FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105647513> ?p ?o ?g. }

• W2105647513 endingPage "1340" @default.
• W2105647513 startingPage "1333" @default.
• W2105647513 abstract "The Scleroderma Lung Study (SLS) demonstrated significant treatment-associated improvements in pulmonary function and symptoms when patients with scleroderma-related interstitial lung disease (SSc-ILD) were treated with a 1-year course of cyclophosphamide (CYC) in a randomized, double-blinded, placebo-controlled clinical trial. This study examined thoracic high-resolution CT (HRCT) scans obtained during the SLS for treatment-associated changes over time.Ninety-eight of the 158 subjects (CYC group, 49 subjects; placebo group, 49 subjects) participating in the SLS underwent thoracic HRCT scans both at baseline and after 12 months of treatment, which were available for analysis. Two independent radiologists visually scored the baseline HRCT scans for the presence of ground-glass opacities (GGOs), fibrosis (FIB), and honeycomb cysts (HCs) on a scale of 0 to 4. The treatment effect at 12 months was assessed by a blinded comparison of baseline and follow-up scans for evidence of stability and improvement (not worse) or deterioration (worse).At the end of treatment, FIB was significantly worse in the placebo treatment group than in the CYC treatment group (p = 0.014). Furthermore, differences in the 12-month change in FIB between the CYC and placebo groups correlated significantly with other outcome measures, including the 12-month changes in FVC (p < 0.05), total lung capacity (p < 0.05), and dyspnea (p < 0.001) scores. However, no differences were noted between the two groups with respect to changes in either GGOs or HCs.A 1-year course of treatment of SSc-ILD with CYC was associated with treatment-related changes in FIB scores on HRCT scans, which correlated with other measures of treatment response.ClinicalTrials.gov Identifier: NCT00004563." @default.
• W2105647513 created "2016-06-24" @default.
• W2105647513 creator A5006314383 @default.
• W2105647513 creator A5020701799 @default.
• W2105647513 creator A5023107984 @default.
• W2105647513 creator A5023897162 @default.
• W2105647513 creator A5045343022 @default.
• W2105647513 creator A5046865110 @default.
• W2105647513 creator A5049324725 @default.
• W2105647513 creator A5054987429 @default.
• W2105647513 creator A5056836366 @default.
• W2105647513 creator A5059206584 @default.
• W2105647513 creator A5062711392 @default.
• W2105647513 creator A5073269240 @default.
• W2105647513 creator A5074942308 @default.
• W2105647513 date "2009-11-01" @default.
• W2105647513 modified "2023-10-14" @default.
• W2105647513 title "Treatment of Scleroderma-Interstitial Lung Disease With Cyclophosphamide Is Associated With Less Progressive Fibrosis on Serial Thoracic High-Resolution CT Scan Than Placebo" @default.
• W2105647513 cites W1967413108 @default.
• W2105647513 cites W2016812439 @default.
• W2105647513 cites W2023466198 @default.
• W2105647513 cites W2042113729 @default.
• W2105647513 cites W2044225151 @default.
• W2105647513 cites W2050362215 @default.
• W2105647513 cites W2054919851 @default.
• W2105647513 cites W2056364917 @default.
• W2105647513 cites W2066165267 @default.
• W2105647513 cites W2066446621 @default.
• W2105647513 cites W2068038265 @default.
• W2105647513 cites W2102599668 @default.
• W2105647513 cites W2114540963 @default.
• W2105647513 cites W2116531828 @default.
• W2105647513 cites W2127353573 @default.
• W2105647513 cites W2131014787 @default.
• W2105647513 cites W2132946922 @default.
• W2105647513 cites W2136198835 @default.
• W2105647513 cites W2137071299 @default.
• W2105647513 cites W2147543851 @default.
• W2105647513 cites W2156807514 @default.
• W2105647513 cites W2166780351 @default.
• W2105647513 doi "https://doi.org/10.1378/chest.09-0108" @default.
• W2105647513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2773360" @default.
• W2105647513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19892673" @default.
• W2105647513 hasPublicationYear "2009" @default.
• W2105647513 type Work @default.
• W2105647513 sameAs 2105647513 @default.
• W2105647513 citedByCount "113" @default.
• W2105647513 countsByYear W21056475132012 @default.
• W2105647513 countsByYear W21056475132013 @default.
• W2105647513 countsByYear W21056475132014 @default.
• W2105647513 countsByYear W21056475132015 @default.
• W2105647513 countsByYear W21056475132016 @default.
• W2105647513 countsByYear W21056475132017 @default.
• W2105647513 countsByYear W21056475132018 @default.
• W2105647513 countsByYear W21056475132019 @default.
• W2105647513 countsByYear W21056475132020 @default.
• W2105647513 countsByYear W21056475132021 @default.
• W2105647513 countsByYear W21056475132022 @default.
• W2105647513 countsByYear W21056475132023 @default.
• W2105647513 crossrefType "journal-article" @default.
• W2105647513 hasAuthorship W2105647513A5006314383 @default.
• W2105647513 hasAuthorship W2105647513A5020701799 @default.
• W2105647513 hasAuthorship W2105647513A5023107984 @default.
• W2105647513 hasAuthorship W2105647513A5023897162 @default.
• W2105647513 hasAuthorship W2105647513A5045343022 @default.
• W2105647513 hasAuthorship W2105647513A5046865110 @default.
• W2105647513 hasAuthorship W2105647513A5049324725 @default.
• W2105647513 hasAuthorship W2105647513A5054987429 @default.
• W2105647513 hasAuthorship W2105647513A5056836366 @default.
• W2105647513 hasAuthorship W2105647513A5059206584 @default.
• W2105647513 hasAuthorship W2105647513A5062711392 @default.
• W2105647513 hasAuthorship W2105647513A5073269240 @default.
• W2105647513 hasAuthorship W2105647513A5074942308 @default.
• W2105647513 hasBestOaLocation W21056475132 @default.
• W2105647513 hasConcept C126322002 @default.
• W2105647513 hasConcept C126838900 @default.
• W2105647513 hasConcept C141071460 @default.
• W2105647513 hasConcept C142724271 @default.
• W2105647513 hasConcept C180032290 @default.
• W2105647513 hasConcept C204787440 @default.
• W2105647513 hasConcept C27081682 @default.
• W2105647513 hasConcept C2776694085 @default.
• W2105647513 hasConcept C2776755627 @default.
• W2105647513 hasConcept C2777524225 @default.
• W2105647513 hasConcept C2777543607 @default.
• W2105647513 hasConcept C2777714996 @default.
• W2105647513 hasConcept C2779967694 @default.
• W2105647513 hasConcept C71924100 @default.
• W2105647513 hasConcept C75603125 @default.
• W2105647513 hasConcept C90924648 @default.
• W2105647513 hasConceptScore W2105647513C126322002 @default.
• W2105647513 hasConceptScore W2105647513C126838900 @default.
• W2105647513 hasConceptScore W2105647513C141071460 @default.
• W2105647513 hasConceptScore W2105647513C142724271 @default.
• W2105647513 hasConceptScore W2105647513C180032290 @default.
• W2105647513 hasConceptScore W2105647513C204787440 @default.
• W2105647513 hasConceptScore W2105647513C27081682 @default.
• W2105647513 hasConceptScore W2105647513C2776694085 @default.

• next