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• W2105733786 abstract "Water plays a fundamental role in the folding, structure, dynamics, and function of proteins and peptides. The extracellular N-terminal domain of chemokine receptors is crucial in mediating binding affinity, receptor selectivity, and regulating function. The flexible N-terminal domain becomes ordered in membranes and membrane-mimetic assemblies, thereby indicating that the membrane could play an important role in regulating CXC chemokine receptor 1 (CXCR1) function. In view of the role of hydration in lipid–protein interactions in membranes, we explored the organization and dynamics of a 34-mer peptide of the CXCR1 N-terminal domain in reverse micelles by utilizing a combination of fluorescence-based approaches and circular dichroism spectroscopy. Our results show that the secondary structure adopted by the CXCR1 N-domain is critically dependent on hydration. The tryptophan residues of the CXCR1 N-domain experience motional restriction and exhibit red edge excitation shift (REES) upon incorporation in reverse micelles. REES and fluorescence lifetime exhibit reduction with increasing reverse micellar hydration. Time-resolved fluorescence anisotropy measurements reveal the effect of hydration on peptide rotational dynamics. Taken together, these results constitute the first report demonstrating modulation in the organization and dynamics of the N-terminal domain of a chemokine receptor in a membrane-like environment of varying hydration. We envisage that these results are relevant in the context of hydration in the function of G protein-coupled receptors." @default.
• W2105733786 created "2016-06-24" @default.
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• W2105733786 creator A5080366087 @default.
• W2105733786 date "2013-01-28" @default.
• W2105733786 modified "2023-09-27" @default.
• W2105733786 title "Organization and Dynamics of the N-Terminal Domain of Chemokine Receptor CXCR1 in Reverse Micelles: Effect of Graded Hydration" @default.
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• W2105733786 cites W1554512406 @default.
• W2105733786 cites W1608040 @default.
• W2105733786 cites W1624663212 @default.
• W2105733786 cites W1964111295 @default.
• W2105733786 cites W1966440976 @default.
• W2105733786 cites W1968136592 @default.
• W2105733786 cites W1970692516 @default.
• W2105733786 cites W1974292841 @default.
• W2105733786 cites W1975027476 @default.
• W2105733786 cites W1979103336 @default.
• W2105733786 cites W1979942024 @default.
• W2105733786 cites W1980469048 @default.
• W2105733786 cites W1985866183 @default.
• W2105733786 cites W1986156218 @default.
• W2105733786 cites W1989143126 @default.
• W2105733786 cites W1990569550 @default.
• W2105733786 cites W1990866743 @default.
• W2105733786 cites W1994415948 @default.
• W2105733786 cites W1995806978 @default.
• W2105733786 cites W1995820742 @default.
• W2105733786 cites W1997048904 @default.
• W2105733786 cites W1997105441 @default.
• W2105733786 cites W2001804099 @default.
• W2105733786 cites W2007760903 @default.
• W2105733786 cites W2010428573 @default.
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• W2105733786 cites W2018628462 @default.
• W2105733786 cites W2020087881 @default.
• W2105733786 cites W2025221665 @default.
• W2105733786 cites W2028712359 @default.
• W2105733786 cites W2035652358 @default.
• W2105733786 cites W2035723991 @default.
• W2105733786 cites W2036410568 @default.
• W2105733786 cites W2037460653 @default.
• W2105733786 cites W2044030515 @default.
• W2105733786 cites W2047131856 @default.
• W2105733786 cites W2049185216 @default.
• W2105733786 cites W2052498269 @default.
• W2105733786 cites W2053033209 @default.
• W2105733786 cites W2056630955 @default.
• W2105733786 cites W2057223279 @default.
• W2105733786 cites W2058663350 @default.
• W2105733786 cites W2061693144 @default.
• W2105733786 cites W2063408927 @default.
• W2105733786 cites W2072463712 @default.
• W2105733786 cites W2073161261 @default.
• W2105733786 cites W2078216776 @default.
• W2105733786 cites W2088459238 @default.
• W2105733786 cites W2090169937 @default.
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• W2105733786 cites W2122337510 @default.
• W2105733786 cites W2124615219 @default.
• W2105733786 cites W2126835369 @default.
• W2105733786 cites W2136822492 @default.
• W2105733786 cites W2150766477 @default.
• W2105733786 cites W2152853006 @default.
• W2105733786 cites W2156004732 @default.
• W2105733786 cites W2157087173 @default.
• W2105733786 cites W2157329817 @default.
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• W2105733786 doi "https://doi.org/10.1021/jp3095352" @default.
• W2105733786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3580202" @default.
• W2105733786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23311880" @default.
• W2105733786 hasPublicationYear "2013" @default.
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