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- W2105454954 abstract "The early recognition of cardiac ischemia and accurate placement of the patient in the risk spectrum of the acute coronary syndrome are critical to the effective management of patients with acute myocardial infarction (AMI). Apart from clinical history, physical examination and accurate ECG interpretations, cardiac biomarkers are equally valuable in the initial evaluation of patients with nontraumatic chest pain. Previously the diagnosis of an AMI was based on World Health Organisation (WHO) criteria which defined MI as the presence of two out of three characteristics comprising: symptoms of acute ischemia (chest pain), development of Q waves in ECG and elevated activities of traditional serum enzymes comprising: total CK, CK-MB, ASAT and LDH. An ideal biomarker should have the following characteristics: relatively high concentration within cardiac tissue, have no significant tissue sources other than the heart, have high clinical sensitivity and specificity, be detectable in the blood early after the onset of chest pain, have elevated blood levels for several days after the onset of symptoms, and have an assay with a quick turnaround time. Since no single biomarker fulfils all of these criteria, the NACB proposes the use of two biomarkers for the diagnosis of AMI: an early marker – myoglobin and a definitive marker- cardiac troponins. When cardiac troponin is not available, the next best alternative is CK-MB (measured by mass assay)." @default.
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- W2105454954 date "2005-01-01" @default.
- W2105454954 modified "2023-09-27" @default.
- W2105454954 title "LABORATORY DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION" @default.
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