Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105757811> ?p ?o ?g. }
- W2105757811 endingPage "12" @default.
- W2105757811 startingPage "12" @default.
- W2105757811 abstract "The TLR7/8 agonist 3M-052 and the TLR9 agonist CpG ODN both trigger innate immune responses that support the induction of tumor-specific immunity. Previous studies showed that these agonists used individually could improve the survival of mice challenged with small tumors but were of limited therapeutic benefit against large/advanced tumors.Normal mice were challenged with syngeneic tumors. Once these tumors reached clinically detectable size (500-800 mm(3)) they were treated by intra-tumoral injection with 3M-052 and/or CpG ODN. Anti-tumor immunity and tumor growth were evaluated.The co-delivery of agonists targeting TLRs 7, 8 and 9 increased the number and tumoricidal activity of tumor infiltrating CTL and NK cells while reducing the frequency of immunosuppressive MDSC. The combination of 3M-052 plus CpG ODN (but not each agent alone) eradicated large primary tumors and established long-term protective immunity.The combination of agonists targeting TLRs 7/8 and 9 represents a significant improvement in cancer immunotherapy." @default.
- W2105757811 created "2016-06-24" @default.
- W2105757811 creator A5003052953 @default.
- W2105757811 creator A5017576585 @default.
- W2105757811 creator A5020952032 @default.
- W2105757811 creator A5030604997 @default.
- W2105757811 creator A5043470455 @default.
- W2105757811 date "2014-01-01" @default.
- W2105757811 modified "2023-10-05" @default.
- W2105757811 title "Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors" @default.
- W2105757811 cites W1504879144 @default.
- W2105757811 cites W1512675081 @default.
- W2105757811 cites W1514540900 @default.
- W2105757811 cites W1524004374 @default.
- W2105757811 cites W1542775986 @default.
- W2105757811 cites W1550965773 @default.
- W2105757811 cites W1585754595 @default.
- W2105757811 cites W1829640917 @default.
- W2105757811 cites W1972776583 @default.
- W2105757811 cites W1977179270 @default.
- W2105757811 cites W1977957999 @default.
- W2105757811 cites W1984162437 @default.
- W2105757811 cites W1984618863 @default.
- W2105757811 cites W1990792892 @default.
- W2105757811 cites W1994391392 @default.
- W2105757811 cites W1995744610 @default.
- W2105757811 cites W1996641994 @default.
- W2105757811 cites W2000174284 @default.
- W2105757811 cites W2020914260 @default.
- W2105757811 cites W2022898219 @default.
- W2105757811 cites W2029208213 @default.
- W2105757811 cites W2033441782 @default.
- W2105757811 cites W2040074251 @default.
- W2105757811 cites W2047110135 @default.
- W2105757811 cites W2048073154 @default.
- W2105757811 cites W2054265941 @default.
- W2105757811 cites W2059884673 @default.
- W2105757811 cites W2060629187 @default.
- W2105757811 cites W2062530917 @default.
- W2105757811 cites W2067575233 @default.
- W2105757811 cites W2068515672 @default.
- W2105757811 cites W2075789186 @default.
- W2105757811 cites W2077508806 @default.
- W2105757811 cites W2080442727 @default.
- W2105757811 cites W2083349939 @default.
- W2105757811 cites W2084692958 @default.
- W2105757811 cites W2101831929 @default.
- W2105757811 cites W2103615468 @default.
- W2105757811 cites W2104266894 @default.
- W2105757811 cites W2110845079 @default.
- W2105757811 cites W2121044753 @default.
- W2105757811 cites W2123662098 @default.
- W2105757811 cites W2124904079 @default.
- W2105757811 cites W2124999867 @default.
- W2105757811 cites W2126397566 @default.
- W2105757811 cites W2129053095 @default.
- W2105757811 cites W2131419135 @default.
- W2105757811 cites W2131567916 @default.
- W2105757811 cites W2133449490 @default.
- W2105757811 cites W2145007235 @default.
- W2105757811 cites W2151777859 @default.
- W2105757811 cites W2160057355 @default.
- W2105757811 cites W2169035834 @default.
- W2105757811 cites W2169238760 @default.
- W2105757811 cites W2170123390 @default.
- W2105757811 cites W249403745 @default.
- W2105757811 cites W2046204077 @default.
- W2105757811 doi "https://doi.org/10.1186/2051-1426-2-12" @default.
- W2105757811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4075973" @default.
- W2105757811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24982761" @default.
- W2105757811 hasPublicationYear "2014" @default.
- W2105757811 type Work @default.
- W2105757811 sameAs 2105757811 @default.
- W2105757811 citedByCount "60" @default.
- W2105757811 countsByYear W21057578112014 @default.
- W2105757811 countsByYear W21057578112015 @default.
- W2105757811 countsByYear W21057578112016 @default.
- W2105757811 countsByYear W21057578112017 @default.
- W2105757811 countsByYear W21057578112018 @default.
- W2105757811 countsByYear W21057578112019 @default.
- W2105757811 countsByYear W21057578112020 @default.
- W2105757811 countsByYear W21057578112021 @default.
- W2105757811 countsByYear W21057578112022 @default.
- W2105757811 countsByYear W21057578112023 @default.
- W2105757811 crossrefType "journal-article" @default.
- W2105757811 hasAuthorship W2105757811A5003052953 @default.
- W2105757811 hasAuthorship W2105757811A5017576585 @default.
- W2105757811 hasAuthorship W2105757811A5020952032 @default.
- W2105757811 hasAuthorship W2105757811A5030604997 @default.
- W2105757811 hasAuthorship W2105757811A5043470455 @default.
- W2105757811 hasBestOaLocation W21057578111 @default.
- W2105757811 hasConcept C104317684 @default.
- W2105757811 hasConcept C126322002 @default.
- W2105757811 hasConcept C136449434 @default.
- W2105757811 hasConcept C147969180 @default.
- W2105757811 hasConcept C150194340 @default.
- W2105757811 hasConcept C167672396 @default.
- W2105757811 hasConcept C170493617 @default.