Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105532009> ?p ?o ?g. }
- W2105532009 endingPage "321" @default.
- W2105532009 startingPage "312" @default.
- W2105532009 abstract "Obesity-related diseases now threaten to reach epidemic proportions in the United States. Here we review in a rodent model of genetic obesity, the fa/fa Zucker diabetic fatty (ZDF) rat, the mechanisms involved in the most common complications of diet-induced human obesity, i.e., noninsulin-dependent diabetes mellitus, and myocardial dysfunction. In ZDF rats, hyperphagia leads to hyperinsulinemia, which up-regulates transcription factors that stimulate lipogenesis. This causes ectopic deposition of triacylglycerol in nonadipocytes, providing fatty acid (FA) substrate for damaging pathways of nonoxidative metabolism, such as ceramide synthesis. In beta cells and myocardium, the resulting functional impairment and apoptosis cause diabetes and cardiomyopathy. Interventions that lower ectopic lipid accumulation or block nonoxidative metabolism of FA and ceramide formation completely prevent these complications. Given the evidence for a similar etiology for the complications of human obesity, it would be appropriate to develop strategies to avert the predicted epidemic of lipotoxic disorders." @default.
- W2105532009 created "2016-06-24" @default.
- W2105532009 creator A5034171652 @default.
- W2105532009 creator A5065735316 @default.
- W2105532009 date "2001-01-01" @default.
- W2105532009 modified "2023-10-17" @default.
- W2105532009 title "Diseases of liporegulation: new perspective on obesity and related disorders" @default.
- W2105532009 cites W1492605893 @default.
- W2105532009 cites W1512875938 @default.
- W2105532009 cites W1583148430 @default.
- W2105532009 cites W1603091820 @default.
- W2105532009 cites W1639930240 @default.
- W2105532009 cites W1643947316 @default.
- W2105532009 cites W1749647045 @default.
- W2105532009 cites W1905082515 @default.
- W2105532009 cites W1978125779 @default.
- W2105532009 cites W1979296460 @default.
- W2105532009 cites W1981125603 @default.
- W2105532009 cites W1982647833 @default.
- W2105532009 cites W1992938929 @default.
- W2105532009 cites W1995784606 @default.
- W2105532009 cites W1996483376 @default.
- W2105532009 cites W1996713062 @default.
- W2105532009 cites W2001252698 @default.
- W2105532009 cites W2002711503 @default.
- W2105532009 cites W2003852953 @default.
- W2105532009 cites W2015366001 @default.
- W2105532009 cites W2016298359 @default.
- W2105532009 cites W2017033390 @default.
- W2105532009 cites W2017604923 @default.
- W2105532009 cites W2017729786 @default.
- W2105532009 cites W2019425261 @default.
- W2105532009 cites W2020468088 @default.
- W2105532009 cites W2028782957 @default.
- W2105532009 cites W2029186389 @default.
- W2105532009 cites W2029410945 @default.
- W2105532009 cites W2030610610 @default.
- W2105532009 cites W2033630237 @default.
- W2105532009 cites W2035182977 @default.
- W2105532009 cites W2036344921 @default.
- W2105532009 cites W2038381362 @default.
- W2105532009 cites W2040641918 @default.
- W2105532009 cites W2041872947 @default.
- W2105532009 cites W2043180355 @default.
- W2105532009 cites W2047399305 @default.
- W2105532009 cites W2052414336 @default.
- W2105532009 cites W2053286148 @default.
- W2105532009 cites W2055659620 @default.
- W2105532009 cites W2062075110 @default.
- W2105532009 cites W2064715676 @default.
- W2105532009 cites W2065504943 @default.
- W2105532009 cites W2066283353 @default.
- W2105532009 cites W2067124986 @default.
- W2105532009 cites W2067403420 @default.
- W2105532009 cites W2072031497 @default.
- W2105532009 cites W2072281380 @default.
- W2105532009 cites W2074473663 @default.
- W2105532009 cites W2075318184 @default.
- W2105532009 cites W2078081589 @default.
- W2105532009 cites W2079388247 @default.
- W2105532009 cites W2085390992 @default.
- W2105532009 cites W2085588685 @default.
- W2105532009 cites W2087061260 @default.
- W2105532009 cites W2089235913 @default.
- W2105532009 cites W2091015159 @default.
- W2105532009 cites W2092126340 @default.
- W2105532009 cites W2094219435 @default.
- W2105532009 cites W2105600823 @default.
- W2105532009 cites W2107752044 @default.
- W2105532009 cites W2111445543 @default.
- W2105532009 cites W2115817762 @default.
- W2105532009 cites W2125733587 @default.
- W2105532009 cites W2126317966 @default.
- W2105532009 cites W2128232805 @default.
- W2105532009 cites W2128710157 @default.
- W2105532009 cites W2134297608 @default.
- W2105532009 cites W2140241286 @default.
- W2105532009 cites W2143381593 @default.
- W2105532009 cites W2150009380 @default.
- W2105532009 cites W2151350502 @default.
- W2105532009 cites W2154935464 @default.
- W2105532009 cites W2159220871 @default.
- W2105532009 cites W2166788192 @default.
- W2105532009 cites W2170293889 @default.
- W2105532009 cites W2172692903 @default.
- W2105532009 cites W2407618083 @default.
- W2105532009 cites W4238191426 @default.
- W2105532009 cites W4239315275 @default.
- W2105532009 cites W6154090 @default.
- W2105532009 doi "https://doi.org/10.1096/fj.00-0590" @default.
- W2105532009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11156947" @default.
- W2105532009 hasPublicationYear "2001" @default.
- W2105532009 type Work @default.
- W2105532009 sameAs 2105532009 @default.
- W2105532009 citedByCount "401" @default.
- W2105532009 countsByYear W21055320092012 @default.
- W2105532009 countsByYear W21055320092013 @default.
- W2105532009 countsByYear W21055320092014 @default.