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• W2105693312 startingPage "608" @default.
• W2105693312 abstract "We examine the hypotheses that the Streptomyces lividans potassium channel KcsA is gated at neutral pH by the electrochemical potential, and that its selectivity and conductance are governed at the cytoplasmic face by interactions between the KcsA polypeptides and a core molecule of inorganic polyphosphate (polyP). The four polypeptides of KcsA are postulated to surround the end unit of the polyP molecule with a collar of eight arginines, thereby modulating the negative charge of the polyP end unit and increasing its preference for binding monovalent cations. Here we show that KcsA channels can be activated in planar lipid bilayers at pH 7.4 by the chemical potential alone. Moreover, one or both of the C-terminal arginines are replaced with residues of progressively lower basicity–lysine, histidine, valine, asparagine–and the effects of these mutations on conductance and selectivity for K + over Mg 2+ is tested in planar bilayers as a function of Mg 2+ concentration and pH. As the basicity of the C-terminal residues decreases, Mg 2+ block increases, and Mg 2+ becomes permeant when medium pH is greater than the pI of the C-terminal residues. The results uphold the premise that polyP and the C-terminal arginines are decisive elements in KcsA channel regulation." @default.
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• W2105693312 date "2009-03-01" @default.
• W2105693312 modified "2023-09-24" @default.
• W2105693312 title "Role of polyphosphate in regulation of the Streptomyces lividans KcsA channel" @default.
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• W2105693312 doi "https://doi.org/10.1016/j.bbamem.2008.12.017" @default.
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