FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105659969> ?p ?o ?g. }

• W2105659969 endingPage "505" @default.
• W2105659969 startingPage "499" @default.
• W2105659969 abstract "Bone marrow (BM) cells that were concentrated for hematopoietic progenitor cells by in vivo treatment with 5-FU were infected with a recombinant retrovirus containing a human full-sized, non-spliced type WT1 (Wilms’ tumor gene 1) cDNA and then colony-assayed in the presence of granulocyte-colony stimulating factor (G-CSF). Significantly more colony-forming units granulocyte-monocyte (CFU-GM), colony-forming units granulocyte (CFU-G), and colony-forming units monocyte (CFU-M) colonies were formed in response to G-CSF from the BM cells infected with the WT1-containing retrovirus than from the control BM cells infected with an empty vector. Furthermore, FACS analysis of cell surface differentiation markers showed the inhibition of differentiation by constitutive WT1 expression resulting from the infection with the WT1-containing retrovirus. These results thus showed that the constitutive WT1 expression promoted the proliferation of myeloid progenitor cells but inhibited their differentiation in response to G-CSF, suggesting the alteration of G-CSF signaling pathway. The results also supported our hypothesis that the WT1 gene performs an oncogenic rather than a tumor suppressor gene function in hematopoietic progenitor cells, although the WT1 gene potentially performs both functions. This finding implies an important role of the WT1 gene in leukemogenesis." @default.
• W2105659969 created "2016-06-24" @default.
• W2105659969 creator A5011392452 @default.
• W2105659969 creator A5021069937 @default.
• W2105659969 creator A5021463605 @default.
• W2105659969 creator A5024904221 @default.
• W2105659969 creator A5037467732 @default.
• W2105659969 creator A5038214190 @default.
• W2105659969 creator A5039545366 @default.
• W2105659969 creator A5065367171 @default.
• W2105659969 creator A5067917737 @default.
• W2105659969 creator A5071157110 @default.
• W2105659969 creator A5075361766 @default.
• W2105659969 creator A5081482977 @default.
• W2105659969 date "1999-05-01" @default.
• W2105659969 modified "2023-10-14" @default.
• W2105659969 title "Constitutive expression of the Wilms’ tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF)" @default.
• W2105659969 cites W109011834 @default.
• W2105659969 cites W124601896 @default.
• W2105659969 cites W1493021534 @default.
• W2105659969 cites W1498565802 @default.
• W2105659969 cites W1966630774 @default.
• W2105659969 cites W1973418379 @default.
• W2105659969 cites W1993951035 @default.
• W2105659969 cites W1998109615 @default.
• W2105659969 cites W2010791130 @default.
• W2105659969 cites W2013758383 @default.
• W2105659969 cites W2057204569 @default.
• W2105659969 cites W2096381270 @default.
• W2105659969 cites W2148069086 @default.
• W2105659969 cites W2152151858 @default.
• W2105659969 cites W2154476554 @default.
• W2105659969 cites W2156593102 @default.
• W2105659969 cites W2249166705 @default.
• W2105659969 cites W2261769285 @default.
• W2105659969 cites W2268105212 @default.
• W2105659969 cites W2333876550 @default.
• W2105659969 cites W2395138166 @default.
• W2105659969 cites W2409854937 @default.
• W2105659969 cites W4230054373 @default.
• W2105659969 cites W4235771239 @default.
• W2105659969 cites W4241143165 @default.
• W2105659969 doi "https://doi.org/10.1016/s0145-2126(99)00037-5" @default.
• W2105659969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10374864" @default.
• W2105659969 hasPublicationYear "1999" @default.
• W2105659969 type Work @default.
• W2105659969 sameAs 2105659969 @default.
• W2105659969 citedByCount "96" @default.
• W2105659969 countsByYear W21056599692012 @default.
• W2105659969 countsByYear W21056599692013 @default.
• W2105659969 countsByYear W21056599692014 @default.
• W2105659969 countsByYear W21056599692015 @default.
• W2105659969 countsByYear W21056599692016 @default.
• W2105659969 countsByYear W21056599692017 @default.
• W2105659969 countsByYear W21056599692018 @default.
• W2105659969 countsByYear W21056599692019 @default.
• W2105659969 countsByYear W21056599692021 @default.
• W2105659969 countsByYear W21056599692022 @default.
• W2105659969 crossrefType "journal-article" @default.
• W2105659969 hasAuthorship W2105659969A5011392452 @default.
• W2105659969 hasAuthorship W2105659969A5021069937 @default.
• W2105659969 hasAuthorship W2105659969A5021463605 @default.
• W2105659969 hasAuthorship W2105659969A5024904221 @default.
• W2105659969 hasAuthorship W2105659969A5037467732 @default.
• W2105659969 hasAuthorship W2105659969A5038214190 @default.
• W2105659969 hasAuthorship W2105659969A5039545366 @default.
• W2105659969 hasAuthorship W2105659969A5065367171 @default.
• W2105659969 hasAuthorship W2105659969A5067917737 @default.
• W2105659969 hasAuthorship W2105659969A5071157110 @default.
• W2105659969 hasAuthorship W2105659969A5075361766 @default.
• W2105659969 hasAuthorship W2105659969A5081482977 @default.
• W2105659969 hasConcept C109159458 @default.
• W2105659969 hasConcept C129374314 @default.
• W2105659969 hasConcept C131665280 @default.
• W2105659969 hasConcept C14942488 @default.
• W2105659969 hasConcept C153911025 @default.
• W2105659969 hasConcept C201750760 @default.
• W2105659969 hasConcept C203014093 @default.
• W2105659969 hasConcept C2776090121 @default.
• W2105659969 hasConcept C2776694085 @default.
• W2105659969 hasConcept C2777767877 @default.
• W2105659969 hasConcept C2777983669 @default.
• W2105659969 hasConcept C2779282312 @default.
• W2105659969 hasConcept C2781184567 @default.
• W2105659969 hasConcept C28328180 @default.
• W2105659969 hasConcept C502942594 @default.
• W2105659969 hasConcept C54355233 @default.
• W2105659969 hasConcept C86803240 @default.
• W2105659969 hasConcept C8891405 @default.
• W2105659969 hasConcept C95444343 @default.
• W2105659969 hasConcept C95862172 @default.
• W2105659969 hasConceptScore W2105659969C109159458 @default.
• W2105659969 hasConceptScore W2105659969C129374314 @default.
• W2105659969 hasConceptScore W2105659969C131665280 @default.
• W2105659969 hasConceptScore W2105659969C14942488 @default.
• W2105659969 hasConceptScore W2105659969C153911025 @default.
• W2105659969 hasConceptScore W2105659969C201750760 @default.
• W2105659969 hasConceptScore W2105659969C203014093 @default.

• next