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- W2105661731 abstract "Neovascular age-related macular degeneration (AMD) is currently the most common cause of legal blindness in industrialized countries. The advent of pharmacotherapy with intravitreal VEGF inhibitors has greatly improved outcomes for the treatment of this disease.The present review is divided into two major sections: the period prior to the use of anti-VEGF agents (triamcinolone acetonide, verteporfin photodynamic therapy) and the period following their introduction (pegaptanib sodium, bevacizumab, ranibizumab, aflibercept). The main pharmacological and clinical characteristics of each therapy are summarized.Monotherapy with anti-VEGF agents is currently the 'gold standard' for treating neovascular AMD, but, with several drug choices and various different dosing regimens available, there is still wide variability in how individual clinicians manage their patients. Despite improved visual outcomes, there remains a significant unmet need for better treatments as the frequent office visits and injections associated with anti-VEGF therapy are costly and place a significant burden on patients, their family members and physicians." @default.
- W2105661731 created "2016-06-24" @default.
- W2105661731 creator A5019296720 @default.
- W2105661731 creator A5069307390 @default.
- W2105661731 creator A5083774543 @default.
- W2105661731 date "2013-04-08" @default.
- W2105661731 modified "2023-10-16" @default.
- W2105661731 title "An update on the pharmacotherapy of neovascular age-related macular degeneration" @default.
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- W2105661731 doi "https://doi.org/10.1517/14656566.2013.787410" @default.
- W2105661731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23560774" @default.
- W2105661731 hasPublicationYear "2013" @default.
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