Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105611421> ?p ?o ?g. }
- W2105611421 endingPage "1150" @default.
- W2105611421 startingPage "1137" @default.
- W2105611421 abstract "Abstract. Endothelin-1 (ET-1) has been implicated in the pathogenesis of renal inflammation. This study investigated the mechanisms underlying the synergistic upregulation of preproET-1 gene expression in human mesangial cells after co-stimulation with thrombin and tumor necrosis factor α (TNFα). Whereas thrombin induced a moderate upregulation of preproET-1 mRNA, co-stimulation with TNFα resulted in a strong and protracted upregulation of this mRNA species. Thrombin+TNFα-induced upregulation of preproET-1 expression was found to require p38 mitogen-activated protein kinase and protein kinases C, whereas activation of extracellular signal-regulated kinase, c-Jun-N-terminal kinase, or intracellular Ca2+ release were not required. Actinomycin D chase experiments suggested that enhanced stability of preproET-1 mRNA did not account for the increase in transcript levels. PreproET-1 promoter analysis demonstrated that the 5′-flanking region of preproET-1 encompassed positive regulatory elements engaged by thrombin. Negative modulation of thrombin-induced activation exerted by the distal 5′ portion of preproET-1 promoter (-4.4 kbp to 204 bp) was overcome by co-stimulation with TNFα, providing a possible mechanism underlying the synergistic upregulation of preproET-1 expression by these two agonists. In conclusion, human mesangial cell expression of preproET-1 may be increased potently in the presence of two common proinflammatory mediators, thereby providing a potential mechanism for ET-1 production in inflammatory renal disease." @default.
- W2105611421 created "2016-06-24" @default.
- W2105611421 creator A5024617116 @default.
- W2105611421 creator A5027600771 @default.
- W2105611421 creator A5036720975 @default.
- W2105611421 creator A5054400138 @default.
- W2105611421 creator A5068013917 @default.
- W2105611421 creator A5082322694 @default.
- W2105611421 creator A5088912114 @default.
- W2105611421 date "2001-06-01" @default.
- W2105611421 modified "2023-10-15" @default.
- W2105611421 title "PreproEndothelin-1 Expression in Human Mesangial Cells" @default.
- W2105611421 cites W1524164104 @default.
- W2105611421 cites W1548437752 @default.
- W2105611421 cites W1607853670 @default.
- W2105611421 cites W1667985597 @default.
- W2105611421 cites W1966103571 @default.
- W2105611421 cites W1969388212 @default.
- W2105611421 cites W1980523564 @default.
- W2105611421 cites W1985888026 @default.
- W2105611421 cites W2001521752 @default.
- W2105611421 cites W2013901451 @default.
- W2105611421 cites W2016080489 @default.
- W2105611421 cites W2028233788 @default.
- W2105611421 cites W2029354317 @default.
- W2105611421 cites W2030825143 @default.
- W2105611421 cites W2045702834 @default.
- W2105611421 cites W2056531599 @default.
- W2105611421 cites W2059046093 @default.
- W2105611421 cites W2063873782 @default.
- W2105611421 cites W2066895998 @default.
- W2105611421 cites W2071095066 @default.
- W2105611421 cites W2073414552 @default.
- W2105611421 cites W2076141383 @default.
- W2105611421 cites W2076584321 @default.
- W2105611421 cites W2086609326 @default.
- W2105611421 cites W2104840130 @default.
- W2105611421 cites W2105563670 @default.
- W2105611421 cites W2126543703 @default.
- W2105611421 cites W2133203551 @default.
- W2105611421 cites W2147144400 @default.
- W2105611421 cites W2161975618 @default.
- W2105611421 cites W2171832412 @default.
- W2105611421 cites W2171998192 @default.
- W2105611421 cites W2260108958 @default.
- W2105611421 cites W2336184170 @default.
- W2105611421 cites W2402181649 @default.
- W2105611421 cites W2408960331 @default.
- W2105611421 cites W4244089942 @default.
- W2105611421 doi "https://doi.org/10.1681/asn.v1261137" @default.
- W2105611421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11373337" @default.
- W2105611421 hasPublicationYear "2001" @default.
- W2105611421 type Work @default.
- W2105611421 sameAs 2105611421 @default.
- W2105611421 citedByCount "14" @default.
- W2105611421 countsByYear W21056114212012 @default.
- W2105611421 countsByYear W21056114212015 @default.
- W2105611421 countsByYear W21056114212020 @default.
- W2105611421 crossrefType "journal-article" @default.
- W2105611421 hasAuthorship W2105611421A5024617116 @default.
- W2105611421 hasAuthorship W2105611421A5027600771 @default.
- W2105611421 hasAuthorship W2105611421A5036720975 @default.
- W2105611421 hasAuthorship W2105611421A5054400138 @default.
- W2105611421 hasAuthorship W2105611421A5068013917 @default.
- W2105611421 hasAuthorship W2105611421A5082322694 @default.
- W2105611421 hasAuthorship W2105611421A5088912114 @default.
- W2105611421 hasBestOaLocation W21056114211 @default.
- W2105611421 hasConcept C104317684 @default.
- W2105611421 hasConcept C126322002 @default.
- W2105611421 hasConcept C127561419 @default.
- W2105611421 hasConcept C134018914 @default.
- W2105611421 hasConcept C149601957 @default.
- W2105611421 hasConcept C153911025 @default.
- W2105611421 hasConcept C164027704 @default.
- W2105611421 hasConcept C170493617 @default.
- W2105611421 hasConcept C17991360 @default.
- W2105611421 hasConcept C184235292 @default.
- W2105611421 hasConcept C185592680 @default.
- W2105611421 hasConcept C201267052 @default.
- W2105611421 hasConcept C2776914184 @default.
- W2105611421 hasConcept C2777292125 @default.
- W2105611421 hasConcept C2779131090 @default.
- W2105611421 hasConcept C2780091579 @default.
- W2105611421 hasConcept C28406088 @default.
- W2105611421 hasConcept C55493867 @default.
- W2105611421 hasConcept C71924100 @default.
- W2105611421 hasConcept C86803240 @default.
- W2105611421 hasConcept C89560881 @default.
- W2105611421 hasConcept C95444343 @default.
- W2105611421 hasConceptScore W2105611421C104317684 @default.
- W2105611421 hasConceptScore W2105611421C126322002 @default.
- W2105611421 hasConceptScore W2105611421C127561419 @default.
- W2105611421 hasConceptScore W2105611421C134018914 @default.
- W2105611421 hasConceptScore W2105611421C149601957 @default.
- W2105611421 hasConceptScore W2105611421C153911025 @default.
- W2105611421 hasConceptScore W2105611421C164027704 @default.
- W2105611421 hasConceptScore W2105611421C170493617 @default.
- W2105611421 hasConceptScore W2105611421C17991360 @default.