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• W2105446887 abstract "Abstract Cutaneous lymphoproliferative diseases encompass a spectrum of lesions, ranging from self‐limiting, reactive infiltrates to high‐grade lymphomas. In humans, cutaneous lymphocytosis (CL) refers to self‐limiting or slowly progressive monomorphic lymphocytic infiltrates of mostly unknown cause. It morphologically mimics cutaneous lymphoma. CL in cats also is a slowly progressive disease. Immunophenotyping and clonality testing of feline CL support an indolent lymphoma for the majority of cases studied. This study reports CL in dogs. Erythematous, scaly and alopecic macules, patches or plaques were present in eight dogs. Breed predilection was not observed; six of eight dogs were females; and ages ranged from 5 to 14 years. Diffuse monomorphic non‐epitheliotropic infiltrates of CD3 + (eight of eight), CD45 − (four of eight) or CD45 +/− (four of eight) and CD45RA − (seven of eight) T lymphocytes were present in the superficial and mid‐dermis. Further immunophenotyping of five cases revealed TCR‐γδ + T cells (one of five) or TCR‐αβ + (four of five) T cells. TCR‐αβ + populations were either CD8 + (two of four) or CD4 − CD8 − (2/4). Clonality testing found clonal (seven of eight) or pseudoclonal (one of eight) rearrangement of the TCR‐gamma locus of the lesional T cells. Prednisone, prednisolone and methylprednisolone acetate were the most commonly administered drugs. The lesions remained stable for long periods up to 6 years. Five dogs were euthanized due to progression of the skin lesions (three of five), peripheral lymphadenopathy of unknown origin (one of five) or high‐grade lymphoma (one of five). One dog was lost for follow‐up and two dogs are still alive (17 and 9 months after diagnosis). Canine CL is best considered an initially indolent lymphoma, with slow progression and a potential for progression to high‐grade lymphoma." @default.
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• W2105446887 date "2009-10-01" @default.
• W2105446887 modified "2023-10-15" @default.
• W2105446887 title "Indolent cutaneous T‐cell lymphoma presenting as cutaneous lymphocytosis in dogs" @default.
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• W2105446887 doi "https://doi.org/10.1111/j.1365-3164.2009.00833.x" @default.
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