Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105455857> ?p ?o ?g. }
- W2105455857 endingPage "306" @default.
- W2105455857 startingPage "298" @default.
- W2105455857 abstract "Hairy-related proteins are a distinct subfamily of basic helix-loop-helix (bHLH) proteins that generally function as DNA-binding transcriptional repressors. These proteins act in opposition to bHLH transcriptional activator proteins such as the proneural and myogenic proteins; together, the activator and repressor genes that encode these proteins have co-evolved as a regulatory gene “cassette” or “module” for controlling cell fate decisions. In the development of the Drosophila peripheral nervous system, Hairy-related genes function at multiple steps during neurogenesis, for example, as positional information genes that establish the “prepattern” that controls where “proneural cluster” equivalence groups will form, and later as nuclear effectors of the Notch signaling pathway to “single out” individual precursor cells within the equivalence group. Hairy-related genes also function in the establishment and restriction of other types of equivalence groups, such as those for muscle and Malphigian tubule precursors. This general function in cell fate specification has been conserved from Drosophila to vertebrates and has implications for human disease pathogenesis. BioEssays 20:298-306, 1998.© 1998 John Wiley & Sons, Inc." @default.
- W2105455857 created "2016-06-24" @default.
- W2105455857 creator A5069723892 @default.
- W2105455857 creator A5088094053 @default.
- W2105455857 date "1998-12-06" @default.
- W2105455857 modified "2023-10-15" @default.
- W2105455857 title "The function of hairy-related bHLH repressor proteins in cell fate decisions" @default.
- W2105455857 cites W114884692 @default.
- W2105455857 cites W145923327 @default.
- W2105455857 cites W1548690239 @default.
- W2105455857 cites W1560143429 @default.
- W2105455857 cites W1589139546 @default.
- W2105455857 cites W1589317498 @default.
- W2105455857 cites W1592915406 @default.
- W2105455857 cites W1607603936 @default.
- W2105455857 cites W1765030823 @default.
- W2105455857 cites W1790815665 @default.
- W2105455857 cites W1807161409 @default.
- W2105455857 cites W1844615320 @default.
- W2105455857 cites W1894504172 @default.
- W2105455857 cites W1966686416 @default.
- W2105455857 cites W1967192173 @default.
- W2105455857 cites W1978089479 @default.
- W2105455857 cites W1978779470 @default.
- W2105455857 cites W1984425610 @default.
- W2105455857 cites W1987084599 @default.
- W2105455857 cites W1990045619 @default.
- W2105455857 cites W1997350479 @default.
- W2105455857 cites W1997955636 @default.
- W2105455857 cites W1999529317 @default.
- W2105455857 cites W2002300136 @default.
- W2105455857 cites W2003927747 @default.
- W2105455857 cites W2006535640 @default.
- W2105455857 cites W2007038051 @default.
- W2105455857 cites W2007339100 @default.
- W2105455857 cites W2010287515 @default.
- W2105455857 cites W2016213943 @default.
- W2105455857 cites W2021379447 @default.
- W2105455857 cites W2025034500 @default.
- W2105455857 cites W2025748388 @default.
- W2105455857 cites W2025804504 @default.
- W2105455857 cites W2026455684 @default.
- W2105455857 cites W2027128159 @default.
- W2105455857 cites W2027971163 @default.
- W2105455857 cites W2040112346 @default.
- W2105455857 cites W2040994502 @default.
- W2105455857 cites W2041401980 @default.
- W2105455857 cites W2043408306 @default.
- W2105455857 cites W2047483221 @default.
- W2105455857 cites W2056069458 @default.
- W2105455857 cites W2056652163 @default.
- W2105455857 cites W2062654403 @default.
- W2105455857 cites W2075706983 @default.
- W2105455857 cites W2082530227 @default.
- W2105455857 cites W2083280774 @default.
- W2105455857 cites W2083723382 @default.
- W2105455857 cites W2084520007 @default.
- W2105455857 cites W2091496842 @default.
- W2105455857 cites W2098867949 @default.
- W2105455857 cites W2102473622 @default.
- W2105455857 cites W2103886590 @default.
- W2105455857 cites W2107740756 @default.
- W2105455857 cites W2108073709 @default.
- W2105455857 cites W2109099832 @default.
- W2105455857 cites W2109126669 @default.
- W2105455857 cites W2115861317 @default.
- W2105455857 cites W2118589362 @default.
- W2105455857 cites W2118640882 @default.
- W2105455857 cites W2124025927 @default.
- W2105455857 cites W2128292585 @default.
- W2105455857 cites W2138122506 @default.
- W2105455857 cites W2138301962 @default.
- W2105455857 cites W2141995159 @default.
- W2105455857 cites W2144868620 @default.
- W2105455857 cites W2150045641 @default.
- W2105455857 cites W2152046097 @default.
- W2105455857 cites W2153838631 @default.
- W2105455857 cites W2155186791 @default.
- W2105455857 cites W2155365827 @default.
- W2105455857 cites W2158499654 @default.
- W2105455857 cites W2168875465 @default.
- W2105455857 cites W2169580261 @default.
- W2105455857 cites W2181739110 @default.
- W2105455857 cites W2221138734 @default.
- W2105455857 cites W2288761659 @default.
- W2105455857 cites W2315075389 @default.
- W2105455857 cites W231822359 @default.
- W2105455857 cites W2417380734 @default.
- W2105455857 cites W4210958860 @default.
- W2105455857 doi "https://doi.org/10.1002/(sici)1521-1878(199804)20:4<298::aid-bies6>3.0.co;2-m" @default.
- W2105455857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9619101" @default.
- W2105455857 hasPublicationYear "1998" @default.
- W2105455857 type Work @default.
- W2105455857 sameAs 2105455857 @default.
- W2105455857 citedByCount "212" @default.
- W2105455857 countsByYear W21054558572012 @default.
- W2105455857 countsByYear W21054558572013 @default.
- W2105455857 countsByYear W21054558572014 @default.