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• W2105553204 abstract "Summary: The anticonvulsant and toxic properties of 4-amino-N-(2,6-dimethylphenyl)benzamide, (ADD 75073), were compared with phenytoin (PHT), phenobarbetal (PB), ethosuximide (ESM), and valproate (VPA). These compounds were evaluated in mice and rats using well-standardized anticonvulsant test procedures. The results indicate that ADD 75073 is a very potent anticonvulsant in the maximal electroshock seizure (MES) model. The compound was effective in nontoxic doses following intraperitoneal (i.p.) administration in mice and oral administration in both mice and rats. In mice, the i.p. administration of ADD 75073 resulted in an ED50 value of 2.6 mg/kg as compared with a value of 9.5 mg/kg for phenytoin (PHT) in the same assay. Compound ADD 75073 was ineffective in nontoxic doses against all other seizure models examined in this study, and thus has a pharmacologic profile similar to that of PHT. RÉSUMÉ Les propriétés anticonvulsivantes et toxiques du 4-amino-N-(2,6-diméthylphényl) benzamide (ADD 75073) ont été compareées avec celles de la phénytoïne, du phénobarbital, de ľéthosuximide et du valproate. Ces composés ont éléévalués chez la souris et chez le rat au moyen des tests classiques ľefficacité anticonvulsivante. Nos résultats indiquent que ADD 75073 est un anticonvulsivant puissant dans le modèle de ľélectrochoc maximal. Le produit s'est révélé efficace à des doses non toxiques après administration intra-peYitoneale (ip) chez la souris, et après administration orale chez la souris et le rat. Chez la souris, ľadministration ip ľ ADD 75073 donne une DE50 de 2.6 mg/kg (à comparer à la valeur de 9.5 mg/kg pour la phénytoïne dans la même expérience). ADD 75073 n'a pas montréľefficacitéà des doses non toxiques dans les autres modèles utilisés dans cette étude, et présente done un profil pharmacologique proche de celui de la phénytoïne. RESUMEN Las propiedades anticonvulsivas y tóxicas de la 4-amino-N-(2,6-dimetil-fenil) benzamina (ADD 75073) han sido comparadas con la fenitoina, el fenobarbital, laetosuximida y el valproato. Estos compuestos han sido evaluados en ratones y ratas utili-zando procedimientos bien estandarizados para probar su capa-cidad anticonvulsiva. Los resultados indican que la ADD 75073 es un anticonvulsive muy potente en el modelo de ataques por electroshock máximo (MES). Este compuesto ha sido eficaz en dosis no tóxicas después de la administración intraperitoneal (ip) en ratones y tras la administración oral en ratones y ratas. En ratones, la administración ip de la ADD 75073, produjó un valor ED50 de 2.6 mg/kg comparado con un valor de 9.5 mg/kg para la fenitoina en el mismo ensayo. El compuesto ADD 75073 ha sido ineficaz en dosis no tóxicas contra todos los otros modelos de ataques utilizados en este estudio y por lo tanto, tiene un perfil farmacológico semenjante al de la fenitoina." @default.
• W2105553204 created "2016-06-24" @default.
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• W2105553204 date "1988-04-01" @default.
• W2105553204 modified "2023-10-17" @default.
• W2105553204 title "Comparative Anticonvulsant Activity and Neurotoxicity of 4-Amino-N-(2,6-dimethylphenyl) benzamide and Prototype Antiepileptic Drugs in Mice and Rats" @default.
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• W2105553204 doi "https://doi.org/10.1111/j.1528-1157.1988.tb04420.x" @default.
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