Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105477344> ?p ?o ?g. }
- W2105477344 endingPage "41" @default.
- W2105477344 startingPage "33" @default.
- W2105477344 abstract "Aberrant regulation of T helper (Th) cell maturation is associated with a number of autoimmune conditions, including allergic disorders and rheumatoid arthritis. The Src homology domain protein B (Shb) adaptor protein was recently implicated as a regulator of Th cell differentiation. Shb is an integral component of the T-cell receptor (TCR) signalling complex and in the absence of Shb the TCR is less responsive to stimulation, resulting in the preferential development of Th2 responses under conditions of in vitro stimulation. In the present study, we extend those observations to an in vivo situation using a murine model of atopic dermatitis. Shb knockout mice develop more pronounced symptoms of atopic dermatitis with increased localized oedema, epidermal hyperplasia and IgE production. Dermal infiltration of mast cells, eosinophils, CD4(+) Th cells and F4/80(+) macrophages was also significantly increased in Shb-deficient mice. This correlated with elevated transcription of the hallmark Th2 cytokines interleukin-4 and interleukin-5. The loss of Shb therefore alters TCR signalling ability, thereby favouring the development of Th2-driven inflammation and exacerbating symptoms of allergy." @default.
- W2105477344 created "2016-06-24" @default.
- W2105477344 creator A5002897182 @default.
- W2105477344 creator A5026393119 @default.
- W2105477344 creator A5053898303 @default.
- W2105477344 date "2014-07-29" @default.
- W2105477344 modified "2023-10-02" @default.
- W2105477344 title "Absence of the adaptor protein Shb potentiates the T helper type 2 response in a mouse model of atopic dermatitis" @default.
- W2105477344 cites W1484685014 @default.
- W2105477344 cites W1506430118 @default.
- W2105477344 cites W1538862662 @default.
- W2105477344 cites W1539987334 @default.
- W2105477344 cites W1568886603 @default.
- W2105477344 cites W1600662889 @default.
- W2105477344 cites W1616490052 @default.
- W2105477344 cites W1630060072 @default.
- W2105477344 cites W1650320961 @default.
- W2105477344 cites W1780419005 @default.
- W2105477344 cites W1823764983 @default.
- W2105477344 cites W1844591653 @default.
- W2105477344 cites W1942668068 @default.
- W2105477344 cites W1950561235 @default.
- W2105477344 cites W1950717981 @default.
- W2105477344 cites W1964102602 @default.
- W2105477344 cites W1975438745 @default.
- W2105477344 cites W1977674120 @default.
- W2105477344 cites W1986430818 @default.
- W2105477344 cites W1997856674 @default.
- W2105477344 cites W2006612668 @default.
- W2105477344 cites W2018379768 @default.
- W2105477344 cites W2022689552 @default.
- W2105477344 cites W2025961918 @default.
- W2105477344 cites W2026990074 @default.
- W2105477344 cites W2027633599 @default.
- W2105477344 cites W2029104932 @default.
- W2105477344 cites W2033996550 @default.
- W2105477344 cites W2038011147 @default.
- W2105477344 cites W2039253450 @default.
- W2105477344 cites W2039627333 @default.
- W2105477344 cites W2040582412 @default.
- W2105477344 cites W2042616736 @default.
- W2105477344 cites W2045199547 @default.
- W2105477344 cites W2046318425 @default.
- W2105477344 cites W2052421048 @default.
- W2105477344 cites W2056859114 @default.
- W2105477344 cites W2058211118 @default.
- W2105477344 cites W2059287438 @default.
- W2105477344 cites W2059942477 @default.
- W2105477344 cites W2064548895 @default.
- W2105477344 cites W2065871536 @default.
- W2105477344 cites W2066750311 @default.
- W2105477344 cites W2067049479 @default.
- W2105477344 cites W2067867776 @default.
- W2105477344 cites W2069808501 @default.
- W2105477344 cites W2071019594 @default.
- W2105477344 cites W2072490043 @default.
- W2105477344 cites W2073063423 @default.
- W2105477344 cites W2073476576 @default.
- W2105477344 cites W2077865652 @default.
- W2105477344 cites W2081595143 @default.
- W2105477344 cites W2089961321 @default.
- W2105477344 cites W2090003699 @default.
- W2105477344 cites W2091789739 @default.
- W2105477344 cites W2095687823 @default.
- W2105477344 cites W2096279219 @default.
- W2105477344 cites W2100683309 @default.
- W2105477344 cites W2105130062 @default.
- W2105477344 cites W2107235439 @default.
- W2105477344 cites W2108996243 @default.
- W2105477344 cites W2110421291 @default.
- W2105477344 cites W2117340681 @default.
- W2105477344 cites W2122939321 @default.
- W2105477344 cites W2128181270 @default.
- W2105477344 cites W2135073831 @default.
- W2105477344 cites W2139144899 @default.
- W2105477344 cites W2140686309 @default.
- W2105477344 cites W2141895910 @default.
- W2105477344 cites W2160985360 @default.
- W2105477344 cites W2160989271 @default.
- W2105477344 cites W2162803006 @default.
- W2105477344 cites W2165933222 @default.
- W2105477344 cites W2170948066 @default.
- W2105477344 cites W2312870247 @default.
- W2105477344 cites W2315018741 @default.
- W2105477344 cites W2462838772 @default.
- W2105477344 cites W4313324526 @default.
- W2105477344 cites W4313335067 @default.
- W2105477344 doi "https://doi.org/10.1111/imm.12286" @default.
- W2105477344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4137953" @default.
- W2105477344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24645804" @default.
- W2105477344 hasPublicationYear "2014" @default.
- W2105477344 type Work @default.
- W2105477344 sameAs 2105477344 @default.
- W2105477344 citedByCount "12" @default.
- W2105477344 countsByYear W21054773442015 @default.
- W2105477344 countsByYear W21054773442016 @default.
- W2105477344 countsByYear W21054773442017 @default.
- W2105477344 countsByYear W21054773442018 @default.