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- W2105500522 abstract "Since their discovery in 1975, monoclonal antibodies have been at the forefront of modern medicine. These monospecific immune proteins target a single antigen. But at the same time that monoclonal antibodies have hogged the spotlight, their distant cousins, bispecific antibodies, have been floating around.First proposed in 1960, such a protein would be able to target 2 different antigens, or epitopes, on 2 different cells, on the same cell, or even within a single antigen on a single cell. The therapeutic possibilities would be awesome. There was only one catch.“A discrete, directed pairing of two arms to engage two specific antigens is not achieved in nature,” says Christoph Spiess, a scientist in the department of antibody engineering at Genentech Inc, a biotechnology company in San Francisco, CA.In the more than 50 years after the idea was proposed, bispecific research and breakthroughs have taken off (1). Here we consider a recent report on the first-ever creation of bispecific antibodies from any 2 existing antibodies (2). We also look beyond the therapeutic benefits and consider the clinical applications of these 2-pronged proteins.Shaped like a Y, an antibody has a particular molecular structure. It is made up of 4 chains, 2 heavy and 2 light chains. Across antibodies of the same subtype and isotype, the stem of the Y remains constant, explains Spiess. The tips provide the specificity toward an antigen or binding site. This is where the power of bispecific antibodies lies.Christoph SpiessTo create a tip pairing that will bind to either 2 different antigens or 2 different regions on the …" @default.
- W2105500522 created "2016-06-24" @default.
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- W2105500522 date "2014-04-01" @default.
- W2105500522 modified "2023-09-26" @default.
- W2105500522 title "A Two-Pronged Approach" @default.
- W2105500522 cites W1982043116 @default.
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- W2105500522 doi "https://doi.org/10.1373/clinchem.2013.221200" @default.
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