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- W2105467758 abstract "Central pontine myelinolysis and extrapontine myelinolysis are characterized by symmetric demyelination subsequent to rapid shifts in serum osmolality. Described here is a novel case of transient cortical blindness in association with imaging features of extrapontine myelinolysis, which occurred in a child with carbamoyl phosphate synthetase deficiency after rapid correction of hyperammonemia. Serum sodium levels were within normal limits at presentation and throughout the period of ammonia correction. A potential pathogenic mechanism of osmotic demyelination in the setting of acute treatment for hyperammonemia in a patient with a urea cycle abnormality includes disruption of the blood-brain barrier and re-equilibration of organic osmolytes, particularly glutamine." @default.
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- W2105467758 date "2010-02-01" @default.
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- W2105467758 title "Extrapontine Myelinolysis Resulting in Transient Cortical Blindness" @default.
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- W2105467758 doi "https://doi.org/10.1016/j.pediatrneurol.2009.08.012" @default.
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