FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105478531> ?p ?o ?g. }

• W2105478531 endingPage "1858" @default.
• W2105478531 startingPage "1845" @default.
• W2105478531 abstract "Gcs1 is an Arf GTPase-activating protein (Arf-GAP) that mediates Golgi-ER and post-Golgi vesicle transport in yeast. Here we show that the Snc1,2 v-SNAREs, which mediate endocytosis and exocytosis, interact physically and genetically with Gcs1. Moreover, Gcs1 and the Snc v-SNAREs colocalize to subcellular structures that correspond to the trans-Golgi and endosomal compartments. Studies performed in vitro demonstrate that the Snc-Gcs1 interaction results in the efficient binding of recombinant Arf1Delta17N-Q71L to the v-SNARE and the recruitment of purified coatomer. In contrast, the presence of Snc had no effect on Gcs1 Arf-GAP activity in vitro, suggesting that v-SNARE binding does not attenuate Arf1 function. Disruption of both the SNC and GCS1 genes results in synthetic lethality, whereas overexpression of either SNC gene inhibits the growth of a distinct subset of COPI mutants. We show that GFP-Snc1 recycling to the trans-Golgi is impaired in gcs1Delta cells and these COPI mutants. Together, these results suggest that Gcs1 facilitates the incorporation of the Snc v-SNAREs into COPI recycling vesicles and subsequent endosome-Golgi sorting in yeast." @default.
• W2105478531 created "2016-06-24" @default.
• W2105478531 creator A5009519086 @default.
• W2105478531 creator A5021075992 @default.
• W2105478531 creator A5035327789 @default.
• W2105478531 creator A5038099252 @default.
• W2105478531 creator A5050792783 @default.
• W2105478531 creator A5064480158 @default.
• W2105478531 creator A5069272617 @default.
• W2105478531 creator A5078652046 @default.
• W2105478531 creator A5086235867 @default.
• W2105478531 creator A5088563796 @default.
• W2105478531 date "2006-04-01" @default.
• W2105478531 modified "2023-10-15" @default.
• W2105478531 title "The Gcs1 Arf-GAP Mediates Snc1,2 v-SNARE Retrieval to the Golgi in Yeast" @default.
• W2105478531 cites W1485982200 @default.
• W2105478531 cites W1491787713 @default.
• W2105478531 cites W1498791588 @default.
• W2105478531 cites W1520187505 @default.
• W2105478531 cites W1608351694 @default.
• W2105478531 cites W1962198873 @default.
• W2105478531 cites W1964660197 @default.
• W2105478531 cites W1968842619 @default.
• W2105478531 cites W1973749261 @default.
• W2105478531 cites W1988752034 @default.
• W2105478531 cites W1990349821 @default.
• W2105478531 cites W1994528127 @default.
• W2105478531 cites W1996868880 @default.
• W2105478531 cites W1997859335 @default.
• W2105478531 cites W2006446212 @default.
• W2105478531 cites W2012436969 @default.
• W2105478531 cites W2012500168 @default.
• W2105478531 cites W2013673237 @default.
• W2105478531 cites W2033053971 @default.
• W2105478531 cites W2033895304 @default.
• W2105478531 cites W2035807916 @default.
• W2105478531 cites W2036117327 @default.
• W2105478531 cites W2040169742 @default.
• W2105478531 cites W2044137708 @default.
• W2105478531 cites W2047808133 @default.
• W2105478531 cites W2052887360 @default.
• W2105478531 cites W2055614585 @default.
• W2105478531 cites W2057703601 @default.
• W2105478531 cites W2059468091 @default.
• W2105478531 cites W2075631488 @default.
• W2105478531 cites W2077416083 @default.
• W2105478531 cites W2078338501 @default.
• W2105478531 cites W2078802378 @default.
• W2105478531 cites W2081151685 @default.
• W2105478531 cites W2082313976 @default.
• W2105478531 cites W2085231991 @default.
• W2105478531 cites W2086907495 @default.
• W2105478531 cites W2090549652 @default.
• W2105478531 cites W2094001022 @default.
• W2105478531 cites W2094888005 @default.
• W2105478531 cites W2095999600 @default.
• W2105478531 cites W2104969300 @default.
• W2105478531 cites W2108277395 @default.
• W2105478531 cites W2109672926 @default.
• W2105478531 cites W2111055318 @default.
• W2105478531 cites W2112488154 @default.
• W2105478531 cites W2114736119 @default.
• W2105478531 cites W2118515161 @default.
• W2105478531 cites W2120193545 @default.
• W2105478531 cites W2126138447 @default.
• W2105478531 cites W2127073167 @default.
• W2105478531 cites W2130892618 @default.
• W2105478531 cites W2132497596 @default.
• W2105478531 cites W2137943169 @default.
• W2105478531 cites W2142946131 @default.
• W2105478531 cites W2145530482 @default.
• W2105478531 cites W2152719012 @default.
• W2105478531 cites W2158249700 @default.
• W2105478531 cites W2159257811 @default.
• W2105478531 cites W2160513335 @default.
• W2105478531 cites W2162261737 @default.
• W2105478531 cites W2164785771 @default.
• W2105478531 cites W2167869241 @default.
• W2105478531 cites W2169655990 @default.
• W2105478531 cites W2171495269 @default.
• W2105478531 cites W2171810148 @default.
• W2105478531 cites W2179777589 @default.
• W2105478531 cites W2181827540 @default.
• W2105478531 cites W4293760936 @default.
• W2105478531 doi "https://doi.org/10.1091/mbc.e05-09-0832" @default.
• W2105478531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1415299" @default.
• W2105478531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16452633" @default.
• W2105478531 hasPublicationYear "2006" @default.
• W2105478531 type Work @default.
• W2105478531 sameAs 2105478531 @default.
• W2105478531 citedByCount "76" @default.
• W2105478531 countsByYear W21054785312012 @default.
• W2105478531 countsByYear W21054785312013 @default.
• W2105478531 countsByYear W21054785312015 @default.
• W2105478531 countsByYear W21054785312016 @default.
• W2105478531 countsByYear W21054785312017 @default.
• W2105478531 countsByYear W21054785312018 @default.
• W2105478531 countsByYear W21054785312019 @default.

• next