is associated with hypermetabolism. In adults, some changes in energy metabolism remain on ERT, and alterations, such as insulin resistance, seem to be associated with the treatment. It is not clear which are the required doses of imiglucerase for obtaining an adequate cost-effective relation, as well as the advisable therapeutic measures to avoid possible long-term adverse effects related to ERT. Conclusions ERT tends to normalise the growth of children and adolescents with GD type I, it seems to cause a partial response in relation to some metabolic changes associated with the disease, and it can causes metabolic changes such as weight gain in adult patients. Therefore, additional research is necessary." @default.
• W2105421950 created "2016-06-24" @default.
• W2105421950 creator A5021968370 @default.
• W2105421950 creator A5044929823 @default.
• W2105421950 creator A5076050376 @default.
• W2105421950 creator A5083543473 @default.
• W2105421950 date "2013-04-09" @default.
• W2105421950 modified "2023-10-16" @default.
• W2105421950 title "Effects of imiglucerase on the growth and metabolism of Gaucher disease type I patients: a systematic review" @default.
• W2105421950 cites W1974747412 @default.
• W2105421950 cites W1980496044 @default.
• W2105421950 cites W1989857232 @default.
• W2105421950 cites W1995892611 @default.
• W2105421950 cites W2005519754 @default.
• W2105421950 cites W2012157385 @default.
• W2105421950 cites W2023694220 @default.
• W2105421950 cites W2024930688 @default.
• W2105421950 cites W2024946008 @default.
• W2105421950 cites W2025927097 @default.
• W2105421950 cites W2031608061 @default.
• W2105421950 cites W2034300416 @default.
• W2105421950 cites W2045501106 @default.
• W2105421950 cites W2055100951 @default.
• W2105421950 cites W2057028178 @default.
• W2105421950 cites W2078624247 @default.
• W2105421950 cites W2079708079 @default.
• W2105421950 cites W2081779397 @default.
• W2105421950 cites W2088522082 @default.
• W2105421950 cites W2102755525 @default.
• W2105421950 cites W2104607370 @default.
• W2105421950 cites W2114362599 @default.
• W2105421950 cites W2125650673 @default.
• W2105421950 cites W2168077471 @default.
• W2105421950 cites W2168507439 @default.
• W2105421950 cites W4240242963 @default.
• W2105421950 cites W4242472906 @default.
• W2105421950 doi "https://doi.org/10.1186/1743-7075-10-34" @default.
• W2105421950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3630065" @default.
• W2105421950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23570288" @default.
• W2105421950 hasPublicationYear "2013" @default.
• W2105421950 type Work @default.
• W2105421950 sameAs 2105421950 @default.
• W2105421950 citedByCount "19" @default.
• W2105421950 countsByYear W21054219502013 @default.
• W2105421950 countsByYear W21054219502014 @default.
• W2105421950 countsByYear W21054219502015 @default.
• W2105421950 countsByYear W21054219502016 @default.
• W2105421950 countsByYear W21054219502018 @default.
• W2105421950 countsByYear W21054219502019 @default.
• W2105421950 countsByYear W21054219502020 @default.
• W2105421950 countsByYear W21054219502021 @default.
• W2105421950 countsByYear W21054219502022 @default.
• W2105421950 crossrefType "journal-article" @default.
• W2105421950 hasAuthorship W2105421950A5021968370 @default.
• W2105421950 hasAuthorship W2105421950A5044929823 @default.
• W2105421950 hasAuthorship W2105421950A5076050376 @default.
• W2105421950 hasAuthorship W2105421950A5083543473 @default.
• W2105421950 hasBestOaLocation W21054219501 @default.
• W2105421950 hasConcept C126322002 @default.
• W2105421950 hasConcept C134018914 @default.
• W2105421950 hasConcept C148257392 @default.
• W2105421950 hasConcept C187212893 @default.
• W2105421950 hasConcept C2777391703 @default.
• W2105421950 hasConcept C2777464067 @default.
• W2105421950 hasConcept C2779134260 @default.
• W2105421950 hasConcept C2779969927 @default.
• W2105421950 hasConcept C2780586474 @default.
• W2105421950 hasConcept C511355011 @default.
• W2105421950 hasConcept C544821477 @default.
• W2105421950 hasConcept C551997983 @default.
• W2105421950 hasConcept C71924100 @default.
• W2105421950 hasConceptScore W2105421950C126322002 @default.
• W2105421950 hasConceptScore W2105421950C134018914 @default.
• W2105421950 hasConceptScore W2105421950C148257392 @default.
• W2105421950 hasConceptScore W2105421950C187212893 @default.
• W2105421950 hasConceptScore W2105421950C2777391703 @default.
• W2105421950 hasConceptScore W2105421950C2777464067 @default.
• W2105421950 hasConceptScore W2105421950C2779134260 @default.
• W2105421950 hasConceptScore W2105421950C2779969927 @default.
• W2105421950 hasConceptScore W2105421950C2780586474 @default.
• W2105421950 hasConceptScore W2105421950C511355011 @default.
• W2105421950 hasConceptScore W2105421950C544821477 @default.
• W2105421950 hasConceptScore W2105421950C551997983 @default.
• W2105421950 hasConceptScore W2105421950C71924100 @default.
• W2105421950 hasIssue "1" @default.
• W2105421950 hasLocation W21054219501 @default.
• W2105421950 hasLocation W21054219502 @default.
• W2105421950 hasLocation W21054219503 @default.
• W2105421950 hasLocation W21054219504 @default.
• W2105421950 hasLocation W21054219505 @default.
• W2105421950 hasOpenAccess W2105421950 @default.
• W2105421950 hasPrimaryLocation W21054219501 @default.
• W2105421950 hasRelatedWork W1979252938 @default.
• W2105421950 hasRelatedWork W2032225465 @default.
• W2105421950 hasRelatedWork W2169206971 @default.
• W2105421950 hasRelatedWork W2378290744 @default.
• W2105421950 hasRelatedWork W2584731720 @default.
• W2105421950 hasRelatedWork W2886303208 @default.
• W2105421950 hasRelatedWork W2910989958 @default.
• W2105421950 hasRelatedWork W2969331335 @default.

• next