Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105718456> ?p ?o ?g. }
- W2105718456 endingPage "41625" @default.
- W2105718456 startingPage "41616" @default.
- W2105718456 abstract "N(ε)-Methylations of histone lysine residues play critical roles in cell biology by marking chromatin for transcriptional activation or repression. Lysine demethylases reverse N(ε)-methylation in a sequence- and methylation-selective manner. The determinants of sequence selectivity for histone demethylases have been unclear. The human JMJD2 (KDM4) H3K9 and H3K36 demethylases can be divided into members that act on both H3K9 and H3K36 and H3K9 alone. Kinetic, crystallographic, and mutagenetic studies in vitro and in cells on KDM4A-E reveal that selectivity is determined by multiple interactions within the catalytic domain but outside the active site. Structurally informed phylogenetic analyses reveal that KDM4A-C orthologues exist in all genome-sequenced vertebrates with earlier animals containing only a single KDM4 enzyme. KDM4D orthologues only exist in eutherians (placental mammals) where they are conserved, including proposed substrate sequence-determining residues. The results will be useful for the identification of inhibitors for specific histone demethylases." @default.
- W2105718456 created "2016-06-24" @default.
- W2105718456 creator A5000825987 @default.
- W2105718456 creator A5007099632 @default.
- W2105718456 creator A5030288845 @default.
- W2105718456 creator A5031142352 @default.
- W2105718456 creator A5039097729 @default.
- W2105718456 creator A5042398293 @default.
- W2105718456 creator A5064855716 @default.
- W2105718456 creator A5069487888 @default.
- W2105718456 creator A5072564424 @default.
- W2105718456 creator A5089017727 @default.
- W2105718456 date "2011-12-01" @default.
- W2105718456 modified "2023-10-15" @default.
- W2105718456 title "Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family" @default.
- W2105718456 cites W1520730837 @default.
- W2105718456 cites W1963909260 @default.
- W2105718456 cites W1968931043 @default.
- W2105718456 cites W1969233368 @default.
- W2105718456 cites W1978027379 @default.
- W2105718456 cites W1981259598 @default.
- W2105718456 cites W1981452104 @default.
- W2105718456 cites W1982409009 @default.
- W2105718456 cites W1988377666 @default.
- W2105718456 cites W1990949301 @default.
- W2105718456 cites W1992538495 @default.
- W2105718456 cites W1994286350 @default.
- W2105718456 cites W1995404170 @default.
- W2105718456 cites W2001401534 @default.
- W2105718456 cites W2001641653 @default.
- W2105718456 cites W2002676132 @default.
- W2105718456 cites W2020958679 @default.
- W2105718456 cites W2022702689 @default.
- W2105718456 cites W2023023321 @default.
- W2105718456 cites W2029865263 @default.
- W2105718456 cites W2030523067 @default.
- W2105718456 cites W2030692354 @default.
- W2105718456 cites W2035371038 @default.
- W2105718456 cites W2035526755 @default.
- W2105718456 cites W2038840577 @default.
- W2105718456 cites W2041406710 @default.
- W2105718456 cites W2044551569 @default.
- W2105718456 cites W2054643318 @default.
- W2105718456 cites W2059059097 @default.
- W2105718456 cites W2062113306 @default.
- W2105718456 cites W2062345287 @default.
- W2105718456 cites W2063756611 @default.
- W2105718456 cites W2063982921 @default.
- W2105718456 cites W2068157186 @default.
- W2105718456 cites W2073393692 @default.
- W2105718456 cites W2077981176 @default.
- W2105718456 cites W2089934626 @default.
- W2105718456 cites W2090805227 @default.
- W2105718456 cites W2094221767 @default.
- W2105718456 cites W2096083625 @default.
- W2105718456 cites W2097976632 @default.
- W2105718456 cites W2099667514 @default.
- W2105718456 cites W2102444784 @default.
- W2105718456 cites W2106921118 @default.
- W2105718456 cites W2111863839 @default.
- W2105718456 cites W2113945778 @default.
- W2105718456 cites W2120960764 @default.
- W2105718456 cites W2125765631 @default.
- W2105718456 cites W2127732469 @default.
- W2105718456 cites W2128778630 @default.
- W2105718456 cites W2130239280 @default.
- W2105718456 cites W2132614547 @default.
- W2105718456 cites W2134052811 @default.
- W2105718456 cites W2135422714 @default.
- W2105718456 cites W2136354440 @default.
- W2105718456 cites W2138992920 @default.
- W2105718456 cites W2144081223 @default.
- W2105718456 cites W2144275955 @default.
- W2105718456 cites W2144666643 @default.
- W2105718456 cites W2144878837 @default.
- W2105718456 cites W2160087459 @default.
- W2105718456 cites W2163325952 @default.
- W2105718456 cites W2171210849 @default.
- W2105718456 cites W2172060732 @default.
- W2105718456 cites W4212766227 @default.
- W2105718456 doi "https://doi.org/10.1074/jbc.m111.283689" @default.
- W2105718456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3308871" @default.
- W2105718456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21914792" @default.
- W2105718456 hasPublicationYear "2011" @default.
- W2105718456 type Work @default.
- W2105718456 sameAs 2105718456 @default.
- W2105718456 citedByCount "135" @default.
- W2105718456 countsByYear W21057184562012 @default.
- W2105718456 countsByYear W21057184562013 @default.
- W2105718456 countsByYear W21057184562014 @default.
- W2105718456 countsByYear W21057184562015 @default.
- W2105718456 countsByYear W21057184562016 @default.
- W2105718456 countsByYear W21057184562017 @default.
- W2105718456 countsByYear W21057184562018 @default.
- W2105718456 countsByYear W21057184562019 @default.
- W2105718456 countsByYear W21057184562020 @default.
- W2105718456 countsByYear W21057184562021 @default.
- W2105718456 countsByYear W21057184562022 @default.