FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105647593> ?p ?o ?g. }

• W2105647593 endingPage "C158" @default.
• W2105647593 startingPage "C148" @default.
• W2105647593 abstract "Cells respond to a wide range of mechanical stimuli such as fluid shear and strain, although the contribution of gravity to cell structure and function is not understood. We hypothesized that bone-forming osteoblasts are sensitive to increased mechanical loading by hypergravity. A centrifuge suitable for cell culture was developed and validated, and then primary cultures of fetal rat calvarial osteoblasts at various stages of differentiation were mechanically loaded using hypergravity. We measured microtubule network morphology as well as release of the paracrine factor prostaglandin E2 (PGE2). In immature osteoblasts, a stimulus of 10x gravity (10 g) for 3 h increased PGE2 2.5-fold and decreased microtubule network height 1.12-fold without affecting cell viability. Hypergravity (3 h) caused dose-dependent (5-50 g) increases in PGE2 (5.3-fold at 50 g) and decreases (1.26-fold at 50 g) in microtubule network height. PGE2 release depended on duration but not orientation of the hypergravity load. As osteoblasts differentiated, sensitivity to hypergravity declined. We conclude that primary osteoblasts demonstrate dose- and duration-dependent sensitivity to gravitational loading, which appears to be blunted in mature osteoblasts." @default.
• W2105647593 created "2016-06-24" @default.
• W2105647593 creator A5016581794 @default.
• W2105647593 creator A5016914844 @default.
• W2105647593 creator A5062582492 @default.
• W2105647593 date "2005-07-01" @default.
• W2105647593 modified "2023-09-26" @default.
• W2105647593 title "Influence of increased mechanical loading by hypergravity on the microtubule cytoskeleton and prostaglandin E₂release in primary osteoblasts" @default.
• W2105647593 cites W1770015027 @default.
• W2105647593 cites W1890394592 @default.
• W2105647593 cites W1932241391 @default.
• W2105647593 cites W1967333075 @default.
• W2105647593 cites W1967495080 @default.
• W2105647593 cites W1983443682 @default.
• W2105647593 cites W1989352695 @default.
• W2105647593 cites W1994579263 @default.
• W2105647593 cites W2000904875 @default.
• W2105647593 cites W2001149002 @default.
• W2105647593 cites W2015102924 @default.
• W2105647593 cites W2017859346 @default.
• W2105647593 cites W2017988945 @default.
• W2105647593 cites W2021958874 @default.
• W2105647593 cites W2023598672 @default.
• W2105647593 cites W2031531040 @default.
• W2105647593 cites W2034403497 @default.
• W2105647593 cites W2042764533 @default.
• W2105647593 cites W2043098612 @default.
• W2105647593 cites W2048690654 @default.
• W2105647593 cites W2064091987 @default.
• W2105647593 cites W2066702909 @default.
• W2105647593 cites W2072424207 @default.
• W2105647593 cites W2073130464 @default.
• W2105647593 cites W2077080519 @default.
• W2105647593 cites W2085989796 @default.
• W2105647593 cites W2089194398 @default.
• W2105647593 cites W2090038909 @default.
• W2105647593 cites W2095857644 @default.
• W2105647593 cites W2096292802 @default.
• W2105647593 cites W2099126164 @default.
• W2105647593 cites W2114869892 @default.
• W2105647593 cites W2118697424 @default.
• W2105647593 cites W2122543608 @default.
• W2105647593 cites W2129611079 @default.
• W2105647593 cites W2132309525 @default.
• W2105647593 cites W2153921426 @default.
• W2105647593 cites W2159459710 @default.
• W2105647593 cites W2161681303 @default.
• W2105647593 cites W2171662317 @default.
• W2105647593 cites W2189021327 @default.
• W2105647593 cites W2269458787 @default.
• W2105647593 cites W2314068974 @default.
• W2105647593 cites W2473404851 @default.
• W2105647593 cites W4249441050 @default.
• W2105647593 cites W4300038485 @default.
• W2105647593 doi "https://doi.org/10.1152/ajpcell.00524.2003" @default.
• W2105647593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15728710" @default.
• W2105647593 hasPublicationYear "2005" @default.
• W2105647593 type Work @default.
• W2105647593 sameAs 2105647593 @default.
• W2105647593 citedByCount "55" @default.
• W2105647593 countsByYear W21056475932012 @default.
• W2105647593 countsByYear W21056475932013 @default.
• W2105647593 countsByYear W21056475932014 @default.
• W2105647593 countsByYear W21056475932015 @default.
• W2105647593 countsByYear W21056475932016 @default.
• W2105647593 countsByYear W21056475932018 @default.
• W2105647593 countsByYear W21056475932019 @default.
• W2105647593 countsByYear W21056475932021 @default.
• W2105647593 countsByYear W21056475932022 @default.
• W2105647593 crossrefType "journal-article" @default.
• W2105647593 hasAuthorship W2105647593A5016581794 @default.
• W2105647593 hasAuthorship W2105647593A5016914844 @default.
• W2105647593 hasAuthorship W2105647593A5062582492 @default.
• W2105647593 hasConcept C12554922 @default.
• W2105647593 hasConcept C126322002 @default.
• W2105647593 hasConcept C128709446 @default.
• W2105647593 hasConcept C134018914 @default.
• W2105647593 hasConcept C142669718 @default.
• W2105647593 hasConcept C1491633281 @default.
• W2105647593 hasConcept C170493617 @default.
• W2105647593 hasConcept C185592680 @default.
• W2105647593 hasConcept C202751555 @default.
• W2105647593 hasConcept C20418707 @default.
• W2105647593 hasConcept C2777956040 @default.
• W2105647593 hasConcept C2778260815 @default.
• W2105647593 hasConcept C2780171871 @default.
• W2105647593 hasConcept C55493867 @default.
• W2105647593 hasConcept C71924100 @default.
• W2105647593 hasConcept C7876069 @default.
• W2105647593 hasConcept C86803240 @default.
• W2105647593 hasConcept C95444343 @default.
• W2105647593 hasConceptScore W2105647593C12554922 @default.
• W2105647593 hasConceptScore W2105647593C126322002 @default.
• W2105647593 hasConceptScore W2105647593C128709446 @default.
• W2105647593 hasConceptScore W2105647593C134018914 @default.
• W2105647593 hasConceptScore W2105647593C142669718 @default.
• W2105647593 hasConceptScore W2105647593C1491633281 @default.
• W2105647593 hasConceptScore W2105647593C170493617 @default.

• next