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- W2105635095 endingPage "50" @default.
- W2105635095 startingPage "141" @default.
- W2105635095 abstract "Oxidative stress, including the reactive oxygen or nitrogen species generated in the enzymatical oxidationor auto-oxidation of an excess amount of dopamine, is thought to play an important role in dopaminergic neurotoxicity. Dopamine and its metabolites containing 2 hydroxyl residues exert cytotoxicityin dopaminergic neuronal cells, primarily due to the generation of highly reactive dopamine and DOPA quinones. Dopamine and DOPA quinones may irreversibly alter protein function through the formation of 5-cysteinyl-catechols on the proteins. Furthermore, the quinone formation is closely linked to other representative hypotheses such as mitochondrial dysfunction, inflammation, oxidative stress, and dysfunction of the ubiquitin-proteasome system, in the pathogenesis of neurodegenerative diseases. Therefore, pathogenic effects of the dopamine quinone have recently focused on dopaminergicneuron-specific oxidative stress. In this article, we primarily review recent studies on the pathogenicity of quinone formation, in addition to several neuroprotective approaches against dopaminequinone-induced dysfunction of dopaminergic neurons." @default.
- W2105635095 created "2016-06-24" @default.
- W2105635095 creator A5026597336 @default.
- W2105635095 creator A5050295898 @default.
- W2105635095 date "2008-06-01" @default.
- W2105635095 modified "2023-09-23" @default.
- W2105635095 title "Dopaminergic neuron-specific oxidative stress caused by dopamine itself." @default.
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