FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105448545> ?p ?o ?g. }

• W2105448545 endingPage "79" @default.
• W2105448545 startingPage "70" @default.
• W2105448545 abstract "Expression of NK cell markers identifies pro-inflammatory T cell subsets in the liver and intestinal immune compartments. Specifically, CD161 is expressed on Th17 cells which play an important role in the regulation of mucosal inflammation. In this study, we characterized human peripheral blood CD161+ T cells as an effector population partially resembling a gut T cell phenotype. CD161+ CD4+ T cells express the gut-associated TNF family member, LIGHT, and respond to crosslinking of DR3, a receptor to another gut-associated cytokine, TL1A. Robust IFN-γ production in response to DR3 signaling correlated with enhanced expression of surface DR3 on CD161+ T cells and co-stimulation with IL12 and IL18. CD161+ T cell effector function was directly demonstrated by activation of responder monocytes in co-culture leading to CD40 upregulation and CD14 downregulation. CD161+ T cells reciprocally responded to activated monocytes, inducing expression of activation marker, CD69, and production of IL2 and IFN-γ, further demonstrating effective CD161+ T cell cross-talk with monocytes. Finally, CD161 defined a subset of T cells that co-express CD56, a second NK marker. Our findings implicate human CD161+ T cells in gut-associated signaling mechanisms, and suggest a monocyte mediated effector function in mucosal inflammation." @default.
• W2105448545 created "2016-06-24" @default.
• W2105448545 creator A5051870878 @default.
• W2105448545 creator A5053448553 @default.
• W2105448545 creator A5054640013 @default.
• W2105448545 creator A5069383224 @default.
• W2105448545 creator A5086622114 @default.
• W2105448545 date "2011-03-01" @default.
• W2105448545 modified "2023-09-26" @default.
• W2105448545 title "CD161 defines effector T cells that express light and respond to TL1A-DR3 signaling" @default.
• W2105448545 cites W1491757778 @default.
• W2105448545 cites W1492770235 @default.
• W2105448545 cites W1494732560 @default.
• W2105448545 cites W1522160743 @default.
• W2105448545 cites W1578322024 @default.
• W2105448545 cites W1671125472 @default.
• W2105448545 cites W1822393190 @default.
• W2105448545 cites W1852227421 @default.
• W2105448545 cites W1954055770 @default.
• W2105448545 cites W1971104055 @default.
• W2105448545 cites W1972195950 @default.
• W2105448545 cites W1975164490 @default.
• W2105448545 cites W1979787704 @default.
• W2105448545 cites W1982935446 @default.
• W2105448545 cites W1989604103 @default.
• W2105448545 cites W1995943031 @default.
• W2105448545 cites W2012041771 @default.
• W2105448545 cites W2014373584 @default.
• W2105448545 cites W2019072949 @default.
• W2105448545 cites W2021847144 @default.
• W2105448545 cites W2023828666 @default.
• W2105448545 cites W2041442644 @default.
• W2105448545 cites W2044994496 @default.
• W2105448545 cites W2046486403 @default.
• W2105448545 cites W2048464548 @default.
• W2105448545 cites W2056167691 @default.
• W2105448545 cites W2070869625 @default.
• W2105448545 cites W2072380594 @default.
• W2105448545 cites W2078309830 @default.
• W2105448545 cites W2087108779 @default.
• W2105448545 cites W2087221993 @default.
• W2105448545 cites W2090631845 @default.
• W2105448545 cites W2093247535 @default.
• W2105448545 cites W2096924175 @default.
• W2105448545 cites W2110883977 @default.
• W2105448545 cites W2113765407 @default.
• W2105448545 cites W2117670724 @default.
• W2105448545 cites W2137167164 @default.
• W2105448545 cites W2147172932 @default.
• W2105448545 cites W2150802568 @default.
• W2105448545 cites W2153222324 @default.
• W2105448545 cites W2160708353 @default.
• W2105448545 cites W2161753987 @default.
• W2105448545 cites W2161890468 @default.
• W2105448545 cites W2163341474 @default.
• W2105448545 cites W2165910525 @default.
• W2105448545 cites W2171297959 @default.
• W2105448545 cites W2171525876 @default.
• W2105448545 cites W2321453230 @default.
• W2105448545 cites W4242818520 @default.
• W2105448545 doi "https://doi.org/10.1556/eujmi.1.2011.1.9" @default.
• W2105448545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3279928" @default.
• W2105448545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22348196" @default.
• W2105448545 hasPublicationYear "2011" @default.
• W2105448545 type Work @default.
• W2105448545 sameAs 2105448545 @default.
• W2105448545 citedByCount "17" @default.
• W2105448545 countsByYear W21054485452012 @default.
• W2105448545 countsByYear W21054485452013 @default.
• W2105448545 countsByYear W21054485452014 @default.
• W2105448545 countsByYear W21054485452015 @default.
• W2105448545 countsByYear W21054485452016 @default.
• W2105448545 countsByYear W21054485452017 @default.
• W2105448545 countsByYear W21054485452019 @default.
• W2105448545 countsByYear W21054485452021 @default.
• W2105448545 crossrefType "journal-article" @default.
• W2105448545 hasAuthorship W2105448545A5051870878 @default.
• W2105448545 hasAuthorship W2105448545A5053448553 @default.
• W2105448545 hasAuthorship W2105448545A5054640013 @default.
• W2105448545 hasAuthorship W2105448545A5069383224 @default.
• W2105448545 hasAuthorship W2105448545A5086622114 @default.
• W2105448545 hasBestOaLocation W21054485452 @default.
• W2105448545 hasConcept C104317684 @default.
• W2105448545 hasConcept C127561419 @default.
• W2105448545 hasConcept C129374314 @default.
• W2105448545 hasConcept C154317977 @default.
• W2105448545 hasConcept C202751555 @default.
• W2105448545 hasConcept C203014093 @default.
• W2105448545 hasConcept C2776090121 @default.
• W2105448545 hasConcept C2776914184 @default.
• W2105448545 hasConcept C2778513237 @default.
• W2105448545 hasConcept C2778690821 @default.
• W2105448545 hasConcept C2781184567 @default.
• W2105448545 hasConcept C2908647359 @default.
• W2105448545 hasConcept C39347974 @default.
• W2105448545 hasConcept C51785407 @default.
• W2105448545 hasConcept C55493867 @default.
• W2105448545 hasConcept C71924100 @default.

• next