FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105429678> ?p ?o ?g. }

• W2105429678 endingPage "274" @default.
• W2105429678 startingPage "270" @default.
• W2105429678 abstract "Although the role of nitric oxide (NO) in the modulation of vascular tone has been studied and well understood, its potential role in the control of myocardial metabolism is only recently evident. Several lines of evidence indicate that NO regulates myocardial glucose metabolism; however, the details and mechanisms responsible are still unknown. The aim of this study was to further define the role of NO in the control of myocardial glucose metabolism and the nitric oxide synthase (NOS) isoform responsible using transgenic animals lacking endothelial NOS (ecNOS). In the present study, we examined the regulation of myocardial glucose uptake using isometrically contracting Langendorff-perfused hearts from normal mice (C57BL/6J), mice with defects in the expression of ecNOS [ecNOS (-/-)], and its heterozygote [ecNOS (+/-)], and wild-type mice [ecNOS (+/+)] (n=6, respectively). In hearts from normal mice, little myocardial glucose uptake was observed. This myocardial glucose uptake increased significantly in the presence of N(omega)-nitro-L-arginine methyl ester (L-NAME). Similarly, in the hearts from ecNOS (-/-), glucose uptake was much greater than in normal mice, whereas myocardial glucose uptake of ecNOS (+/-) and ecNOS (+/+) mice was not different from normal mice. In addition, myocardial glucose uptake of ecNOS (+/-) and ecNOS (+/+) mice increased significantly in the presence of L-NAME. At a workload of 800 g. beats/min, L-NAME increased glucose uptake from 0.1+/-0.1 to 3+/-0.4 microg/min x mg in ecNOS (+/-) mice and from 0.2+/-0.1 to 2.7+/-0.7 microg/min x mg in ecNOS (+/+) mice. Furthermore, in the hearts from ecNOS (-/-) mice, 8-bromoguanosine 3':5'-cyclic monophosphate (8-Br-cGMP), a cGMP analog or S-nitroso-N-acetylpenicillamine (SNAP), a NO donor essentially shut off glucose uptake, and in hearts from ecNOS (+/-) mice, 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ), an inhibitor of cGMP, increased the glucose uptake significantly. These results indicate clearly that cardiac NO production regulates myocardial glucose uptake via a cGMP-dependent mechanism and strongly suggest that ecNOS plays a pivotal role in this regulation. These findings may be important in the understanding of the pathogenesis of the diseases such as ischemic heart disease, heart failure, diabetes mellitus, hypertension, and hypercholesterolemia, in which NO synthesis is altered and substrate utilization by the heart changes." @default.
• W2105429678 created "2016-06-24" @default.
• W2105429678 creator A5000791777 @default.
• W2105429678 creator A5009822156 @default.
• W2105429678 creator A5022973245 @default.
• W2105429678 creator A5048625389 @default.
• W2105429678 creator A5072064465 @default.
• W2105429678 creator A5073689981 @default.
• W2105429678 creator A5074912244 @default.
• W2105429678 creator A5082549212 @default.
• W2105429678 creator A5083216340 @default.
• W2105429678 date "2000-02-18" @default.
• W2105429678 modified "2023-09-27" @default.
• W2105429678 title "Myocardial Glucose Uptake Is Regulated by Nitric Oxide via Endothelial Nitric Oxide Synthase in Langendorff Mouse Heart" @default.
• W2105429678 cites W1523151859 @default.
• W2105429678 cites W1528220495 @default.
• W2105429678 cites W1983069625 @default.
• W2105429678 cites W2030962213 @default.
• W2105429678 cites W2047545717 @default.
• W2105429678 cites W2067637944 @default.
• W2105429678 cites W2091499945 @default.
• W2105429678 cites W2166506332 @default.
• W2105429678 cites W2169182236 @default.
• W2105429678 cites W2172907597 @default.
• W2105429678 doi "https://doi.org/10.1161/01.res.86.3.270" @default.
• W2105429678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10679477" @default.
• W2105429678 hasPublicationYear "2000" @default.
• W2105429678 type Work @default.
• W2105429678 sameAs 2105429678 @default.
• W2105429678 citedByCount "74" @default.
• W2105429678 countsByYear W21054296782012 @default.
• W2105429678 countsByYear W21054296782013 @default.
• W2105429678 countsByYear W21054296782015 @default.
• W2105429678 countsByYear W21054296782016 @default.
• W2105429678 countsByYear W21054296782017 @default.
• W2105429678 countsByYear W21054296782019 @default.
• W2105429678 countsByYear W21054296782020 @default.
• W2105429678 countsByYear W21054296782022 @default.
• W2105429678 countsByYear W21054296782023 @default.
• W2105429678 crossrefType "journal-article" @default.
• W2105429678 hasAuthorship W2105429678A5000791777 @default.
• W2105429678 hasAuthorship W2105429678A5009822156 @default.
• W2105429678 hasAuthorship W2105429678A5022973245 @default.
• W2105429678 hasAuthorship W2105429678A5048625389 @default.
• W2105429678 hasAuthorship W2105429678A5072064465 @default.
• W2105429678 hasAuthorship W2105429678A5073689981 @default.
• W2105429678 hasAuthorship W2105429678A5074912244 @default.
• W2105429678 hasAuthorship W2105429678A5082549212 @default.
• W2105429678 hasAuthorship W2105429678A5083216340 @default.
• W2105429678 hasBestOaLocation W21054296781 @default.
• W2105429678 hasConcept C126322002 @default.
• W2105429678 hasConcept C134018914 @default.
• W2105429678 hasConcept C17093226 @default.
• W2105429678 hasConcept C185592680 @default.
• W2105429678 hasConcept C2776992346 @default.
• W2105429678 hasConcept C2777622882 @default.
• W2105429678 hasConcept C2778326061 @default.
• W2105429678 hasConcept C2908688039 @default.
• W2105429678 hasConcept C519581460 @default.
• W2105429678 hasConcept C71924100 @default.
• W2105429678 hasConceptScore W2105429678C126322002 @default.
• W2105429678 hasConceptScore W2105429678C134018914 @default.
• W2105429678 hasConceptScore W2105429678C17093226 @default.
• W2105429678 hasConceptScore W2105429678C185592680 @default.
• W2105429678 hasConceptScore W2105429678C2776992346 @default.
• W2105429678 hasConceptScore W2105429678C2777622882 @default.
• W2105429678 hasConceptScore W2105429678C2778326061 @default.
• W2105429678 hasConceptScore W2105429678C2908688039 @default.
• W2105429678 hasConceptScore W2105429678C519581460 @default.
• W2105429678 hasConceptScore W2105429678C71924100 @default.
• W2105429678 hasIssue "3" @default.
• W2105429678 hasLocation W21054296781 @default.
• W2105429678 hasLocation W21054296782 @default.
• W2105429678 hasOpenAccess W2105429678 @default.
• W2105429678 hasPrimaryLocation W21054296781 @default.
• W2105429678 hasRelatedWork W2003811568 @default.
• W2105429678 hasRelatedWork W2008087125 @default.
• W2105429678 hasRelatedWork W2021330452 @default.
• W2105429678 hasRelatedWork W2036533624 @default.
• W2105429678 hasRelatedWork W2040115114 @default.
• W2105429678 hasRelatedWork W2063441939 @default.
• W2105429678 hasRelatedWork W2082995727 @default.
• W2105429678 hasRelatedWork W2089295326 @default.
• W2105429678 hasRelatedWork W2091715834 @default.
• W2105429678 hasRelatedWork W2093911704 @default.
• W2105429678 hasVolume "86" @default.
• W2105429678 isParatext "false" @default.
• W2105429678 isRetracted "false" @default.
• W2105429678 magId "2105429678" @default.
• W2105429678 workType "article" @default.