FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105752803> ?p ?o ?g. }

• W2105752803 endingPage "527" @default.
• W2105752803 startingPage "501" @default.
• W2105752803 abstract "1. Spinal cord and hippocampal neurones in cell culture were voltage clamped using the tight-seal, whole-cell recording technique. The concentration of sodium and a series of divalent cations in the extracellular media was varied to study permeation through excitatory amino acid receptor channels activated by the selective agonists N-methyl-D-aspartic acid (NMDA), kainic acid and quisqualic acid. 2. On raising the extracellular calcium concentration, with [Na+]o held constant at 105 mM, the reversal potential of responses to NMDA shifted in the depolarizing direction. This shift was adequately described by the extended constant-field equation over the range 0.3-50 mM-calcium. Using ionic activity coefficients we calculate a value of PCa/PNa = 10.6. Under the same experimental conditions the reversal potential of responses to kainic and quisqualic acids was much less affected by raising the calcium concentration, such that PCa/PNa = 0.15. A depolarizing shift of the NMDA reversal potential was also recorded during application of 20 mM-barium, strontium or manganese, suggesting permeation of these ions. The permeability sequence was Ca2+ greater than Ba2+ greater than Sr2+ much greater than Mn2+. No depolarizing shift of the NMDA reversal potential occurred during application of 20 mM-cobalt, magnesium or nickel. 3. In experiments in which the extracellular Na+ concentration was varied the extended constant-field equation was adequate in predicting shifts of the NMDA reversal potential recorded on varying [Na+]o over the range 50-150 mM, but failed to accurately predict the reversal potential of responses to NMDA with 10 mM-[Ca2+]o and only 10 or 20 mM-[Na+]o. These results imply an apparent increase in PCa/PNa on lowering [Na+]o and may result from interaction of permeant ions within the channel. 4. Barium and to a lesser extent calcium, but not strontium (all 20 mM), reduced the slope conductance of responses to NMDA recorded within +/- 15 mV of the reversal potential; over this limited range of membrane potential the current-voltage relationship remained linear in the presence of each of these ions. In contrast manganese produced a strong, voltage-dependent block of responses to NMDA, similar to that produced by magnesium, such that even close to the reversal potential the NMDA current-voltage relationship was highly non-linear. Thus manganese both permeates and blocks the NMDA receptor channel. 5. Raising the extracellular calcium concentration, from 0.1 to 5 mM, had two effects on the conductance mechanism activated by NMDA.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2105752803 created "2016-06-24" @default.
• W2105752803 creator A5033661333 @default.
• W2105752803 creator A5042692406 @default.
• W2105752803 date "1987-12-01" @default.
• W2105752803 modified "2023-10-18" @default.
• W2105752803 title "Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones." @default.
• W2105752803 cites W139487551 @default.
• W2105752803 cites W1968333334 @default.
• W2105752803 cites W1971061189 @default.
• W2105752803 cites W1978675292 @default.
• W2105752803 cites W1982669777 @default.
• W2105752803 cites W1987636575 @default.
• W2105752803 cites W1990154764 @default.
• W2105752803 cites W1990323937 @default.
• W2105752803 cites W1991937796 @default.
• W2105752803 cites W1997511216 @default.
• W2105752803 cites W1997568797 @default.
• W2105752803 cites W1998347917 @default.
• W2105752803 cites W2005018000 @default.
• W2105752803 cites W2009667219 @default.
• W2105752803 cites W2010926499 @default.
• W2105752803 cites W2015252262 @default.
• W2105752803 cites W2015426350 @default.
• W2105752803 cites W2017424727 @default.
• W2105752803 cites W2019389360 @default.
• W2105752803 cites W2022576548 @default.
• W2105752803 cites W2027193377 @default.
• W2105752803 cites W2035026316 @default.
• W2105752803 cites W2037335023 @default.
• W2105752803 cites W2039753614 @default.
• W2105752803 cites W2042152248 @default.
• W2105752803 cites W2045925975 @default.
• W2105752803 cites W2055100632 @default.
• W2105752803 cites W2055385895 @default.
• W2105752803 cites W2056505626 @default.
• W2105752803 cites W2057315110 @default.
• W2105752803 cites W2059505091 @default.
• W2105752803 cites W2059519457 @default.
• W2105752803 cites W2069713657 @default.
• W2105752803 cites W2072176189 @default.
• W2105752803 cites W2080645324 @default.
• W2105752803 cites W2093510456 @default.
• W2105752803 cites W2094561033 @default.
• W2105752803 cites W2099061204 @default.
• W2105752803 cites W2110518868 @default.
• W2105752803 cites W2121436391 @default.
• W2105752803 cites W2121624942 @default.
• W2105752803 cites W2126814404 @default.
• W2105752803 cites W2126996448 @default.
• W2105752803 cites W2132665582 @default.
• W2105752803 cites W2133464980 @default.
• W2105752803 cites W2146152598 @default.
• W2105752803 cites W2148343974 @default.
• W2105752803 cites W2157926980 @default.
• W2105752803 cites W2159864873 @default.
• W2105752803 cites W2162206314 @default.
• W2105752803 cites W2169981344 @default.
• W2105752803 cites W2170271247 @default.
• W2105752803 cites W2471508020 @default.
• W2105752803 cites W47927869 @default.
• W2105752803 cites W87174765 @default.
• W2105752803 doi "https://doi.org/10.1113/jphysiol.1987.sp016883" @default.
• W2105752803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1191974" @default.
• W2105752803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2451020" @default.
• W2105752803 hasPublicationYear "1987" @default.
• W2105752803 type Work @default.
• W2105752803 sameAs 2105752803 @default.
• W2105752803 citedByCount "904" @default.
• W2105752803 countsByYear W21057528032012 @default.
• W2105752803 countsByYear W21057528032013 @default.
• W2105752803 countsByYear W21057528032014 @default.
• W2105752803 countsByYear W21057528032015 @default.
• W2105752803 countsByYear W21057528032016 @default.
• W2105752803 countsByYear W21057528032017 @default.
• W2105752803 countsByYear W21057528032018 @default.
• W2105752803 countsByYear W21057528032019 @default.
• W2105752803 countsByYear W21057528032020 @default.
• W2105752803 countsByYear W21057528032021 @default.
• W2105752803 countsByYear W21057528032022 @default.
• W2105752803 countsByYear W21057528032023 @default.
• W2105752803 crossrefType "journal-article" @default.
• W2105752803 hasAuthorship W2105752803A5033661333 @default.
• W2105752803 hasAuthorship W2105752803A5042692406 @default.
• W2105752803 hasBestOaLocation W21057528032 @default.
• W2105752803 hasConcept C12554922 @default.
• W2105752803 hasConcept C147944092 @default.
• W2105752803 hasConcept C160268369 @default.
• W2105752803 hasConcept C170493617 @default.
• W2105752803 hasConcept C178790620 @default.
• W2105752803 hasConcept C179104552 @default.
• W2105752803 hasConcept C185592680 @default.
• W2105752803 hasConcept C2776108384 @default.
• W2105752803 hasConcept C2776437795 @default.
• W2105752803 hasConcept C2778071365 @default.
• W2105752803 hasConcept C4141045 @default.
• W2105752803 hasConcept C519063684 @default.
• W2105752803 hasConcept C55493867 @default.

• next