Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105680641> ?p ?o ?g. }
- W2105680641 abstract "Abstract Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the general biology and mechanism of γ-secretase and focus on the catalytic components – presenilins and their biological functions and contributions to the AD pathogenesis. The functions of presenilins are divided into γ-secretase dependent and γ-secretase independent ones. The γ-secretase dependent functions of presenilins are exemplified by the sequential cleavages in the processing of APP and Notch; the γ-secretase independent functions of presenilins include stabilizing β-catenin in Wnt signaling pathway, regulating calcium homeostasis and their interaction with synaptic transmission." @default.
- W2105680641 created "2016-06-24" @default.
- W2105680641 creator A5039728001 @default.
- W2105680641 creator A5069953764 @default.
- W2105680641 creator A5071165085 @default.
- W2105680641 creator A5078290472 @default.
- W2105680641 date "2013-07-17" @default.
- W2105680641 modified "2023-09-25" @default.
- W2105680641 title "Biological function of Presenilin and its role in AD pathogenesis" @default.
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