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• W2105777551 abstract "Abstract. . 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase and HMG-CoA reductase show coordinated regulation in the fat body of Blattella germanica females. Since the profile of activity is parallel to the cycle of vitellogenin production, we postulated a link between the mevalonate pathway and vitellogenesis. Here we have studied both enzymes in females of B.germanica modified by ovariectomy (which leads to a saturable accumulation of vitellogenin) and allatectomy (which supresses vitellogenesis). Protein levels and enzymatic activity for both enzymes in ovariectomized specimens rose early in the first days of imaginal life and remained high until the end of the period studied, whereas controls showed cyclic profiles. In allatectomized specimens the same parameters were measured on day 4 of adult life and values were much lower with respect to controls. The parallelism between the patterns of HMG-CoA synthase and reductase, and that of vitellogenin, suggests a functional relationship between the mevalonate pathway and the glycosylation of vitellogenin through dolichol intermediates." @default.
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• W2105777551 date "1997-03-01" @default.
• W2105777551 modified "2023-10-16" @default.
• W2105777551 title "Expression and activity of 3-hydroxy-3-methylglutaryl-CoA synthase and reductase in the fat body of ovariectomized and allatectomized Blattella germanica" @default.
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• W2105777551 doi "https://doi.org/10.1111/j.1365-3032.1997.tb01134.x" @default.
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