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- W2105444889 abstract "Clinical assessment of the respiratory function is critical in amyotrophic lateral sclerosis (ALS). A standardized process is to monitor the respiratory subscore of the revised ALSFRS (RofALSFRS-R). We tested the utility of RofALSFRS-R and its individual questions in evaluating respiratory functionality. Three hundred and fifty-seven consecutive ALS patients were assessed at entry (T0), three and six months later (T1 and T2). ALSFRS and its subscores decayed significantly (p < 0.001) over time. Improvement in the first respiratory question (dyspnoea, QR1) was found in about 10% of the patients in each period. Between T0 and T1 a significant negative correlation was found between decrease in gait score and QR1 (p = 0.021, r = –0.395) in the subgroup of ALS patients who showed QR1 improvement (n = 34). An improvement in the other respiratory questions was noticed in about 6% of the patients, related to non-invasive ventilation. Possibly, decreased mobility and metabolic demand can cause fewer respiratory symptoms in a subset of patients. The respiratory questions included in ALSFRS-R should be re-addressed by the ALS community." @default.
- W2105444889 created "2016-06-24" @default.
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- W2105444889 date "2014-09-10" @default.
- W2105444889 modified "2023-10-11" @default.
- W2105444889 title "The R of ALSFRS-R: Does it really mirror functional respiratory involvement in amyotrophic lateral sclerosis?" @default.
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- W2105444889 doi "https://doi.org/10.3109/21678421.2014.952641" @default.
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