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• W2105517660 abstract "Abstract Direct costimulation of CD8+ T cells is more important than the canonical licensing of DCs by CD4 help, in influenza. The helper-dependent pathway of priming CD8+ T cells involves “licensing” of DCs by CD40L on CD4+ T cells. The helper-independent (“helpless”) pathways elicited by many viruses, including influenza, are less widely understood. We have postulated that CD40L can be up-regulated on DCs by such viruses, and this promotes priming of CD8+ T cells via CD40. Most studies on costimulation have been performed in the presence of CD4+ T cells, and so the role of CD40L costimulation under helpless circumstances has not been fully elucidated. Here, we investigated such a role for CD40L using CD40L KO mice. Although the number of influenza-specific CD8+ T cells was unaffected by the absence of CD4+ T cells, it was markedly decreased in the absence of CD40L. Proliferation (the number of CD44+BrdU+ influenza-specific CD8+ T cells) in the primary response was diminished in CD40L KO mice at Day 8 but not at Day 5 after infection. MLR studies indicated that CD40L expression on DCs was critical for CD8+ T cell activation. Adoptive transfer of CD40 KO CD8+ T cells compared with WT cells confirmed that CD40 on such cells was critical for the generation of primary anti-influenza CD8+ T cell responses. The late effect also corresponded with the late expression of CD40 by influenza-specific CD8+ T cells. We suggest that costimulation via CD40L on DCs and CD40 on CD8+ T cells is important in optimizing primary CD8+ T cell responses during influenza infection." @default.
• W2105517660 created "2016-06-24" @default.
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• W2105517660 date "2013-01-01" @default.
• W2105517660 modified "2023-09-27" @default.
• W2105517660 title "Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response" @default.
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• W2105517660 doi "https://doi.org/10.1189/jlb.0612266" @default.
• W2105517660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23108101" @default.
• W2105517660 hasPublicationYear "2013" @default.
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