Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105607250> ?p ?o ?g. }
- W2105607250 endingPage "501" @default.
- W2105607250 startingPage "494" @default.
- W2105607250 abstract "Mutations within the coding region of hepatitis B surface antigen (HBsAg) have been found naturally in chronic carriers. To characterize the mutations of HBsAg from Iranian chronic carriers who were vaccine and/or medication naive. The surface genes from 360 patients were amplified and directly sequenced. The distribution of amino acid substitutions was classified according to different immune epitopes of the surface protein. All isolates belonged to genotype D. 222 (61.6%) of 360 patients contained at least one amino acid substitution. 404 (74.5%) of 542 amino acid changes occurred in different immune epitopes of HBsAg, of which 112 (27.7%) in 32 residues of B-cell epitopes (62 in the 'a' determinant); 111 (27.4%) in 32 residues of T helper; and 197 (48.7%) in 32 residues inside cytotoxic T lymphocyte (CTL) epitopes. One Th (186-197) and two CTL (28-51 and 206-215) epitopes were found to be hotspot motifs for the occurrence of 213 (52.7%) substitutions. 20 stop codons were identified in different epitopes. There was a significant association between amino acid substitutions and anti-HBe seropositivity; however, the correlation between such changes with viral load and ALT levels was not significant. In chronic hepatitis B virus(HBV) carriers, positive selection in particular outside the 'a' determinant appeared to exert influence on the surface proteins. These changes could be immune escape mutations naturally occurring due to the host immune surveillance especially at the T-cell level." @default.
- W2105607250 created "2016-06-24" @default.
- W2105607250 creator A5000785316 @default.
- W2105607250 creator A5001393704 @default.
- W2105607250 creator A5002215517 @default.
- W2105607250 creator A5003573801 @default.
- W2105607250 creator A5004189656 @default.
- W2105607250 creator A5006125849 @default.
- W2105607250 creator A5014214187 @default.
- W2105607250 creator A5019655471 @default.
- W2105607250 creator A5019820122 @default.
- W2105607250 creator A5020894927 @default.
- W2105607250 creator A5022015047 @default.
- W2105607250 creator A5023239580 @default.
- W2105607250 creator A5027802044 @default.
- W2105607250 creator A5028557504 @default.
- W2105607250 creator A5030453785 @default.
- W2105607250 creator A5031522711 @default.
- W2105607250 creator A5039260981 @default.
- W2105607250 creator A5043763376 @default.
- W2105607250 creator A5048255879 @default.
- W2105607250 creator A5056120424 @default.
- W2105607250 creator A5058402941 @default.
- W2105607250 creator A5059351708 @default.
- W2105607250 creator A5067166009 @default.
- W2105607250 creator A5070453929 @default.
- W2105607250 creator A5070899463 @default.
- W2105607250 creator A5071755606 @default.
- W2105607250 creator A5073442286 @default.
- W2105607250 creator A5075960475 @default.
- W2105607250 creator A5078898821 @default.
- W2105607250 creator A5089326449 @default.
- W2105607250 date "2013-04-25" @default.
- W2105607250 modified "2023-10-16" @default.
- W2105607250 title "Hepatitis B virus surface protein mutations clustered mainly in CTL immune epitopes in chronic carriers: results of an Iranian nationwide study" @default.
- W2105607250 cites W1502620477 @default.
- W2105607250 cites W1521203842 @default.
- W2105607250 cites W1556588515 @default.
- W2105607250 cites W1845254015 @default.
- W2105607250 cites W1941412003 @default.
- W2105607250 cites W1963644475 @default.
- W2105607250 cites W1964520444 @default.
- W2105607250 cites W1966912485 @default.
- W2105607250 cites W1972473823 @default.
- W2105607250 cites W1975027176 @default.
- W2105607250 cites W1976532144 @default.
- W2105607250 cites W1976606141 @default.
- W2105607250 cites W1980982139 @default.
- W2105607250 cites W1986377207 @default.
- W2105607250 cites W1986980855 @default.
- W2105607250 cites W1999298724 @default.
- W2105607250 cites W2019030498 @default.
- W2105607250 cites W2044965443 @default.
- W2105607250 cites W2046387499 @default.
- W2105607250 cites W2046848640 @default.
- W2105607250 cites W2046898131 @default.
- W2105607250 cites W2057157722 @default.
- W2105607250 cites W2070705282 @default.
- W2105607250 cites W2074328476 @default.
- W2105607250 cites W2083779678 @default.
- W2105607250 cites W2086645257 @default.
- W2105607250 cites W2091703661 @default.
- W2105607250 cites W2095576850 @default.
- W2105607250 cites W2100587714 @default.
- W2105607250 cites W2109237433 @default.
- W2105607250 cites W2135715865 @default.
- W2105607250 cites W2139028634 @default.
- W2105607250 cites W2143549931 @default.
- W2105607250 cites W2144685518 @default.
- W2105607250 cites W2149715912 @default.
- W2105607250 cites W2156089124 @default.
- W2105607250 cites W2166093525 @default.
- W2105607250 cites W2166274558 @default.
- W2105607250 doi "https://doi.org/10.1111/jvh.12045" @default.
- W2105607250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23730843" @default.
- W2105607250 hasPublicationYear "2013" @default.
- W2105607250 type Work @default.
- W2105607250 sameAs 2105607250 @default.
- W2105607250 citedByCount "22" @default.
- W2105607250 countsByYear W21056072502014 @default.
- W2105607250 countsByYear W21056072502015 @default.
- W2105607250 countsByYear W21056072502016 @default.
- W2105607250 countsByYear W21056072502017 @default.
- W2105607250 countsByYear W21056072502018 @default.
- W2105607250 countsByYear W21056072502019 @default.
- W2105607250 countsByYear W21056072502021 @default.
- W2105607250 countsByYear W21056072502022 @default.
- W2105607250 crossrefType "journal-article" @default.
- W2105607250 hasAuthorship W2105607250A5000785316 @default.
- W2105607250 hasAuthorship W2105607250A5001393704 @default.
- W2105607250 hasAuthorship W2105607250A5002215517 @default.
- W2105607250 hasAuthorship W2105607250A5003573801 @default.
- W2105607250 hasAuthorship W2105607250A5004189656 @default.
- W2105607250 hasAuthorship W2105607250A5006125849 @default.
- W2105607250 hasAuthorship W2105607250A5014214187 @default.
- W2105607250 hasAuthorship W2105607250A5019655471 @default.
- W2105607250 hasAuthorship W2105607250A5019820122 @default.
- W2105607250 hasAuthorship W2105607250A5020894927 @default.