FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105470010> ?p ?o ?g. }

• W2105470010 endingPage "639" @default.
• W2105470010 startingPage "627" @default.
• W2105470010 abstract "A growing body of anecdotal evidence in young and adult humans suggests that certain phytochemicals have the capacity to ameliorate tumors and reduce infections, especially those mediated by virus, in vivo. These indications prompted us, therefore, to investigate the potentially immuno-stimulating effect of one such phytocompound, Echinacea purpurea, on natural killer (NK) cells since these cells are active in spontaneous, non-specific immunity against neoplasms and virus-mediated infections. We elected to study aging mice, since, at this stage of life, like humans, the above-mentioned afflictions increase in frequency. We had previously found that neither the cytokine, interleukin-2, nor the pharmacological agent, indomethacin, both potent stimulators of NK cell numbers/function in younger adult mice, was effective in stimulating NK cells in elderly mice. The present study was designed to assess the numbers/production of NK cells in the spleen and bone marrow of aging, normal mice, after in vivo dietary administration of E. purpurea (14 days), or, after injection of thyroxin, a stimulant of NK cell function (10 days). Immunoperoxidase labeling techniques, coupled with hematologic tetrachrome staining were used to identify NK cells in both the spleen (primary site of NK cell function) and the bone marrow (site of NK cell generation). Double immunofluorscence staining, employing propidium iodide, was used to assess NK cell lytic function. Our results revealed that E. purpurea, but not thyroxin, had the capacity to increase NK cell numbers, in aging mice, reflecting increased new NK cell production in their bone marrow generation site, leading to an increase in the absolute numbers of NK cells in the spleen, their primary destiny. The E. purpurea-mediated increase in NK cell numbers was indeed paralleled by an increase in their anti-tumor, lytic functional capacity. Collectively, the data indicate that E. purpurea, at least, and possibly other plant compounds, appear to contain phytochemicals capable of stimulating de novo production of NK cells, as well as augmenting their cytolytic function, in animals of advanced age." @default.
• W2105470010 created "2016-06-24" @default.
• W2105470010 creator A5050117064 @default.
• W2105470010 creator A5083640496 @default.
• W2105470010 date "2000-08-01" @default.
• W2105470010 modified "2023-10-18" @default.
• W2105470010 title "Natural killer cells from aging mice treated with extracts from Echinacea purpurea are quantitatively and functionally rejuvenated" @default.
• W2105470010 cites W123855573 @default.
• W2105470010 cites W1509726375 @default.
• W2105470010 cites W1549355081 @default.
• W2105470010 cites W1554279410 @default.
• W2105470010 cites W1563075775 @default.
• W2105470010 cites W1571629593 @default.
• W2105470010 cites W1577032157 @default.
• W2105470010 cites W1608435254 @default.
• W2105470010 cites W167601316 @default.
• W2105470010 cites W1903223072 @default.
• W2105470010 cites W1950166256 @default.
• W2105470010 cites W1977009417 @default.
• W2105470010 cites W1977956268 @default.
• W2105470010 cites W1981503997 @default.
• W2105470010 cites W1992551170 @default.
• W2105470010 cites W1993319836 @default.
• W2105470010 cites W1995344823 @default.
• W2105470010 cites W2007082011 @default.
• W2105470010 cites W2007400263 @default.
• W2105470010 cites W2011036671 @default.
• W2105470010 cites W2011522374 @default.
• W2105470010 cites W2018833123 @default.
• W2105470010 cites W2035706761 @default.
• W2105470010 cites W2049952729 @default.
• W2105470010 cites W2055348484 @default.
• W2105470010 cites W2059169426 @default.
• W2105470010 cites W2061864654 @default.
• W2105470010 cites W2063023419 @default.
• W2105470010 cites W2063115905 @default.
• W2105470010 cites W2069837726 @default.
• W2105470010 cites W2071039186 @default.
• W2105470010 cites W2072163641 @default.
• W2105470010 cites W2074551498 @default.
• W2105470010 cites W2076338201 @default.
• W2105470010 cites W2080190286 @default.
• W2105470010 cites W2080964409 @default.
• W2105470010 cites W2083702938 @default.
• W2105470010 cites W2085103446 @default.
• W2105470010 cites W2085208012 @default.
• W2105470010 cites W2085961837 @default.
• W2105470010 cites W2115405905 @default.
• W2105470010 cites W2156009899 @default.
• W2105470010 cites W2157104891 @default.
• W2105470010 cites W2162862570 @default.
• W2105470010 cites W2166244464 @default.
• W2105470010 cites W2401435247 @default.
• W2105470010 cites W2414747719 @default.
• W2105470010 cites W2416680389 @default.
• W2105470010 cites W2422698979 @default.
• W2105470010 cites W2436637113 @default.
• W2105470010 cites W61350937 @default.
• W2105470010 doi "https://doi.org/10.1016/s0531-5565(00)00106-6" @default.
• W2105470010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10978684" @default.
• W2105470010 hasPublicationYear "2000" @default.
• W2105470010 type Work @default.
• W2105470010 sameAs 2105470010 @default.
• W2105470010 citedByCount "54" @default.
• W2105470010 countsByYear W21054700102012 @default.
• W2105470010 countsByYear W21054700102013 @default.
• W2105470010 countsByYear W21054700102014 @default.
• W2105470010 countsByYear W21054700102015 @default.
• W2105470010 countsByYear W21054700102016 @default.
• W2105470010 countsByYear W21054700102018 @default.
• W2105470010 countsByYear W21054700102019 @default.
• W2105470010 countsByYear W21054700102021 @default.
• W2105470010 countsByYear W21054700102022 @default.
• W2105470010 countsByYear W21054700102023 @default.
• W2105470010 crossrefType "journal-article" @default.
• W2105470010 hasAuthorship W2105470010A5050117064 @default.
• W2105470010 hasAuthorship W2105470010A5083640496 @default.
• W2105470010 hasConcept C150903083 @default.
• W2105470010 hasConcept C154317977 @default.
• W2105470010 hasConcept C202751555 @default.
• W2105470010 hasConcept C203014093 @default.
• W2105470010 hasConcept C207001950 @default.
• W2105470010 hasConcept C2778102761 @default.
• W2105470010 hasConcept C2778690821 @default.
• W2105470010 hasConcept C2780007613 @default.
• W2105470010 hasConcept C2780931953 @default.
• W2105470010 hasConcept C55493867 @default.
• W2105470010 hasConcept C86803240 @default.
• W2105470010 hasConceptScore W2105470010C150903083 @default.
• W2105470010 hasConceptScore W2105470010C154317977 @default.
• W2105470010 hasConceptScore W2105470010C202751555 @default.
• W2105470010 hasConceptScore W2105470010C203014093 @default.
• W2105470010 hasConceptScore W2105470010C207001950 @default.
• W2105470010 hasConceptScore W2105470010C2778102761 @default.
• W2105470010 hasConceptScore W2105470010C2778690821 @default.
• W2105470010 hasConceptScore W2105470010C2780007613 @default.
• W2105470010 hasConceptScore W2105470010C2780931953 @default.
• W2105470010 hasConceptScore W2105470010C55493867 @default.

• next