FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105489768> ?p ?o ?g. }

• W2105489768 endingPage "4447" @default.
• W2105489768 startingPage "4441" @default.
• W2105489768 abstract "A coma is a serious complication, which can occur following traumatic brain injury (TBI), for which no effective treatment has been established. Previous studies have suggested that neural electrical stimulation, including median nerve stimulation (MNS), may be an effective method for treating patients in a coma, and orexin‑A, an excitatory hypothalamic neuropeptide, may be involved in wakefulness. However, the exact mechanisms underlying this involvement remain to be elucidated. The present study aimed to examine the arousal‑promoting role of MNS in rats in a TBI‑induced coma and to investigate the potential mechanisms involved. A total of 90 rats were divided into three groups, comprising a control group, sham‑stimulated (TBI) group and a stimulated (TBI + MNS) group. MNS was performed on the animals, which were in a TBI‑induced comatose state. Changes in the behavior of the rats were observed following MNS. Subsequently, hypothalamic tissues were extracted from the rats 6, 12 and 24 h following TBI or MNS, respectively. The expression levels of orexin‑A and orexin receptor‑1 (OX1R) in the hypothalamus were examined using immunohistochemistry, western blotting and an enzyme‑linked immunosorbent assay. The results demonstrated that 21 rats subjected to TBI‑induced coma exhibited a restored righting reflex and response to pain stimuli following MNS. In addition, ignificant differences in the expression levels of orexin‑A and OXIR were observed among the three groups and among the time‑points. Orexin‑A and OX1R were upregulated following MNS. The rats in the stimulated group reacted to the MNS and exhibited a re‑awakening response. The results of the present study indicated that MNS may be a therapeutic option for TBI‑induced coma. The mechanism may be associated with increasing expression levels of the excitatory hypothalamic neuropeptide, orexin-A, and its receptor, OX1R, in the hypothalamic region." @default.
• W2105489768 created "2016-06-24" @default.
• W2105489768 creator A5042771313 @default.
• W2105489768 creator A5077241051 @default.
• W2105489768 creator A5086664647 @default.
• W2105489768 creator A5091324668 @default.
• W2105489768 date "2015-06-08" @default.
• W2105489768 modified "2023-10-15" @default.
• W2105489768 title "Wake-promoting actions of median nerve stimulation in TBI-induced coma: An investigation of orexin-A and orexin receptor 1 in the hypothalamic region" @default.
• W2105489768 cites W1627229807 @default.
• W2105489768 cites W1698695320 @default.
• W2105489768 cites W1758383936 @default.
• W2105489768 cites W1788923353 @default.
• W2105489768 cites W1985965113 @default.
• W2105489768 cites W1986056552 @default.
• W2105489768 cites W1996614758 @default.
• W2105489768 cites W1999768197 @default.
• W2105489768 cites W2011023895 @default.
• W2105489768 cites W2015484182 @default.
• W2105489768 cites W2019476872 @default.
• W2105489768 cites W2027740042 @default.
• W2105489768 cites W2031458630 @default.
• W2105489768 cites W2036711071 @default.
• W2105489768 cites W2036933770 @default.
• W2105489768 cites W2044246448 @default.
• W2105489768 cites W2055154971 @default.
• W2105489768 cites W2064442671 @default.
• W2105489768 cites W2067851639 @default.
• W2105489768 cites W2089598994 @default.
• W2105489768 cites W2105217252 @default.
• W2105489768 cites W2143609607 @default.
• W2105489768 cites W2144249632 @default.
• W2105489768 cites W2146382418 @default.
• W2105489768 cites W2147313988 @default.
• W2105489768 cites W2154041886 @default.
• W2105489768 cites W2161326986 @default.
• W2105489768 cites W2163162884 @default.
• W2105489768 cites W2164675383 @default.
• W2105489768 cites W3122228325 @default.
• W2105489768 doi "https://doi.org/10.3892/mmr.2015.3898" @default.
• W2105489768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26059340" @default.
• W2105489768 hasPublicationYear "2015" @default.
• W2105489768 type Work @default.
• W2105489768 sameAs 2105489768 @default.
• W2105489768 citedByCount "15" @default.
• W2105489768 countsByYear W21054897682016 @default.
• W2105489768 countsByYear W21054897682018 @default.
• W2105489768 countsByYear W21054897682019 @default.
• W2105489768 countsByYear W21054897682021 @default.
• W2105489768 countsByYear W21054897682022 @default.
• W2105489768 countsByYear W21054897682023 @default.
• W2105489768 crossrefType "journal-article" @default.
• W2105489768 hasAuthorship W2105489768A5042771313 @default.
• W2105489768 hasAuthorship W2105489768A5077241051 @default.
• W2105489768 hasAuthorship W2105489768A5086664647 @default.
• W2105489768 hasAuthorship W2105489768A5091324668 @default.
• W2105489768 hasBestOaLocation W21054897681 @default.
• W2105489768 hasConcept C100136789 @default.
• W2105489768 hasConcept C118303440 @default.
• W2105489768 hasConcept C118552586 @default.
• W2105489768 hasConcept C120665830 @default.
• W2105489768 hasConcept C121332964 @default.
• W2105489768 hasConcept C126322002 @default.
• W2105489768 hasConcept C134018914 @default.
• W2105489768 hasConcept C170493617 @default.
• W2105489768 hasConcept C24998067 @default.
• W2105489768 hasConcept C2776119998 @default.
• W2105489768 hasConcept C2777003273 @default.
• W2105489768 hasConcept C2779320081 @default.
• W2105489768 hasConcept C2779605129 @default.
• W2105489768 hasConcept C2779680196 @default.
• W2105489768 hasConcept C2781017439 @default.
• W2105489768 hasConcept C42219234 @default.
• W2105489768 hasConcept C522805319 @default.
• W2105489768 hasConcept C71924100 @default.
• W2105489768 hasConceptScore W2105489768C100136789 @default.
• W2105489768 hasConceptScore W2105489768C118303440 @default.
• W2105489768 hasConceptScore W2105489768C118552586 @default.
• W2105489768 hasConceptScore W2105489768C120665830 @default.
• W2105489768 hasConceptScore W2105489768C121332964 @default.
• W2105489768 hasConceptScore W2105489768C126322002 @default.
• W2105489768 hasConceptScore W2105489768C134018914 @default.
• W2105489768 hasConceptScore W2105489768C170493617 @default.
• W2105489768 hasConceptScore W2105489768C24998067 @default.
• W2105489768 hasConceptScore W2105489768C2776119998 @default.
• W2105489768 hasConceptScore W2105489768C2777003273 @default.
• W2105489768 hasConceptScore W2105489768C2779320081 @default.
• W2105489768 hasConceptScore W2105489768C2779605129 @default.
• W2105489768 hasConceptScore W2105489768C2779680196 @default.
• W2105489768 hasConceptScore W2105489768C2781017439 @default.
• W2105489768 hasConceptScore W2105489768C42219234 @default.
• W2105489768 hasConceptScore W2105489768C522805319 @default.
• W2105489768 hasConceptScore W2105489768C71924100 @default.
• W2105489768 hasIssue "3" @default.
• W2105489768 hasLocation W21054897681 @default.
• W2105489768 hasLocation W21054897682 @default.
• W2105489768 hasOpenAccess W2105489768 @default.
• W2105489768 hasPrimaryLocation W21054897681 @default.

• next