FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105448554> ?p ?o ?g. }

• W2105448554 endingPage "468" @default.
• W2105448554 startingPage "458" @default.
• W2105448554 abstract "The DNA damage response (DDR) is activated upon DNA damage and prevents accumulation of mutations and chromosomal rearrangements, both driving carcinogenesis. Tumor cells often have defects in the DDR, which in combination with continuous cell proliferation are exploited by genotoxic cancer therapies. Most cancers, overcome initial sensitivity and develop drug resistance, e.g. by modulation of the DDR. Not much is known, however, about DNA damage responsive microRNAs in cancer therapy resistance. Therefore, we mapped temporal microRNA expression changes in primary breast epithelial cells upon low and high dose exposure to the DNA damaging agents ionizing radiation and cisplatin. A third of all DDR microRNAs commonly regulated across all treatments was also misexpressed in breast cancer, indicating a DDR defect. We repeated this approach in primary lung epithelial cells and non-small cell lung cancer samples and found that more than 40% of all DDR microRNAs was deregulated in non-small cell lung cancer. Strikingly, the microRNA response upon genotoxic stress in primary breast and lung epithelial cells was markedly different, although the biological outcome of DNA damage signaling (cell death/senescence or survival) was similar. Several DDR microRNAs deregulated in cancer modulated sensitivity to anti-cancer agents. In addition we were able to distinguish between microRNAs that induced resistance by potentially inducing quiescence (miR-296-5p and miR-382) or enhancing DNA repair or increased DNA damage tolerance (miR-21). In conclusion, we provide evidence that DNA damage responsive microRNAs are frequently misexpressed in human cancer and can modulate chemotherapy sensitivity." @default.
• W2105448554 created "2016-06-24" @default.
• W2105448554 creator A5013888438 @default.
• W2105448554 creator A5044475780 @default.
• W2105448554 creator A5048330851 @default.
• W2105448554 creator A5052209499 @default.
• W2105448554 creator A5060948679 @default.
• W2105448554 creator A5066926133 @default.
• W2105448554 creator A5071991781 @default.
• W2105448554 creator A5073858631 @default.
• W2105448554 creator A5074174053 @default.
• W2105448554 creator A5077531941 @default.
• W2105448554 creator A5085813010 @default.
• W2105448554 date "2013-12-31" @default.
• W2105448554 modified "2023-10-15" @default.
• W2105448554 title "DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity" @default.
• W2105448554 cites W1951430679 @default.
• W2105448554 cites W1963596347 @default.
• W2105448554 cites W1970760326 @default.
• W2105448554 cites W1975308625 @default.
• W2105448554 cites W1979261061 @default.
• W2105448554 cites W1980438635 @default.
• W2105448554 cites W1982602899 @default.
• W2105448554 cites W1986761262 @default.
• W2105448554 cites W1988280121 @default.
• W2105448554 cites W1990645475 @default.
• W2105448554 cites W1996361117 @default.
• W2105448554 cites W2000093333 @default.
• W2105448554 cites W2002962154 @default.
• W2105448554 cites W2003624918 @default.
• W2105448554 cites W2008932845 @default.
• W2105448554 cites W2010417927 @default.
• W2105448554 cites W2013721931 @default.
• W2105448554 cites W2016004402 @default.
• W2105448554 cites W2026270542 @default.
• W2105448554 cites W2030795773 @default.
• W2105448554 cites W2059971436 @default.
• W2105448554 cites W2066868410 @default.
• W2105448554 cites W2070031183 @default.
• W2105448554 cites W2071735670 @default.
• W2105448554 cites W2074730941 @default.
• W2105448554 cites W2081297751 @default.
• W2105448554 cites W2082559623 @default.
• W2105448554 cites W2092215602 @default.
• W2105448554 cites W2093905827 @default.
• W2105448554 cites W2096707644 @default.
• W2105448554 cites W2101698500 @default.
• W2105448554 cites W2106391833 @default.
• W2105448554 cites W2107882011 @default.
• W2105448554 cites W2109637975 @default.
• W2105448554 cites W2117692326 @default.
• W2105448554 cites W2125988618 @default.
• W2105448554 cites W2127617517 @default.
• W2105448554 cites W2128032802 @default.
• W2105448554 cites W2131595467 @default.
• W2105448554 cites W2135810600 @default.
• W2105448554 cites W2146907783 @default.
• W2105448554 cites W2149178140 @default.
• W2105448554 cites W2162674813 @default.
• W2105448554 cites W2165125584 @default.
• W2105448554 cites W2165837717 @default.
• W2105448554 cites W2169302611 @default.
• W2105448554 cites W3023299375 @default.
• W2105448554 cites W4294107304 @default.
• W2105448554 cites W45534775 @default.
• W2105448554 doi "https://doi.org/10.1016/j.molonc.2013.12.011" @default.
• W2105448554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4685152" @default.
• W2105448554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24462518" @default.
• W2105448554 hasPublicationYear "2013" @default.
• W2105448554 type Work @default.
• W2105448554 sameAs 2105448554 @default.
• W2105448554 citedByCount "43" @default.
• W2105448554 countsByYear W21054485542014 @default.
• W2105448554 countsByYear W21054485542015 @default.
• W2105448554 countsByYear W21054485542016 @default.
• W2105448554 countsByYear W21054485542017 @default.
• W2105448554 countsByYear W21054485542018 @default.
• W2105448554 countsByYear W21054485542019 @default.
• W2105448554 countsByYear W21054485542020 @default.
• W2105448554 countsByYear W21054485542021 @default.
• W2105448554 countsByYear W21054485542022 @default.
• W2105448554 countsByYear W21054485542023 @default.
• W2105448554 crossrefType "journal-article" @default.
• W2105448554 hasAuthorship W2105448554A5013888438 @default.
• W2105448554 hasAuthorship W2105448554A5044475780 @default.
• W2105448554 hasAuthorship W2105448554A5048330851 @default.
• W2105448554 hasAuthorship W2105448554A5052209499 @default.
• W2105448554 hasAuthorship W2105448554A5060948679 @default.
• W2105448554 hasAuthorship W2105448554A5066926133 @default.
• W2105448554 hasAuthorship W2105448554A5071991781 @default.
• W2105448554 hasAuthorship W2105448554A5073858631 @default.
• W2105448554 hasAuthorship W2105448554A5074174053 @default.
• W2105448554 hasAuthorship W2105448554A5077531941 @default.
• W2105448554 hasAuthorship W2105448554A5085813010 @default.
• W2105448554 hasBestOaLocation W21054485541 @default.
• W2105448554 hasConcept C104317684 @default.
• W2105448554 hasConcept C121608353 @default.
• W2105448554 hasConcept C134935766 @default.

• next