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• W2105655167 abstract "Significance Uracil DNA glycosylase (UNG) has been known as a critical base excision repair protein required for class switch recombination (CSR) and somatic hypermutation (SHM). On the other hand, its precise function in both CSR and SHM is extremely debatable and elusive. Here, we showed that UNG suppresses S region SHM (s-SHM) by recruiting the faithful DNA repair complex and, in the absence of UNG, the error-prone repair complex that induces s-SHM overrides. Moreover, UNG promotes activation-induced cytidine deaminase-induced CSR by regulating S-S synapse and DNA end repair. Interestingly, the enzymatic activity of UNG is dispensable for s-SHM suppression and CSR promotion." @default.
• W2105655167 created "2016-06-24" @default.
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• W2105655167 date "2014-03-03" @default.
• W2105655167 modified "2023-09-23" @default.
• W2105655167 title "Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase" @default.
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• W2105655167 doi "https://doi.org/10.1073/pnas.1402391111" @default.
• W2105655167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3964042" @default.
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• W2105655167 hasPublicationYear "2014" @default.
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