FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105671007> ?p ?o ?g. }

• W2105671007 endingPage "381" @default.
• W2105671007 startingPage "369" @default.
• W2105671007 abstract "The regulation of the 2-oxoglutarate dehydrogenase complex is central to intramitochondrial energy metabolism. In the present study, the active full-length E1 subunit of the human complex has been expressed and shown to be regulated by Ca2+, adenine nucleotides and NADH, with NADH exerting a major influence on the K0.5 value for Ca2+. We investigated two potential Ca2+-binding sites on E1, which we term site 1 (D114ADLD) and site 2 (E139SDLD). Comparison of sequences from vertebrates with those from Ca2+-insensitive non-vertebrate complexes suggest that site 1 may be the more important. Consistent with this view, a mutated form of E1, D114A, shows a 6-fold decrease in sensitivity for Ca2+, whereas variant ∆site1 (in which the sequence of site 1 is replaced by A114AALA) exhibits an almost complete loss of Ca2+ activation. Variant ∆site2 (in which the sequence is replaced with A139SALA) shows no measurable change in Ca2+ sensitivity. We conclude that site 1, but not site 2, forms part of a regulatory Ca2+-binding site, which is distinct from other previously described Ca2+-binding sites." @default.
• W2105671007 created "2016-06-24" @default.
• W2105671007 creator A5011164610 @default.
• W2105671007 creator A5045772980 @default.
• W2105671007 creator A5082178856 @default.
• W2105671007 date "2014-03-28" @default.
• W2105671007 modified "2023-10-03" @default.
• W2105671007 title "Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site" @default.
• W2105671007 cites W1560978813 @default.
• W2105671007 cites W1580746914 @default.
• W2105671007 cites W1581436439 @default.
• W2105671007 cites W1599096372 @default.
• W2105671007 cites W1599300439 @default.
• W2105671007 cites W1607256394 @default.
• W2105671007 cites W1756031092 @default.
• W2105671007 cites W181688216 @default.
• W2105671007 cites W1834004242 @default.
• W2105671007 cites W1935060748 @default.
• W2105671007 cites W1964005617 @default.
• W2105671007 cites W1967314244 @default.
• W2105671007 cites W1981526622 @default.
• W2105671007 cites W1986216188 @default.
• W2105671007 cites W1991216672 @default.
• W2105671007 cites W1999351218 @default.
• W2105671007 cites W2002357266 @default.
• W2105671007 cites W2005641666 @default.
• W2105671007 cites W2009301053 @default.
• W2105671007 cites W2012335235 @default.
• W2105671007 cites W2013070823 @default.
• W2105671007 cites W2016375009 @default.
• W2105671007 cites W2025032853 @default.
• W2105671007 cites W2038468721 @default.
• W2105671007 cites W2064795263 @default.
• W2105671007 cites W2067843162 @default.
• W2105671007 cites W2073706613 @default.
• W2105671007 cites W2084918846 @default.
• W2105671007 cites W2092340487 @default.
• W2105671007 cites W2099540110 @default.
• W2105671007 cites W2101840868 @default.
• W2105671007 cites W2110800533 @default.
• W2105671007 cites W2112473136 @default.
• W2105671007 cites W2125079066 @default.
• W2105671007 cites W2155596249 @default.
• W2105671007 cites W2158266834 @default.
• W2105671007 cites W2261313271 @default.
• W2105671007 cites W2319854114 @default.
• W2105671007 cites W236500271 @default.
• W2105671007 cites W2400196432 @default.
• W2105671007 cites W2428088027 @default.
• W2105671007 cites W2587935732 @default.
• W2105671007 cites W30877951 @default.
• W2105671007 cites W339155791 @default.
• W2105671007 cites W4320301318 @default.
• W2105671007 doi "https://doi.org/10.1042/bj20131664" @default.
• W2105671007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24495017" @default.
• W2105671007 hasPublicationYear "2014" @default.
• W2105671007 type Work @default.
• W2105671007 sameAs 2105671007 @default.
• W2105671007 citedByCount "34" @default.
• W2105671007 countsByYear W21056710072014 @default.
• W2105671007 countsByYear W21056710072016 @default.
• W2105671007 countsByYear W21056710072017 @default.
• W2105671007 countsByYear W21056710072018 @default.
• W2105671007 countsByYear W21056710072020 @default.
• W2105671007 countsByYear W21056710072021 @default.
• W2105671007 countsByYear W21056710072022 @default.
• W2105671007 countsByYear W21056710072023 @default.
• W2105671007 crossrefType "journal-article" @default.
• W2105671007 hasAuthorship W2105671007A5011164610 @default.
• W2105671007 hasAuthorship W2105671007A5045772980 @default.
• W2105671007 hasAuthorship W2105671007A5082178856 @default.
• W2105671007 hasConcept C104292427 @default.
• W2105671007 hasConcept C104317684 @default.
• W2105671007 hasConcept C107824862 @default.
• W2105671007 hasConcept C181199279 @default.
• W2105671007 hasConcept C2776319529 @default.
• W2105671007 hasConcept C41183919 @default.
• W2105671007 hasConcept C512185932 @default.
• W2105671007 hasConcept C55493867 @default.
• W2105671007 hasConcept C86803240 @default.
• W2105671007 hasConcept C96267730 @default.
• W2105671007 hasConceptScore W2105671007C104292427 @default.
• W2105671007 hasConceptScore W2105671007C104317684 @default.
• W2105671007 hasConceptScore W2105671007C107824862 @default.
• W2105671007 hasConceptScore W2105671007C181199279 @default.
• W2105671007 hasConceptScore W2105671007C2776319529 @default.
• W2105671007 hasConceptScore W2105671007C41183919 @default.
• W2105671007 hasConceptScore W2105671007C512185932 @default.
• W2105671007 hasConceptScore W2105671007C55493867 @default.
• W2105671007 hasConceptScore W2105671007C86803240 @default.
• W2105671007 hasConceptScore W2105671007C96267730 @default.
• W2105671007 hasIssue "2" @default.
• W2105671007 hasLocation W21056710071 @default.
• W2105671007 hasLocation W21056710072 @default.
• W2105671007 hasOpenAccess W2105671007 @default.
• W2105671007 hasPrimaryLocation W21056710071 @default.
• W2105671007 hasRelatedWork W1899901935 @default.
• W2105671007 hasRelatedWork W1975791793 @default.

• next