FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105762010> ?p ?o ?g. }

• W2105762010 endingPage "872" @default.
• W2105762010 startingPage "862" @default.
• W2105762010 abstract "Cellular Src (c-Src) integrates a large number of signal transduction pathways regulating cell division, migration, and other aspects of cell physiology. Mutations of Src kinase have not been described in human prostate cancer, but evidence for increased levels of expression accompanying cancer progression has been reported. We analyzed overexpression of c-Src in naïve mouse prostate epithelium and observed no change in tubule formation frequency or histologic structure. However, when enhanced c-Src expression is coupled with enhanced expression of androgen receptor (AR), it results in a strong activation of Src kinase activity accompanied by activation of the MAPK pathway, and enhanced AR activity. Similar to the pathology induced by constitutively active c-Src(Y529F), the tubules progress to frank carcinoma with invasion and display markers of epithelial-to-mesenchymal transition. These combined results suggest that nonmutated Src kinase may play a more important role in the genesis and progression of prostate cancer than previously appreciated and that epigenetic changes that enhance the level of AR may select for enhanced expression of c-Src with accompanying activation and a strong drive to malignant progression." @default.
• W2105762010 created "2016-06-24" @default.
• W2105762010 creator A5013861698 @default.
• W2105762010 creator A5029912396 @default.
• W2105762010 creator A5043368519 @default.
• W2105762010 creator A5086573133 @default.
• W2105762010 creator A5087708211 @default.
• W2105762010 date "2011-02-01" @default.
• W2105762010 modified "2023-10-07" @default.
• W2105762010 title "Invasive Prostate Carcinoma Driven by c-Src and Androgen Receptor Synergy" @default.
• W2105762010 cites W1594706458 @default.
• W2105762010 cites W1963749564 @default.
• W2105762010 cites W1964081206 @default.
• W2105762010 cites W1965734230 @default.
• W2105762010 cites W1967826862 @default.
• W2105762010 cites W1983225862 @default.
• W2105762010 cites W1989214629 @default.
• W2105762010 cites W1994470823 @default.
• W2105762010 cites W1996118868 @default.
• W2105762010 cites W2005528673 @default.
• W2105762010 cites W2011566841 @default.
• W2105762010 cites W2014952307 @default.
• W2105762010 cites W2017209924 @default.
• W2105762010 cites W2019602163 @default.
• W2105762010 cites W2036988959 @default.
• W2105762010 cites W2046234516 @default.
• W2105762010 cites W2046679772 @default.
• W2105762010 cites W2055853153 @default.
• W2105762010 cites W2056676856 @default.
• W2105762010 cites W2058596530 @default.
• W2105762010 cites W2069180517 @default.
• W2105762010 cites W2077431712 @default.
• W2105762010 cites W2078400569 @default.
• W2105762010 cites W2080761866 @default.
• W2105762010 cites W2081777956 @default.
• W2105762010 cites W2082055110 @default.
• W2105762010 cites W2084715195 @default.
• W2105762010 cites W2088179569 @default.
• W2105762010 cites W2101954532 @default.
• W2105762010 cites W2117996979 @default.
• W2105762010 cites W2118436380 @default.
• W2105762010 cites W2125752165 @default.
• W2105762010 cites W2126015832 @default.
• W2105762010 cites W2128791083 @default.
• W2105762010 cites W2129781547 @default.
• W2105762010 cites W2134965738 @default.
• W2105762010 cites W2138067522 @default.
• W2105762010 cites W2139695668 @default.
• W2105762010 cites W2140551998 @default.
• W2105762010 cites W2141255350 @default.
• W2105762010 cites W2142284564 @default.
• W2105762010 cites W2143060756 @default.
• W2105762010 cites W2144509773 @default.
• W2105762010 cites W2166368669 @default.
• W2105762010 cites W2168011358 @default.
• W2105762010 doi "https://doi.org/10.1158/0008-5472.can-10-1605" @default.
• W2105762010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3032821" @default.
• W2105762010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21135112" @default.
• W2105762010 hasPublicationYear "2011" @default.
• W2105762010 type Work @default.
• W2105762010 sameAs 2105762010 @default.
• W2105762010 citedByCount "81" @default.
• W2105762010 countsByYear W21057620102012 @default.
• W2105762010 countsByYear W21057620102013 @default.
• W2105762010 countsByYear W21057620102014 @default.
• W2105762010 countsByYear W21057620102015 @default.
• W2105762010 countsByYear W21057620102016 @default.
• W2105762010 countsByYear W21057620102017 @default.
• W2105762010 countsByYear W21057620102018 @default.
• W2105762010 countsByYear W21057620102019 @default.
• W2105762010 countsByYear W21057620102020 @default.
• W2105762010 countsByYear W21057620102021 @default.
• W2105762010 countsByYear W21057620102022 @default.
• W2105762010 countsByYear W21057620102023 @default.
• W2105762010 crossrefType "journal-article" @default.
• W2105762010 hasAuthorship W2105762010A5013861698 @default.
• W2105762010 hasAuthorship W2105762010A5029912396 @default.
• W2105762010 hasAuthorship W2105762010A5043368519 @default.
• W2105762010 hasAuthorship W2105762010A5086573133 @default.
• W2105762010 hasAuthorship W2105762010A5087708211 @default.
• W2105762010 hasBestOaLocation W21057620101 @default.
• W2105762010 hasConcept C108636557 @default.
• W2105762010 hasConcept C121608353 @default.
• W2105762010 hasConcept C126322002 @default.
• W2105762010 hasConcept C184235292 @default.
• W2105762010 hasConcept C2776235491 @default.
• W2105762010 hasConcept C2777546739 @default.
• W2105762010 hasConcept C2779256057 @default.
• W2105762010 hasConcept C2780192828 @default.
• W2105762010 hasConcept C502942594 @default.
• W2105762010 hasConcept C61367390 @default.
• W2105762010 hasConcept C62478195 @default.
• W2105762010 hasConcept C71924100 @default.
• W2105762010 hasConcept C86803240 @default.
• W2105762010 hasConcept C95444343 @default.
• W2105762010 hasConceptScore W2105762010C108636557 @default.
• W2105762010 hasConceptScore W2105762010C121608353 @default.
• W2105762010 hasConceptScore W2105762010C126322002 @default.

• next