Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105649103> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2105649103 abstract "We have recently shown that T-antigen binding to Site I results in the replication-dependent introduction of H3K9me1 into SV40 chromatin late in infection. Since H3K9me2 and H3K9me3 are also present late in infection, we determined whether their presence was also related to the status of ongoing transcription and replication. Transcription was either inhibited with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidizole (DRB) or stimulated with sodium butyrate and the effects on histone modifications early and late in infection determined. The role of DNA replication was determined by concomitant inhibition of replication with aphidicolin. We observed that H3K9me2/me3 was specifically introduced when transcription was inhibited during active replication. The introduction of H3K9me2/me3 that occurred when transcription was inhibited was partially blocked when replication was also inhibited. The introduction of H3K9me2/me3 did not require the presence of H3K9me1 since similar results were obtained with the mutant cs1085 whose chromatin contains very little H3K9me1. Our data suggest that methylation of H3K9 can occur either as a consequence of a specific repressive event such as T-antigen binding to Site I or as a result of a general repression of transcription in the presence of active replication. The results suggest that the nonproductive generation of transcription complexes as occurs following DRB treatment may be recognized by a ‘proof reading’ mechanism, which leads to the specific introduction of H3K9me2 and H3K9me3." @default.
- W2105649103 created "2016-06-24" @default.
- W2105649103 creator A5031131396 @default.
- W2105649103 creator A5039370981 @default.
- W2105649103 creator A5063188450 @default.
- W2105649103 creator A5067167093 @default.
- W2105649103 date "2014-10-27" @default.
- W2105649103 modified "2023-09-24" @default.
- W2105649103 title "Transcriptional repression is epigenetically marked by H3K9 methylation during SV40 replication" @default.
- W2105649103 cites W1506966309 @default.
- W2105649103 cites W1985445406 @default.
- W2105649103 cites W1985634754 @default.
- W2105649103 cites W1987293281 @default.
- W2105649103 cites W2002794419 @default.
- W2105649103 cites W2012598468 @default.
- W2105649103 cites W2018051857 @default.
- W2105649103 cites W2024551462 @default.
- W2105649103 cites W2034942453 @default.
- W2105649103 cites W2040635899 @default.
- W2105649103 cites W2054357032 @default.
- W2105649103 cites W2057564306 @default.
- W2105649103 cites W2060355887 @default.
- W2105649103 cites W2082662254 @default.
- W2105649103 cites W2083228706 @default.
- W2105649103 cites W2090317582 @default.
- W2105649103 cites W2095626300 @default.
- W2105649103 cites W2105617035 @default.
- W2105649103 cites W2129541042 @default.
- W2105649103 cites W2130350241 @default.
- W2105649103 cites W2158747282 @default.
- W2105649103 cites W2168098507 @default.
- W2105649103 cites W2169763675 @default.
- W2105649103 doi "https://doi.org/10.1186/1868-7083-6-21" @default.
- W2105649103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4230732" @default.
- W2105649103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25395994" @default.
- W2105649103 hasPublicationYear "2014" @default.
- W2105649103 type Work @default.
- W2105649103 sameAs 2105649103 @default.
- W2105649103 citedByCount "11" @default.
- W2105649103 countsByYear W21056491032016 @default.
- W2105649103 countsByYear W21056491032017 @default.
- W2105649103 countsByYear W21056491032018 @default.
- W2105649103 countsByYear W21056491032019 @default.
- W2105649103 countsByYear W21056491032020 @default.
- W2105649103 crossrefType "journal-article" @default.
- W2105649103 hasAuthorship W2105649103A5031131396 @default.
- W2105649103 hasAuthorship W2105649103A5039370981 @default.
- W2105649103 hasAuthorship W2105649103A5063188450 @default.
- W2105649103 hasAuthorship W2105649103A5067167093 @default.
- W2105649103 hasBestOaLocation W21056491031 @default.
- W2105649103 hasConcept C138885662 @default.
- W2105649103 hasConcept C151158763 @default.
- W2105649103 hasConcept C153911025 @default.
- W2105649103 hasConcept C179926584 @default.
- W2105649103 hasConcept C2776253266 @default.
- W2105649103 hasConcept C41895202 @default.
- W2105649103 hasConcept C54355233 @default.
- W2105649103 hasConcept C552990157 @default.
- W2105649103 hasConcept C64927066 @default.
- W2105649103 hasConcept C73573662 @default.
- W2105649103 hasConcept C83640560 @default.
- W2105649103 hasConcept C86803240 @default.
- W2105649103 hasConcept C95444343 @default.
- W2105649103 hasConcept C98086919 @default.
- W2105649103 hasConceptScore W2105649103C138885662 @default.
- W2105649103 hasConceptScore W2105649103C151158763 @default.
- W2105649103 hasConceptScore W2105649103C153911025 @default.
- W2105649103 hasConceptScore W2105649103C179926584 @default.
- W2105649103 hasConceptScore W2105649103C2776253266 @default.
- W2105649103 hasConceptScore W2105649103C41895202 @default.
- W2105649103 hasConceptScore W2105649103C54355233 @default.
- W2105649103 hasConceptScore W2105649103C552990157 @default.
- W2105649103 hasConceptScore W2105649103C64927066 @default.
- W2105649103 hasConceptScore W2105649103C73573662 @default.
- W2105649103 hasConceptScore W2105649103C83640560 @default.
- W2105649103 hasConceptScore W2105649103C86803240 @default.
- W2105649103 hasConceptScore W2105649103C95444343 @default.
- W2105649103 hasConceptScore W2105649103C98086919 @default.
- W2105649103 hasIssue "1" @default.
- W2105649103 hasLocation W21056491031 @default.
- W2105649103 hasLocation W21056491032 @default.
- W2105649103 hasLocation W21056491033 @default.
- W2105649103 hasLocation W21056491034 @default.
- W2105649103 hasOpenAccess W2105649103 @default.
- W2105649103 hasPrimaryLocation W21056491031 @default.
- W2105649103 hasRelatedWork W2054074488 @default.
- W2105649103 hasRelatedWork W2127316404 @default.
- W2105649103 hasRelatedWork W2127859791 @default.
- W2105649103 hasRelatedWork W2142827745 @default.
- W2105649103 hasRelatedWork W2159207147 @default.
- W2105649103 hasRelatedWork W3109508430 @default.
- W2105649103 hasRelatedWork W3209309754 @default.
- W2105649103 hasRelatedWork W3214155539 @default.
- W2105649103 hasRelatedWork W4200156210 @default.
- W2105649103 hasRelatedWork W615203 @default.
- W2105649103 hasVolume "6" @default.
- W2105649103 isParatext "false" @default.
- W2105649103 isRetracted "false" @default.
- W2105649103 magId "2105649103" @default.
- W2105649103 workType "article" @default.