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• W2105509900 abstract "Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N12-formyl derivative of Et 729 and the natural N12-oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-beta-carboline-substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra." @default.
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• W2105509900 date "1992-12-01" @default.
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• W2105509900 title "Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo." @default.
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• W2105509900 doi "https://doi.org/10.1073/pnas.89.23.11456" @default.
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