FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105655461> ?p ?o ?g. }

• W2105655461 endingPage "425" @default.
• W2105655461 startingPage "414" @default.
• W2105655461 abstract "Multicellular organisms maintain form and function through a multitude of homeostatic mechanisms. The details of these mechanisms are in many cases unknown, and so are their evolutionary origin and their link to development. In order to illuminate these issues we have investigated the evolution of structural homeostasis in the simplest of cases, a tissue formed by a mono-layer of cells. To this end, we made use of a 3-dimensional hybrid cellular automaton, an individual-based model in which the behaviour of each cell depends on its local environment. Using an evolutionary algorithm (EA) we evolved cell signalling networks, both with a fixed and an incremental fitness evaluation, which give rise to and maintain a mono-layer tissue structure. Analysis of the solutions provided by the EA shows that the two evaluation methods gives rise to different types of solutions to the problem of homeostasis. The fixed method leads to almost optimal solutions, where the tissue relies on a high rate of cell turnover, while the solutions from the incremental scheme behave in a more conservative manner, only dividing when necessary. In order to test the robustness of the solutions we subjected them to environmental stress, by wounding the tissue, and to genetic stress, by introducing mutations. The results show that the robustness very much depends on the mechanism responsible for maintaining homeostasis. The two evolved cell types analysed present contrasting mechanisms by which tissue homeostasis can be maintained. This compares well to different tissue types found in multicellular organisms. For example the epithelial cells lining the colon in humans are shed at a considerable rate, while in other tissue types, which are not as exposed, the conservative type of homeostatic mechanism is normally found. These results will hopefully shed light on how multicellular organisms have evolved homeostatic mechanisms and what might occur when these mechanisms fail, as in the case of cancer." @default.
• W2105655461 created "2016-06-24" @default.
• W2105655461 creator A5003774553 @default.
• W2105655461 creator A5060674598 @default.
• W2105655461 creator A5069870901 @default.
• W2105655461 date "2011-08-01" @default.
• W2105655461 modified "2023-09-25" @default.
• W2105655461 title "Evolving homeostatic tissue using genetic algorithms" @default.
• W2105655461 cites W1555386903 @default.
• W2105655461 cites W1965995005 @default.
• W2105655461 cites W1971083544 @default.
• W2105655461 cites W1981962653 @default.
• W2105655461 cites W1991370659 @default.
• W2105655461 cites W1992909271 @default.
• W2105655461 cites W2000572318 @default.
• W2105655461 cites W2004781757 @default.
• W2105655461 cites W2010494194 @default.
• W2105655461 cites W2012895010 @default.
• W2105655461 cites W2015594324 @default.
• W2105655461 cites W2016350172 @default.
• W2105655461 cites W2025521327 @default.
• W2105655461 cites W2029602209 @default.
• W2105655461 cites W2034269086 @default.
• W2105655461 cites W2042332837 @default.
• W2105655461 cites W2042835353 @default.
• W2105655461 cites W2045484383 @default.
• W2105655461 cites W2045702252 @default.
• W2105655461 cites W2046585679 @default.
• W2105655461 cites W2048195900 @default.
• W2105655461 cites W2070004581 @default.
• W2105655461 cites W2084336885 @default.
• W2105655461 cites W2085447706 @default.
• W2105655461 cites W2100716078 @default.
• W2105655461 cites W2105557836 @default.
• W2105655461 cites W2108690261 @default.
• W2105655461 cites W2134047171 @default.
• W2105655461 cites W2135232979 @default.
• W2105655461 cites W2137304168 @default.
• W2105655461 cites W2151784208 @default.
• W2105655461 cites W2153684665 @default.
• W2105655461 cites W2166223265 @default.
• W2105655461 doi "https://doi.org/10.1016/j.pbiomolbio.2011.03.004" @default.
• W2105655461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3812677" @default.
• W2105655461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21419156" @default.
• W2105655461 hasPublicationYear "2011" @default.
• W2105655461 type Work @default.
• W2105655461 sameAs 2105655461 @default.
• W2105655461 citedByCount "21" @default.
• W2105655461 countsByYear W21056554612013 @default.
• W2105655461 countsByYear W21056554612015 @default.
• W2105655461 countsByYear W21056554612016 @default.
• W2105655461 countsByYear W21056554612017 @default.
• W2105655461 countsByYear W21056554612018 @default.
• W2105655461 countsByYear W21056554612019 @default.
• W2105655461 countsByYear W21056554612020 @default.
• W2105655461 countsByYear W21056554612021 @default.
• W2105655461 crossrefType "journal-article" @default.
• W2105655461 hasAuthorship W2105655461A5003774553 @default.
• W2105655461 hasAuthorship W2105655461A5060674598 @default.
• W2105655461 hasAuthorship W2105655461A5069870901 @default.
• W2105655461 hasBestOaLocation W21056554612 @default.
• W2105655461 hasConcept C104317684 @default.
• W2105655461 hasConcept C11413529 @default.
• W2105655461 hasConcept C1491633281 @default.
• W2105655461 hasConcept C35527583 @default.
• W2105655461 hasConcept C41008148 @default.
• W2105655461 hasConcept C54355233 @default.
• W2105655461 hasConcept C63479239 @default.
• W2105655461 hasConcept C63645605 @default.
• W2105655461 hasConcept C74318829 @default.
• W2105655461 hasConcept C86803240 @default.
• W2105655461 hasConcept C95444343 @default.
• W2105655461 hasConceptScore W2105655461C104317684 @default.
• W2105655461 hasConceptScore W2105655461C11413529 @default.
• W2105655461 hasConceptScore W2105655461C1491633281 @default.
• W2105655461 hasConceptScore W2105655461C35527583 @default.
• W2105655461 hasConceptScore W2105655461C41008148 @default.
• W2105655461 hasConceptScore W2105655461C54355233 @default.
• W2105655461 hasConceptScore W2105655461C63479239 @default.
• W2105655461 hasConceptScore W2105655461C63645605 @default.
• W2105655461 hasConceptScore W2105655461C74318829 @default.
• W2105655461 hasConceptScore W2105655461C86803240 @default.
• W2105655461 hasConceptScore W2105655461C95444343 @default.
• W2105655461 hasIssue "2" @default.
• W2105655461 hasLocation W21056554611 @default.
• W2105655461 hasLocation W21056554612 @default.
• W2105655461 hasLocation W21056554613 @default.
• W2105655461 hasLocation W21056554614 @default.
• W2105655461 hasOpenAccess W2105655461 @default.
• W2105655461 hasPrimaryLocation W21056554611 @default.
• W2105655461 hasRelatedWork W1965966613 @default.
• W2105655461 hasRelatedWork W1993153951 @default.
• W2105655461 hasRelatedWork W2014037121 @default.
• W2105655461 hasRelatedWork W2044499740 @default.
• W2105655461 hasRelatedWork W2166116549 @default.
• W2105655461 hasRelatedWork W2257886946 @default.
• W2105655461 hasRelatedWork W2584455473 @default.
• W2105655461 hasRelatedWork W2959065967 @default.

• next