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• W2105461608 endingPage "7558" @default.
• W2105461608 startingPage "7550" @default.
• W2105461608 abstract "Leptospira borgpetersenii serovar hardjo is the most common cause of bovine leptospirosis and also causes zoonotic infections of humans. A protective killed vaccine against serovar hardjo was shown to induce strong antigen-specific proliferative responses by peripheral blood mononuclear cells (PBMC) from vaccinated cattle by 2 months after the first dose of vaccine. This response was absent from nonvaccinated control cattle. The mean response peaked by 2 months after completion of the two-dose vaccination regimen, and substantial proliferation was measured in in vitro cultures throughout the 7 months of the study period. Variations in magnitude of the response occurred among the vaccinated animals, but by 7 months postvaccination there was a substantial antigen-specific response with PBMC from all vaccinated animals. Up to one-third of the PBMC from vaccinated animals produced gamma interferon (IFN-gamma) after 7 days in culture with antigen, as ascertained by flow cytometric analysis, and significant levels of IFN-gamma were measured in culture supernatants by enzyme-linked immunosorbent assay. Two-color immunofluorescence revealed that one-third of the IFN-gamma-producing cells were gammadelta T cells, with the remaining cells being CD4(+) T cells. The significance of this study is the very potent Th1-type immune response induced and sustained following vaccination with a killed bacterial vaccine adjuvanted with aluminum hydroxide and the involvement of gammadelta T cells in the response. Moreover, induction of this Th1-type cellular immune response is associated with the protection afforded by the bovine leptospiral vaccine against L. borgpetersenii serovar hardjo." @default.
• W2105461608 created "2016-06-24" @default.
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• W2105461608 date "2001-12-01" @default.
• W2105461608 modified "2023-10-18" @default.
• W2105461608 title "Protective Killed<i>Leptospira borgpetersenii</i>Vaccine Induces Potent Th1 Immunity Comprising Responses by CD4 and γδ T Lymphocytes" @default.
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• W2105461608 doi "https://doi.org/10.1128/iai.69.12.7550-7558.2001" @default.
• W2105461608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/98846" @default.
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