FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105772180> ?p ?o ?g. }

• W2105772180 endingPage "508" @default.
• W2105772180 startingPage "499" @default.
• W2105772180 abstract "Background: It is well known that long-term morphine administration results in tolerance, which limits the clinical use of this drug in pain management. Methods: Male Wistar rats were randomly assigned to receive one of four different infusions: morphine [15 μg/h, intrathecal (i.t.)], saline, MK-801 (5 μg/h, i.t.) plus morphine (15 μg/h, i.t.), or MK-801 (5 μg/h, i.t.) alone. Results: Morphine infusion induced a maximal antinociceptive effect on day 1 and tolerance on day 3, and the maximal anti-receptive tolerance was observed on day 5. Co-infusing MK-801 with morphine attenuated morphine's anti-receptive tolerance. Two-dimensional gel electrophoretic analysis of spinal proteins revealed that eight protein spots were up-regulated in morphine-tolerant rats, and that they were significantly inhibited by MK-801 co-infusion. Among the up-regulated proteins, glial fibrillary acid protein (GFAP), a glial-specific maker, was identified by mass spectrometry. This finding was also confirmed by Western blot analysis. Conclusion: Using proteomic analysis, we identified eight GFAP protein spots that were up-regulated in the dorsal horn of morphine-tolerant rat spinal cords. This up-regulation was partly inhibited by N-methyl-d-aspartate receptor antagonist MK-801 co-infusion, which suggests that GFAP protein can be considered to be a pathogenesis marker of morphine tolerance." @default.
• W2105772180 created "2016-06-24" @default.
• W2105772180 creator A5008726879 @default.
• W2105772180 creator A5017729534 @default.
• W2105772180 creator A5018301512 @default.
• W2105772180 creator A5046169921 @default.
• W2105772180 creator A5053645631 @default.
• W2105772180 creator A5063096009 @default.
• W2105772180 creator A5073309972 @default.
• W2105772180 creator A5089065789 @default.
• W2105772180 date "2008-03-13" @default.
• W2105772180 modified "2023-09-25" @default.
• W2105772180 title "<i>N</i>-Methyl-<scp>d</scp>-aspartate receptor antagonist MK-801 attenuates morphine tolerance and associated glial fibrillary acid protein up-regulation: a proteomic approach" @default.
• W2105772180 cites W1512847484 @default.
• W2105772180 cites W1775749144 @default.
• W2105772180 cites W1968402792 @default.
• W2105772180 cites W1969262598 @default.
• W2105772180 cites W1971063834 @default.
• W2105772180 cites W1972467982 @default.
• W2105772180 cites W1976219259 @default.
• W2105772180 cites W1979498042 @default.
• W2105772180 cites W1984252894 @default.
• W2105772180 cites W1987783006 @default.
• W2105772180 cites W1988184119 @default.
• W2105772180 cites W2007659050 @default.
• W2105772180 cites W2014089147 @default.
• W2105772180 cites W2033525233 @default.
• W2105772180 cites W2040725197 @default.
• W2105772180 cites W2051113383 @default.
• W2105772180 cites W2052748706 @default.
• W2105772180 cites W2055390759 @default.
• W2105772180 cites W2068663798 @default.
• W2105772180 cites W2071488336 @default.
• W2105772180 cites W2075807595 @default.
• W2105772180 cites W2078788974 @default.
• W2105772180 cites W2088163920 @default.
• W2105772180 cites W2093836826 @default.
• W2105772180 cites W2096602531 @default.
• W2105772180 cites W2110945744 @default.
• W2105772180 cites W2116903459 @default.
• W2105772180 cites W224499986 @default.
• W2105772180 doi "https://doi.org/10.1111/j.1399-6576.2008.01605.x" @default.
• W2105772180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18339156" @default.
• W2105772180 hasPublicationYear "2008" @default.
• W2105772180 type Work @default.
• W2105772180 sameAs 2105772180 @default.
• W2105772180 citedByCount "16" @default.
• W2105772180 countsByYear W21057721802012 @default.
• W2105772180 countsByYear W21057721802014 @default.
• W2105772180 countsByYear W21057721802016 @default.
• W2105772180 countsByYear W21057721802017 @default.
• W2105772180 countsByYear W21057721802018 @default.
• W2105772180 countsByYear W21057721802021 @default.
• W2105772180 countsByYear W21057721802022 @default.
• W2105772180 crossrefType "journal-article" @default.
• W2105772180 hasAuthorship W2105772180A5008726879 @default.
• W2105772180 hasAuthorship W2105772180A5017729534 @default.
• W2105772180 hasAuthorship W2105772180A5018301512 @default.
• W2105772180 hasAuthorship W2105772180A5046169921 @default.
• W2105772180 hasAuthorship W2105772180A5053645631 @default.
• W2105772180 hasAuthorship W2105772180A5063096009 @default.
• W2105772180 hasAuthorship W2105772180A5073309972 @default.
• W2105772180 hasAuthorship W2105772180A5089065789 @default.
• W2105772180 hasConcept C104317684 @default.
• W2105772180 hasConcept C126322002 @default.
• W2105772180 hasConcept C134018914 @default.
• W2105772180 hasConcept C15490471 @default.
• W2105772180 hasConcept C170493617 @default.
• W2105772180 hasConcept C185592680 @default.
• W2105772180 hasConcept C204232928 @default.
• W2105772180 hasConcept C2776415932 @default.
• W2105772180 hasConcept C2776885963 @default.
• W2105772180 hasConcept C2777389121 @default.
• W2105772180 hasConcept C2777836312 @default.
• W2105772180 hasConcept C2780495277 @default.
• W2105772180 hasConcept C55493867 @default.
• W2105772180 hasConcept C67018056 @default.
• W2105772180 hasConcept C71924100 @default.
• W2105772180 hasConcept C98274493 @default.
• W2105772180 hasConceptScore W2105772180C104317684 @default.
• W2105772180 hasConceptScore W2105772180C126322002 @default.
• W2105772180 hasConceptScore W2105772180C134018914 @default.
• W2105772180 hasConceptScore W2105772180C15490471 @default.
• W2105772180 hasConceptScore W2105772180C170493617 @default.
• W2105772180 hasConceptScore W2105772180C185592680 @default.
• W2105772180 hasConceptScore W2105772180C204232928 @default.
• W2105772180 hasConceptScore W2105772180C2776415932 @default.
• W2105772180 hasConceptScore W2105772180C2776885963 @default.
• W2105772180 hasConceptScore W2105772180C2777389121 @default.
• W2105772180 hasConceptScore W2105772180C2777836312 @default.
• W2105772180 hasConceptScore W2105772180C2780495277 @default.
• W2105772180 hasConceptScore W2105772180C55493867 @default.
• W2105772180 hasConceptScore W2105772180C67018056 @default.
• W2105772180 hasConceptScore W2105772180C71924100 @default.
• W2105772180 hasConceptScore W2105772180C98274493 @default.
• W2105772180 hasIssue "4" @default.
• W2105772180 hasLocation W21057721801 @default.
• W2105772180 hasLocation W21057721802 @default.

• next