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- W2105779929 abstract "Summary This study was designed to determine the possible asssociation between selected FAS and FASLG polymorphisms and Hepatitis B virus ( HBV ) infection. FAS ‐670 G/A, FAS ‐1377 G/A, FASLG ‐844 T/C and FASLG IVS 2nt‐124 A/G polymorphisms were genotyped by polymerase chain reaction and restriction fragment length polymorphism ( PCR ‐ RFLP ). A total of age and sex matched 108 controls and a hundred chronic HBV patients were recruited to conduct a case–control study. FAS ‐670 polymorphism was associated with chronic HBV infection ( P = 0.03) FAS ‐ 1377 GG , GA and AA genotypes among the cases (90%, 5% and 5%, respectively) were significantly different from those among the controls (68%, 31.5% and 5.6%; P = 0.00). FASLG ‐844 allele distribution was similar between the groups ( P = 0.17) but TC genotype (67.3%) was frequent in chronic HBV patients, while CC genotype was found significantly higher (29.6%) in controls. No association between FASLG IVS 2nt‐124 polymorphism and chronic HBV infection could be identified ( P = 0.55). FAS ‐670 polymorphism is associated with chronic HBV infection, while FASLG IVS 2nt‐124 A/G polymorphism is not. The FAS ‐1377G/A and FASLG ‐ 844 T/C genotypes are likely to play a substantial role in HBV infection. Further studies evaluating polymorphisms in other genes related with apoptosis are needed to elucidate the role of genetic variation in HBV infection." @default.
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- W2105779929 date "2013-04-07" @default.
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- W2105779929 title "Evaluation of death pathway genes<i>FAS</i>and<i>FASL</i>polymorphisms in chronic HBV infection" @default.
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- W2105779929 doi "https://doi.org/10.1111/iji.12056" @default.
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