FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105497522> ?p ?o ?g. }

• W2105497522 endingPage "11" @default.
• W2105497522 startingPage "3" @default.
• W2105497522 abstract "There is a complex, bidirectional interdependence between sex steroid hormones and epilepsy; hormones affect seizures, while seizures affect hormones thereby disturbing reproductive endocrine function. Both female and male sex steroid hormones influence brain excitability. For the female sex steroid hormones, progesterone and its metabolites are anticonvulsant, while estrogens are mainly proconvulsant. The monthly fluctuations in hormone levels of estrogen and progesterone are the basis for catamenial epilepsy described elsewhere in this issue. Androgens are mainly anticonvulsant, but the effects are more varied, probably because of its metabolism to, among others, estradiol. The mechanisms for the effects of sex steroid hormones on brain excitability are related to both classical, intracellularly mediated effects, and non-classical membrane effects due to binding to membrane receptors. The latter are considered the most important in relation to epilepsy. The different sex steroids can also be further metabolized within the brain to different neurosteroids, which are even more potent with regard to their effect on excitability. Estrogens potentiate glutamate responses, primarily by potentiating NMDA receptor activity, but also by affecting GABA-ergic mechanisms and altering brain morphology by increasing dendritic spine density. Progesterone and its main metabolite 5α-pregnan-3α-ol-20-one (3α-5α-THP) act mainly to enhance postsynaptic GABA-ergic activity, while androgens enhance GABA-activated currents. Seizures and epileptic discharges also affect sex steroid hormones. There are close anatomical connections between the temporolimbic system and the hypothalamus controlling the endocrine system. Several studies have shown that epileptic activity, especially mediated through the amygdala, alters reproductive function, including reduced ovarian cyclicity in females and altered sex steroid hormone levels in both genders. Furthermore, there is an asymmetric activation of the hypothalamus with unilateral amygdala seizures. This may, again, be the basis for the occurrence of different reproductive endocrine disorders described for patients with left-sided or right-sided temporal lobe epilepsy." @default.
• W2105497522 created "2016-06-24" @default.
• W2105497522 creator A5051321266 @default.
• W2105497522 creator A5051634049 @default.
• W2105497522 creator A5084316971 @default.
• W2105497522 date "2015-05-01" @default.
• W2105497522 modified "2023-10-14" @default.
• W2105497522 title "Interactions between hormones and epilepsy" @default.
• W2105497522 cites W119108515 @default.
• W2105497522 cites W1647312149 @default.
• W2105497522 cites W1771372085 @default.
• W2105497522 cites W1939084108 @default.
• W2105497522 cites W1967330359 @default.
• W2105497522 cites W1972888313 @default.
• W2105497522 cites W1974045635 @default.
• W2105497522 cites W1982210326 @default.
• W2105497522 cites W1982627216 @default.
• W2105497522 cites W1983056871 @default.
• W2105497522 cites W1984191986 @default.
• W2105497522 cites W1993212191 @default.
• W2105497522 cites W1996719603 @default.
• W2105497522 cites W1998765262 @default.
• W2105497522 cites W2003902982 @default.
• W2105497522 cites W2009410204 @default.
• W2105497522 cites W2013025245 @default.
• W2105497522 cites W2014945515 @default.
• W2105497522 cites W2015040556 @default.
• W2105497522 cites W2019173227 @default.
• W2105497522 cites W2020886601 @default.
• W2105497522 cites W2021802578 @default.
• W2105497522 cites W2023021541 @default.
• W2105497522 cites W2023383100 @default.
• W2105497522 cites W2023402273 @default.
• W2105497522 cites W2023669821 @default.
• W2105497522 cites W2026110821 @default.
• W2105497522 cites W2026681272 @default.
• W2105497522 cites W2027150573 @default.
• W2105497522 cites W2027470383 @default.
• W2105497522 cites W2030462051 @default.
• W2105497522 cites W2032201176 @default.
• W2105497522 cites W2032506233 @default.
• W2105497522 cites W2037613786 @default.
• W2105497522 cites W2038687397 @default.
• W2105497522 cites W2039426250 @default.
• W2105497522 cites W2048254811 @default.
• W2105497522 cites W2051024082 @default.
• W2105497522 cites W2053141298 @default.
• W2105497522 cites W2055656115 @default.
• W2105497522 cites W2061012355 @default.
• W2105497522 cites W2061554393 @default.
• W2105497522 cites W2064785273 @default.
• W2105497522 cites W2066907188 @default.
• W2105497522 cites W2069438724 @default.
• W2105497522 cites W2070294313 @default.
• W2105497522 cites W2071766727 @default.
• W2105497522 cites W2074924866 @default.
• W2105497522 cites W2078365959 @default.
• W2105497522 cites W2079769181 @default.
• W2105497522 cites W2083418663 @default.
• W2105497522 cites W2083447043 @default.
• W2105497522 cites W2084633620 @default.
• W2105497522 cites W2089098683 @default.
• W2105497522 cites W2100984980 @default.
• W2105497522 cites W2103454769 @default.
• W2105497522 cites W2110887671 @default.
• W2105497522 cites W2116942680 @default.
• W2105497522 cites W2119261700 @default.
• W2105497522 cites W2121403142 @default.
• W2105497522 cites W2123228975 @default.
• W2105497522 cites W2138341890 @default.
• W2105497522 cites W2144872567 @default.
• W2105497522 cites W2148176139 @default.
• W2105497522 cites W2148412570 @default.
• W2105497522 cites W2163041255 @default.
• W2105497522 cites W2166993454 @default.
• W2105497522 cites W2167766704 @default.
• W2105497522 cites W2301339089 @default.
• W2105497522 cites W2316154595 @default.
• W2105497522 cites W2412219500 @default.
• W2105497522 cites W4233635697 @default.
• W2105497522 cites W4251533758 @default.
• W2105497522 doi "https://doi.org/10.1016/j.seizure.2015.02.012" @default.
• W2105497522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25765693" @default.
• W2105497522 hasPublicationYear "2015" @default.
• W2105497522 type Work @default.
• W2105497522 sameAs 2105497522 @default.
• W2105497522 citedByCount "91" @default.
• W2105497522 countsByYear W21054975222015 @default.
• W2105497522 countsByYear W21054975222016 @default.
• W2105497522 countsByYear W21054975222017 @default.
• W2105497522 countsByYear W21054975222018 @default.
• W2105497522 countsByYear W21054975222019 @default.
• W2105497522 countsByYear W21054975222020 @default.
• W2105497522 countsByYear W21054975222021 @default.
• W2105497522 countsByYear W21054975222022 @default.
• W2105497522 countsByYear W21054975222023 @default.
• W2105497522 crossrefType "journal-article" @default.
• W2105497522 hasAuthorship W2105497522A5051321266 @default.

• next