FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105651542> ?p ?o ?g. }

• W2105651542 endingPage "1329" @default.
• W2105651542 startingPage "1320" @default.
• W2105651542 abstract "Adipose tissue inflammation has been linked to age-related metabolic diseases. However, the underlying mechanisms are poorly understood. Adipose tissue inflammation and insulin resistance in diet associated obesity has been correlated with aberrant endoplasmic reticulum (ER) stress. This study was undertaken to test our hypothesis that increased ER stress response contributes to age-associated adipose tissue inflammation. We found elevated ER stress response in adipose tissue of old (18–20 months) compared to young (4–6 months) mice. Elevated ER stress markers BIP (GRP78), CHOP, cleaved-ATF-6, phospho-IRE1α, and XBP-1 were observed in old compared to young adipose tissue stromal cells. Additionally, old adipose tissue stromal cells were more sensitive to an ER stress inducer, thapsigargin. Similar experiments with adipose tissue macrophages showed elevated Chop and Bip expression in old adipose tissue macrophages when induced with thapsigargin. Treatment of chemical chaperone 4-phenyle-butyric acid alleviated ER stress in adipose tissue stromal cells and adipose tissue macrophages and attenuated the production of IL-6 and MCP-1 by adipose tissue stromal cells, and TNF-α by adipose tissue macrophages from both young and old mice. Finally, old mice fed with 4-phenyle-butyric acid have reduced expression of ER stress and inflammatory cytokine genes. Our data suggests that an exaggerated ER stress response in aging adipose tissue contributes to age-associated inflammation that can be mitigated by treatment with chemical chaperones." @default.
• W2105651542 created "2016-06-24" @default.
• W2105651542 creator A5008473098 @default.
• W2105651542 creator A5041057598 @default.
• W2105651542 creator A5056836601 @default.
• W2105651542 creator A5072691960 @default.
• W2105651542 creator A5075224523 @default.
• W2105651542 creator A5088877031 @default.
• W2105651542 date "2014-10-16" @default.
• W2105651542 modified "2023-10-16" @default.
• W2105651542 title "Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging" @default.
• W2105651542 cites W1519843125 @default.
• W2105651542 cites W1524204416 @default.
• W2105651542 cites W1638473681 @default.
• W2105651542 cites W1773423156 @default.
• W2105651542 cites W1965514223 @default.
• W2105651542 cites W1977603207 @default.
• W2105651542 cites W1985313675 @default.
• W2105651542 cites W1988973837 @default.
• W2105651542 cites W1989051519 @default.
• W2105651542 cites W1989792311 @default.
• W2105651542 cites W2000054651 @default.
• W2105651542 cites W2007078899 @default.
• W2105651542 cites W2007505836 @default.
• W2105651542 cites W2013966513 @default.
• W2105651542 cites W2025347981 @default.
• W2105651542 cites W2028611243 @default.
• W2105651542 cites W2034213169 @default.
• W2105651542 cites W2041329280 @default.
• W2105651542 cites W2048101387 @default.
• W2105651542 cites W2048456744 @default.
• W2105651542 cites W2059404699 @default.
• W2105651542 cites W2069054312 @default.
• W2105651542 cites W2071046609 @default.
• W2105651542 cites W2080612159 @default.
• W2105651542 cites W2089198803 @default.
• W2105651542 cites W2101328621 @default.
• W2105651542 cites W2101555125 @default.
• W2105651542 cites W2127848114 @default.
• W2105651542 cites W2131250713 @default.
• W2105651542 cites W2137755719 @default.
• W2105651542 cites W2152409987 @default.
• W2105651542 cites W2165604976 @default.
• W2105651542 cites W2165678812 @default.
• W2105651542 cites W2170939329 @default.
• W2105651542 doi "https://doi.org/10.1093/gerona/glu186" @default.
• W2105651542 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4612381" @default.
• W2105651542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25324219" @default.
• W2105651542 hasPublicationYear "2014" @default.
• W2105651542 type Work @default.
• W2105651542 sameAs 2105651542 @default.
• W2105651542 citedByCount "66" @default.
• W2105651542 countsByYear W21056515422016 @default.
• W2105651542 countsByYear W21056515422017 @default.
• W2105651542 countsByYear W21056515422018 @default.
• W2105651542 countsByYear W21056515422019 @default.
• W2105651542 countsByYear W21056515422020 @default.
• W2105651542 countsByYear W21056515422021 @default.
• W2105651542 countsByYear W21056515422022 @default.
• W2105651542 crossrefType "journal-article" @default.
• W2105651542 hasAuthorship W2105651542A5008473098 @default.
• W2105651542 hasAuthorship W2105651542A5041057598 @default.
• W2105651542 hasAuthorship W2105651542A5056836601 @default.
• W2105651542 hasAuthorship W2105651542A5072691960 @default.
• W2105651542 hasAuthorship W2105651542A5075224523 @default.
• W2105651542 hasAuthorship W2105651542A5088877031 @default.
• W2105651542 hasBestOaLocation W21056515421 @default.
• W2105651542 hasConcept C126322002 @default.
• W2105651542 hasConcept C134018914 @default.
• W2105651542 hasConcept C139447449 @default.
• W2105651542 hasConcept C151955695 @default.
• W2105651542 hasConcept C158617107 @default.
• W2105651542 hasConcept C16930146 @default.
• W2105651542 hasConcept C171089720 @default.
• W2105651542 hasConcept C17675752 @default.
• W2105651542 hasConcept C2776914184 @default.
• W2105651542 hasConcept C71924100 @default.
• W2105651542 hasConcept C86803240 @default.
• W2105651542 hasConcept C95444343 @default.
• W2105651542 hasConceptScore W2105651542C126322002 @default.
• W2105651542 hasConceptScore W2105651542C134018914 @default.
• W2105651542 hasConceptScore W2105651542C139447449 @default.
• W2105651542 hasConceptScore W2105651542C151955695 @default.
• W2105651542 hasConceptScore W2105651542C158617107 @default.
• W2105651542 hasConceptScore W2105651542C16930146 @default.
• W2105651542 hasConceptScore W2105651542C171089720 @default.
• W2105651542 hasConceptScore W2105651542C17675752 @default.
• W2105651542 hasConceptScore W2105651542C2776914184 @default.
• W2105651542 hasConceptScore W2105651542C71924100 @default.
• W2105651542 hasConceptScore W2105651542C86803240 @default.
• W2105651542 hasConceptScore W2105651542C95444343 @default.
• W2105651542 hasIssue "11" @default.
• W2105651542 hasLocation W21056515421 @default.
• W2105651542 hasLocation W21056515422 @default.
• W2105651542 hasLocation W21056515423 @default.
• W2105651542 hasLocation W21056515424 @default.
• W2105651542 hasOpenAccess W2105651542 @default.
• W2105651542 hasPrimaryLocation W21056515421 @default.

• next