FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105593208> ?p ?o ?g. }

• W2105593208 endingPage "48" @default.
• W2105593208 startingPage "43" @default.
• W2105593208 abstract "Chronic inflammation has been implicated as a cofactor in the development of several human cancers. Interleukin-1beta is a key pro-inflammatory cytokine. We have previously shown associations between polymorphisms at position -511 and -31 in the promoter of the IL1B gene and risk of non-small cell lung cancer. In this study we investigated the functional role of the -31 T/C SNP in the regulation of the IL1B gene. The -31 T/C polymorphism is located in the core promoter and may affect the binding of transcription factors and thereby promoter activity. We therefore established a promoter reporter assay to explore the impact of the promoter variants on the expression of the gene. In the present study, we show that expression from the T-variant of the promoter was higher (p<0.001) than from the C-variant, in A549 cells. Electrophoretic mobility shift assays revealed differential binding of proteins to a promoter fragment containing the SNP. Interestingly, a highly specific complex formed on the C-variant that was not present on the T-variant. Supershift experiments implicated binding of both the CCAAT-enhancer binding protein beta (C/EBPbeta, also called NF-IL6) transcription factor and the TATA-box binding protein (TBP) to the SNP region. Due to the high frequency of this SNP, differences in IL1B gene expression caused by the variants may have significant biological impact in the population." @default.
• W2105593208 created "2016-06-24" @default.
• W2105593208 creator A5004069621 @default.
• W2105593208 creator A5004821647 @default.
• W2105593208 creator A5045259667 @default.
• W2105593208 date "2007-04-01" @default.
• W2105593208 modified "2023-09-26" @default.
• W2105593208 title "Differential binding of proteins to the IL1B −31 T/C polymorphism in lung epithelial cells" @default.
• W2105593208 cites W1500318376 @default.
• W2105593208 cites W1515994079 @default.
• W2105593208 cites W1527817144 @default.
• W2105593208 cites W1884135206 @default.
• W2105593208 cites W1904705252 @default.
• W2105593208 cites W1964787455 @default.
• W2105593208 cites W1965037168 @default.
• W2105593208 cites W1978060183 @default.
• W2105593208 cites W1984843367 @default.
• W2105593208 cites W1992945893 @default.
• W2105593208 cites W2008164620 @default.
• W2105593208 cites W2012027627 @default.
• W2105593208 cites W2021183792 @default.
• W2105593208 cites W2033937708 @default.
• W2105593208 cites W2048167827 @default.
• W2105593208 cites W2049102122 @default.
• W2105593208 cites W2053945436 @default.
• W2105593208 cites W2056161765 @default.
• W2105593208 cites W2061063416 @default.
• W2105593208 cites W2078109078 @default.
• W2105593208 cites W2090032837 @default.
• W2105593208 cites W2105327039 @default.
• W2105593208 cites W2107773056 @default.
• W2105593208 cites W2112271924 @default.
• W2105593208 cites W2116917349 @default.
• W2105593208 cites W2118636735 @default.
• W2105593208 cites W2121470173 @default.
• W2105593208 cites W2127974676 @default.
• W2105593208 cites W2128380182 @default.
• W2105593208 cites W2153550523 @default.
• W2105593208 cites W2162760851 @default.
• W2105593208 cites W2169913369 @default.
• W2105593208 cites W2182302387 @default.
• W2105593208 cites W2916192055 @default.
• W2105593208 doi "https://doi.org/10.1016/j.cyto.2007.05.001" @default.
• W2105593208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17587593" @default.
• W2105593208 hasPublicationYear "2007" @default.
• W2105593208 type Work @default.
• W2105593208 sameAs 2105593208 @default.
• W2105593208 citedByCount "64" @default.
• W2105593208 countsByYear W21055932082012 @default.
• W2105593208 countsByYear W21055932082013 @default.
• W2105593208 countsByYear W21055932082014 @default.
• W2105593208 countsByYear W21055932082015 @default.
• W2105593208 countsByYear W21055932082016 @default.
• W2105593208 countsByYear W21055932082017 @default.
• W2105593208 countsByYear W21055932082018 @default.
• W2105593208 countsByYear W21055932082019 @default.
• W2105593208 countsByYear W21055932082020 @default.
• W2105593208 countsByYear W21055932082021 @default.
• W2105593208 countsByYear W21055932082022 @default.
• W2105593208 countsByYear W21055932082023 @default.
• W2105593208 crossrefType "journal-article" @default.
• W2105593208 hasAuthorship W2105593208A5004069621 @default.
• W2105593208 hasAuthorship W2105593208A5004821647 @default.
• W2105593208 hasAuthorship W2105593208A5045259667 @default.
• W2105593208 hasConcept C101762097 @default.
• W2105593208 hasConcept C104317684 @default.
• W2105593208 hasConcept C107824862 @default.
• W2105593208 hasConcept C111936080 @default.
• W2105593208 hasConcept C135763542 @default.
• W2105593208 hasConcept C139275648 @default.
• W2105593208 hasConcept C149240914 @default.
• W2105593208 hasConcept C150194340 @default.
• W2105593208 hasConcept C153209595 @default.
• W2105593208 hasConcept C153911025 @default.
• W2105593208 hasConcept C179716448 @default.
• W2105593208 hasConcept C183978625 @default.
• W2105593208 hasConcept C2908647359 @default.
• W2105593208 hasConcept C54355233 @default.
• W2105593208 hasConcept C71924100 @default.
• W2105593208 hasConcept C86339819 @default.
• W2105593208 hasConcept C86803240 @default.
• W2105593208 hasConcept C94966510 @default.
• W2105593208 hasConcept C99454951 @default.
• W2105593208 hasConceptScore W2105593208C101762097 @default.
• W2105593208 hasConceptScore W2105593208C104317684 @default.
• W2105593208 hasConceptScore W2105593208C107824862 @default.
• W2105593208 hasConceptScore W2105593208C111936080 @default.
• W2105593208 hasConceptScore W2105593208C135763542 @default.
• W2105593208 hasConceptScore W2105593208C139275648 @default.
• W2105593208 hasConceptScore W2105593208C149240914 @default.
• W2105593208 hasConceptScore W2105593208C150194340 @default.
• W2105593208 hasConceptScore W2105593208C153209595 @default.
• W2105593208 hasConceptScore W2105593208C153911025 @default.
• W2105593208 hasConceptScore W2105593208C179716448 @default.
• W2105593208 hasConceptScore W2105593208C183978625 @default.
• W2105593208 hasConceptScore W2105593208C2908647359 @default.
• W2105593208 hasConceptScore W2105593208C54355233 @default.
• W2105593208 hasConceptScore W2105593208C71924100 @default.

• next