FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105758533> ?p ?o ?g. }

• W2105758533 endingPage "88" @default.
• W2105758533 startingPage "79" @default.
• W2105758533 abstract "To probe the role of human plasma fibronectin in modulating human blood-derived macrophage adhesion and fusion to form multinucleated foreign-body giant cells (FBGC), a series of biomimetic oligopeptides based on the functional structure of fibronectin was designed and synthesized. Peptides incorporated the RGD and PHSRN integrin-binding sequences from FIII-10 and FIII-9 modules, respectively, and the PRRARV sequence from the C-terminal heparin-binding domain, either alone or in combination. Peptides were immobilized onto a polyethyleneglycol-based polymer substrate. The following conclusions were reached. Fibronectin modulated macrophage adhesion and the extent (i.e., size) of FBGC formation on control surfaces in the presence of serum proteins. Macrophages adhered to all substrates with relatively subtle differences between adhesion mediated by RGD, PHSRN, PRRARV, or combinations thereof. beta1-integrin subunit was essential in macrophage adhesion to peptide-grafted networks in a receptor-peptide specific manner, whereas beta3-integrin subunit was less important. Macrophage adhesion to PRRARV was mediated primarily by the direct interaction with integrins. RGD or PHSRN alone did not provide an adequate substrate for macrophage fusion to form FBGCs. However, the PHSRN synergistic site and the RGD site in a single oligopeptide provided a substrate for FBGC formation that was statistically comparable to that on the positive control material in the presence of serum proteins. This response was highly dependent upon the relative orientation between RGD and PHSRN. PRRARV did not support FBGC formation. These results demonstrate the importance of fibronectin and, specifically, the synergy between RGD and PHSRN domains, in supporting macrophage fusion to form FBGCs." @default.
• W2105758533 created "2016-06-24" @default.
• W2105758533 creator A5031517705 @default.
• W2105758533 creator A5078697022 @default.
• W2105758533 creator A5079819848 @default.
• W2105758533 creator A5086230562 @default.
• W2105758533 date "2001-01-01" @default.
• W2105758533 modified "2023-10-10" @default.
• W2105758533 title "Fibronectin modulates macrophage adhesion and FBGC formation: The role of RGD, PHSRN, and PRRARV domains" @default.
• W2105758533 cites W1504989678 @default.
• W2105758533 cites W1577729093 @default.
• W2105758533 cites W1972278871 @default.
• W2105758533 cites W1975427965 @default.
• W2105758533 cites W1976230888 @default.
• W2105758533 cites W1980698764 @default.
• W2105758533 cites W1985960454 @default.
• W2105758533 cites W1990998602 @default.
• W2105758533 cites W2001323028 @default.
• W2105758533 cites W2024256121 @default.
• W2105758533 cites W2024373128 @default.
• W2105758533 cites W2024895368 @default.
• W2105758533 cites W2032478134 @default.
• W2105758533 cites W2037455416 @default.
• W2105758533 cites W2045491514 @default.
• W2105758533 cites W2049868653 @default.
• W2105758533 cites W2053919896 @default.
• W2105758533 cites W2059695583 @default.
• W2105758533 cites W2061609938 @default.
• W2105758533 cites W2068640368 @default.
• W2105758533 cites W2078057379 @default.
• W2105758533 cites W2088682530 @default.
• W2105758533 cites W2092730327 @default.
• W2105758533 cites W2096133301 @default.
• W2105758533 cites W2114286636 @default.
• W2105758533 cites W2133647529 @default.
• W2105758533 cites W2147791888 @default.
• W2105758533 cites W2150312527 @default.
• W2105758533 cites W2154214219 @default.
• W2105758533 cites W2160726577 @default.
• W2105758533 cites W2163058312 @default.
• W2105758533 cites W2252694627 @default.
• W2105758533 cites W2286026684 @default.
• W2105758533 cites W2468601152 @default.
• W2105758533 cites W4240037437 @default.
• W2105758533 doi "https://doi.org/10.1002/1097-4636(200104)55:1<79::aid-jbm110>3.0.co;2-z" @default.
• W2105758533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11426401" @default.
• W2105758533 hasPublicationYear "2001" @default.
• W2105758533 type Work @default.
• W2105758533 sameAs 2105758533 @default.
• W2105758533 citedByCount "128" @default.
• W2105758533 countsByYear W21057585332012 @default.
• W2105758533 countsByYear W21057585332013 @default.
• W2105758533 countsByYear W21057585332014 @default.
• W2105758533 countsByYear W21057585332015 @default.
• W2105758533 countsByYear W21057585332016 @default.
• W2105758533 countsByYear W21057585332017 @default.
• W2105758533 countsByYear W21057585332018 @default.
• W2105758533 countsByYear W21057585332019 @default.
• W2105758533 countsByYear W21057585332020 @default.
• W2105758533 countsByYear W21057585332021 @default.
• W2105758533 countsByYear W21057585332022 @default.
• W2105758533 crossrefType "journal-article" @default.
• W2105758533 hasAuthorship W2105758533A5031517705 @default.
• W2105758533 hasAuthorship W2105758533A5078697022 @default.
• W2105758533 hasAuthorship W2105758533A5079819848 @default.
• W2105758533 hasAuthorship W2105758533A5086230562 @default.
• W2105758533 hasConcept C108657112 @default.
• W2105758533 hasConcept C12554922 @default.
• W2105758533 hasConcept C13935069 @default.
• W2105758533 hasConcept C142724271 @default.
• W2105758533 hasConcept C159985019 @default.
• W2105758533 hasConcept C170493617 @default.
• W2105758533 hasConcept C185592680 @default.
• W2105758533 hasConcept C189165786 @default.
• W2105758533 hasConcept C192562407 @default.
• W2105758533 hasConcept C195687474 @default.
• W2105758533 hasConcept C202751555 @default.
• W2105758533 hasConcept C2779244956 @default.
• W2105758533 hasConcept C2779281246 @default.
• W2105758533 hasConcept C55493867 @default.
• W2105758533 hasConcept C71924100 @default.
• W2105758533 hasConcept C84416704 @default.
• W2105758533 hasConcept C85789140 @default.
• W2105758533 hasConcept C86492073 @default.
• W2105758533 hasConcept C86803240 @default.
• W2105758533 hasConcept C95444343 @default.
• W2105758533 hasConceptScore W2105758533C108657112 @default.
• W2105758533 hasConceptScore W2105758533C12554922 @default.
• W2105758533 hasConceptScore W2105758533C13935069 @default.
• W2105758533 hasConceptScore W2105758533C142724271 @default.
• W2105758533 hasConceptScore W2105758533C159985019 @default.
• W2105758533 hasConceptScore W2105758533C170493617 @default.
• W2105758533 hasConceptScore W2105758533C185592680 @default.
• W2105758533 hasConceptScore W2105758533C189165786 @default.
• W2105758533 hasConceptScore W2105758533C192562407 @default.
• W2105758533 hasConceptScore W2105758533C195687474 @default.
• W2105758533 hasConceptScore W2105758533C202751555 @default.
• W2105758533 hasConceptScore W2105758533C2779244956 @default.

• next