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• W2105487263 abstract "Prone positioning has been used for many years in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), with no clear benefit for patient outcome. Meta-analyses have suggested better survival in patients with an arterial oxygen tension (<i>P</i>_aO₂)/inspiratory oxygen fraction (<i>F</i>_IO₂) ratio <100 mmHg. A recent randomised controlled trial was performed in ARDS patients after a 12–24 h stabilisation period and severity criteria (<i>P</i>_aO₂/<i>F</i>_IO₂ <150 mmHg at a positive end-expiratory pressure ≥5 cmH₂O). This trial has demonstrated a significant reduction in mortality from 32.8% in the supine group to 16% in the prone group (p<0.001). The reasons for this dramatic effect are not clear but probably involves a reduction in ventilator-induced lung injury due to prone positioning, for which there is ample evidence in experimental and clinical studies. The aims of this article are to discuss: the rationale of prone positioning in patients with ALI/ARDS; the evidence of its use based on trial analysis; and the limitations of its use as well as the current place of prone positioning in the management of patients with ALI/ARDS. From the currently available data, prone positioning should be used as a first-line therapy in patients with severe ALI/ARDS." @default.
• W2105487263 created "2016-06-24" @default.
• W2105487263 creator A5068990803 @default.
• W2105487263 date "2014-05-31" @default.
• W2105487263 modified "2023-10-18" @default.
• W2105487263 title "Prone ventilation in acute respiratory distress syndrome" @default.
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• W2105487263 doi "https://doi.org/10.1183/09059180.00001114" @default.
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