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• W2105689075 abstract "ABSTRACT The glycosyltransferase ElmGT from Streptomyces olivaceus is involved in the biosynthesis of the antitumor drug elloramycin, and it has been shown to possess a broad deoxysugar recognition pattern, being able to transfer different l - and d -deoxysugars to 8-demethyl-tetracenomycin C, the elloramycin aglycone. Site-directed mutagenesis in residues L309 and N312, located in the α/β/α motif within the nucleoside diphosphate-sugar binding region, can be used to modulate the substrate flexibility of ElmGT, making it more precise for transfer of specific deoxysugars." @default.
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• W2105689075 date "2009-04-15" @default.
• W2105689075 modified "2023-10-16" @default.
• W2105689075 title "Modulation of Deoxysugar Transfer by the Elloramycin Glycosyltransferase ElmGT through Site-Directed Mutagenesis" @default.
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• W2105689075 doi "https://doi.org/10.1128/jb.01747-08" @default.
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