Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105487207> ?p ?o ?g. }
- W2105487207 endingPage "1010" @default.
- W2105487207 startingPage "971" @default.
- W2105487207 abstract "At present, diabetic kidney disease affects about 15–25% of type 1 and 30–40% of type 2 diabetic patients. Several decades of extensive research has elucidated various pathways to be implicated in the development of diabetic kidney disease. This review focuses on the metabolic factors beyond blood glucose that are involved in the pathogenesis of diabetic kidney disease, i.e., advanced glycation end-products and the aldose reductase system. Furthermore, the contribution of hemodynamic factors, the renin-angiotensin system, the endothelin system, and the nitric oxide system, as well as the prominent role of the intracellular signaling molecule protein kinase C are discussed. Finally, the respective roles of TGF-β, GH and IGFs, vascular endothelial growth factor, and platelet-derived growth factor are covered. The complex interplay between these different pathways will be highlighted. A brief introduction to each system and description of its expression in the normal kidney is followed by in vitro, experimental, and clinical evidence addressing the role of the system in diabetic kidney disease. Finally, well-known and potential therapeutic strategies targeting each system are discussed, ending with an overall conclusion." @default.
- W2105487207 created "2016-06-24" @default.
- W2105487207 creator A5019721633 @default.
- W2105487207 creator A5029397568 @default.
- W2105487207 creator A5041201756 @default.
- W2105487207 date "2004-12-01" @default.
- W2105487207 modified "2023-10-17" @default.
- W2105487207 title "From Hyperglycemia to Diabetic Kidney Disease: The Role of Metabolic, Hemodynamic, Intracellular Factors and Growth Factors/Cytokines" @default.
- W2105487207 cites W106337374 @default.
- W2105487207 cites W137296389 @default.
- W2105487207 cites W1481324852 @default.
- W2105487207 cites W1488325482 @default.
- W2105487207 cites W1494055834 @default.
- W2105487207 cites W1512879776 @default.
- W2105487207 cites W1527502821 @default.
- W2105487207 cites W1573000660 @default.
- W2105487207 cites W1825417295 @default.
- W2105487207 cites W1837586904 @default.
- W2105487207 cites W1927620573 @default.
- W2105487207 cites W1932654578 @default.
- W2105487207 cites W1964033455 @default.
- W2105487207 cites W1964094408 @default.
- W2105487207 cites W1964290300 @default.
- W2105487207 cites W1964628601 @default.
- W2105487207 cites W1964920299 @default.
- W2105487207 cites W1965374413 @default.
- W2105487207 cites W1965386842 @default.
- W2105487207 cites W1965787101 @default.
- W2105487207 cites W1966346645 @default.
- W2105487207 cites W1966419887 @default.
- W2105487207 cites W1966765513 @default.
- W2105487207 cites W1967620363 @default.
- W2105487207 cites W1967753130 @default.
- W2105487207 cites W1968321101 @default.
- W2105487207 cites W1968428287 @default.
- W2105487207 cites W1969208588 @default.
- W2105487207 cites W1970466613 @default.
- W2105487207 cites W1971713336 @default.
- W2105487207 cites W1971823155 @default.
- W2105487207 cites W1972243263 @default.
- W2105487207 cites W1972509561 @default.
- W2105487207 cites W1972704071 @default.
- W2105487207 cites W1974466887 @default.
- W2105487207 cites W1974502173 @default.
- W2105487207 cites W1974659616 @default.
- W2105487207 cites W1974701636 @default.
- W2105487207 cites W1974703235 @default.
- W2105487207 cites W1975861856 @default.
- W2105487207 cites W1975995627 @default.
- W2105487207 cites W1976041714 @default.
- W2105487207 cites W1976067677 @default.
- W2105487207 cites W1976629461 @default.
- W2105487207 cites W1976802119 @default.
- W2105487207 cites W1976870699 @default.
- W2105487207 cites W1977642064 @default.
- W2105487207 cites W1978943685 @default.
- W2105487207 cites W1979228623 @default.
- W2105487207 cites W1979334302 @default.
- W2105487207 cites W1980097141 @default.
- W2105487207 cites W1980643281 @default.
- W2105487207 cites W1980960629 @default.
- W2105487207 cites W1981606978 @default.
- W2105487207 cites W1982012356 @default.
- W2105487207 cites W1982205510 @default.
- W2105487207 cites W1982679003 @default.
- W2105487207 cites W1983359799 @default.
- W2105487207 cites W1984261234 @default.
- W2105487207 cites W1984659199 @default.
- W2105487207 cites W1985990986 @default.
- W2105487207 cites W1986495348 @default.
- W2105487207 cites W1987298734 @default.
- W2105487207 cites W1987514640 @default.
- W2105487207 cites W1990640296 @default.
- W2105487207 cites W1990649196 @default.
- W2105487207 cites W1990806982 @default.
- W2105487207 cites W1991088354 @default.
- W2105487207 cites W1991525399 @default.
- W2105487207 cites W1993905392 @default.
- W2105487207 cites W1994732907 @default.
- W2105487207 cites W1995428435 @default.
- W2105487207 cites W1996149627 @default.
- W2105487207 cites W1996424575 @default.
- W2105487207 cites W1997676435 @default.
- W2105487207 cites W1999218740 @default.
- W2105487207 cites W2000288269 @default.
- W2105487207 cites W2000519471 @default.
- W2105487207 cites W2000881220 @default.
- W2105487207 cites W2001064530 @default.
- W2105487207 cites W2001109862 @default.
- W2105487207 cites W2002661436 @default.
- W2105487207 cites W2004002385 @default.
- W2105487207 cites W2004134871 @default.
- W2105487207 cites W2004231827 @default.
- W2105487207 cites W2004695078 @default.
- W2105487207 cites W2005482739 @default.
- W2105487207 cites W2007616702 @default.
- W2105487207 cites W2007643806 @default.
- W2105487207 cites W2007880055 @default.